Outputs (2149)

Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers (2024)
Journal Article
Diaz, F., Zimmermann, L., Dale, T. P., Forsyth, N. R., & Boccaccini, A. R. (2024). Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers. Carbohydrate Polymer Technologies and Applications, 7, Article 100447. https://doi.org/10.1016/j.carpta.2024.100447

Rotator cuff injuries affect a large percentage of the population worldwide. Surgical repair has rates of failure of up to 70%, and existing materials used in the reinforcement of injuries often lack appropriate mechanical properties and biodegradabi... Read More about Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers.

Multiparametric Modulation of Magnetic Transduction for Biomolecular Sensing in Liquids (2024)
Journal Article
Sanz-de Diego, E., Aires, A., Palacios Alonso, P., Cabrera, D., Silvestri, N., Artés-Ibañez, E. J., …Teran, F. J. J. (2024). Multiparametric Modulation of Magnetic Transduction for Biomolecular Sensing in Liquids. Nanoscale, 16(8), 4082-4094. https://doi.org/10.1039/d3nr06489a

The recent COVID19 pandemic has remarkably boosted the research on in vitro diagnosis assays to detect biomarkers in biological fluids. Specificity and sensitivity are mandatory for diagnostic kits aiming to reach clinical stages. Whilst the modulati... Read More about Multiparametric Modulation of Magnetic Transduction for Biomolecular Sensing in Liquids.

New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling (2024)
Journal Article
Salomatina, O. V., Kornienko, T. E., Zakharenko, A. L., Komarova, N. I., Achara, C., Reynisson, J., …Volcho, K. P. (in press). New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling. Molecules, 29(3), Article 581. https://doi.org/10.3390/molecules29030581

Deoxycholic acid derivatives containing various heterocyclic functional groups at C-3 on the steroid scaffold were designed and synthesized as promising dual tyrosyl-DNA phosphodiesterase 1 and 2 (TDP1 and TDP2) inhibitors, which are potential target... Read More about New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling.

Anterior cruciate ligament reconstruction in skeletally immature patients is effective: A systematic review (2024)
Journal Article
Migliorini, F., Cocconi, F., Schäfer, L., Memminger, M. K., Giorgino, R., & Maffulli, N. (in press). Anterior cruciate ligament reconstruction in skeletally immature patients is effective: A systematic review. Knee Surgery, Sports Traumatology, Arthroscopy, 32(2), 418-431. https://doi.org/10.1002/ksa.12048

Purpose The present study evaluated the outcomes of anterior cruciate ligament (ACL) reconstruction in children with open physes. The outcomes of interest were to compare the increase in joint laxity and PROMs from baseline to the last follow-up, th... Read More about Anterior cruciate ligament reconstruction in skeletally immature patients is effective: A systematic review.

TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity (2024)
Journal Article
Dogan, F., & Forsyth, N. R. (in press). TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity. Biomolecules, 14(1), Article 131. https://doi.org/10.3390/biom14010131

Telomere repeats protect linear chromosomes from degradation, and telomerase has a prominent role in their maintenance. Telomerase has telomere-independent effects on cell proliferation, DNA replication, differentiation, and tumorigenesis. TERT (telo... Read More about TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity.

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., …Holden, M. A. (in press). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1 (2024)
Journal Article
Munkuev, A. A., Zakharenko, A. L., Kornienko, T. E., Dyrkheeva, N. S., Ilina, E. S., Suslov, E. V., …Lavrik, O. I. (2024). Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1. Medicinal Chemistry Research, 33(2), 324-335. https://doi.org/10.1007/s00044-023-03184-x

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a DNA repair enzyme that can reduce the efficacy of some anticancer drugs targeting topoisomerase 1 (TOP1) making it a promising target for antitumor therapy when combined with TOP1 poisons. Here we describe... Read More about Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1.

Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review (2024)
Journal Article
Migliorini, F., Maffulli, N., Schäfer, L., Simeone, F., Bell, A., & Hofmann, U. K. (in press). Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review. Knee Surgery & Related Research, 36(1), Article 3. https://doi.org/10.1186/s43019-024-00210-z

Background The present systematic review investigated the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) of several frequent and established PROMs used to assess patien... Read More about Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review.

Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis (2024)
Journal Article
Migliorini, F., Maffulli, N., Velaj, E., Bell, A., Kämmer, D., Hildebrand, F., …Eschweiler, J. (in press). Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis. Journal of Orthopaedics and Traumatology, 25(1), 1. https://doi.org/10.1186/s10195-023-00742-2

Background: Several clinical investigations have compared different pharmacologic agents for the prophylaxis of venous thromboembolism (VTE). However, no consensus has been reached. The present investigation compared enoxaparin, fondaparinux, aspirin... Read More about Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis.

A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION (2024)
Conference Proceeding
Clerici, M., Ciardulli, M., Forsyth, N., Maffulli, N., & Della Porta, G. (2024). A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION. . https://doi.org/10.1302/1358-992x.2024.2.013

Tendon injuries are a common problem that can significantly impact an individual's quality of life. While traditional surgical methods have been used to address this issue, Extracellular Vesicles (EVs) have emerged as a promising approach to promote... Read More about A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION.