Outputs (2157)

Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1 (2024)
Journal Article
Munkuev, A. A., Zakharenko, A. L., Kornienko, T. E., Dyrkheeva, N. S., Ilina, E. S., Suslov, E. V., …Lavrik, O. I. (2024). Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1. Medicinal Chemistry Research, 33(2), 324-335. https://doi.org/10.1007/s00044-023-03184-x

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a DNA repair enzyme that can reduce the efficacy of some anticancer drugs targeting topoisomerase 1 (TOP1) making it a promising target for antitumor therapy when combined with TOP1 poisons. Here we describe... Read More about Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1.

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., …Holden, M. A. (in press). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review (2024)
Journal Article
Migliorini, F., Maffulli, N., Schäfer, L., Simeone, F., Bell, A., & Hofmann, U. K. (in press). Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review. Knee Surgery & Related Research, 36(1), Article 3. https://doi.org/10.1186/s43019-024-00210-z

Background The present systematic review investigated the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) of several frequent and established PROMs used to assess patien... Read More about Minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient-acceptable symptom state (PASS) in patients who have undergone total knee arthroplasty: a systematic review.

Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis (2024)
Journal Article
Migliorini, F., Maffulli, N., Velaj, E., Bell, A., Kämmer, D., Hildebrand, F., …Eschweiler, J. (in press). Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis. Journal of Orthopaedics and Traumatology, 25(1), 1. https://doi.org/10.1186/s10195-023-00742-2

Background: Several clinical investigations have compared different pharmacologic agents for the prophylaxis of venous thromboembolism (VTE). However, no consensus has been reached. The present investigation compared enoxaparin, fondaparinux, aspirin... Read More about Antithrombotic prophylaxis following total hip arthroplasty: a level I Bayesian network meta-analysis.

A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION (2024)
Conference Proceeding
Clerici, M., Ciardulli, M., Forsyth, N., Maffulli, N., & Della Porta, G. (2024). A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION. . https://doi.org/10.1302/1358-992x.2024.2.013

Tendon injuries are a common problem that can significantly impact an individual's quality of life. While traditional surgical methods have been used to address this issue, Extracellular Vesicles (EVs) have emerged as a promising approach to promote... Read More about A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION.

785 Co-contextualising and Implementing evidence-based care model for osteoarthritis: Nigerian case study in the Joint Implementation of Guidelines for OSteoArthritis in West-Africa (JIGSAW-A) (2024)
Presentation / Conference
Babatunde, O. O., Adetunji, O. A., Alonge, I., Owoyemi, T., Taiwo, P., Ogunbanjo, A., …Mallen, C. (2024, January). 785 Co-contextualising and Implementing evidence-based care model for osteoarthritis: Nigerian case study in the Joint Implementation of Guidelines for OSteoArthritis in West-Africa (JIGSAW-A). Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austira

169 AGGRECANASE-1 ACTIVITY IN THE SYNOVIAL FLUID OF CARTILAGE INJURY CELL THERAPY TRIAL COHORT PREDICTS OUTCOME 1-YEAR POST TREATMENT. (2024)
Presentation / Conference
Rix, L., Hulme, C. H., Kuiper, J. H., Mennan, C., Gallacher, P., Jermin, P., & Wright, K. T. (2024, January). 169 AGGRECANASE-1 ACTIVITY IN THE SYNOVIAL FLUID OF CARTILAGE INJURY CELL THERAPY TRIAL COHORT PREDICTS OUTCOME 1-YEAR POST TREATMENT. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Genetic Loss of miR-205 Causes Increased Mammary Gland Development (2023)
Journal Article
Cataldo, A., Cheung, D. G., Hagan, J. P., Fassan, M., Sandhu-Deol, S., Croce, C. M., …Iorio, M. V. (in press). Genetic Loss of miR-205 Causes Increased Mammary Gland Development. Non-Coding RNA, 10(1), Article 4. https://doi.org/10.3390/ncrna10010004

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in differ... Read More about Genetic Loss of miR-205 Causes Increased Mammary Gland Development.

Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques (2023)
Thesis
Xie, B. (2023). Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674529

Non-degradable and biodegradable implants inevitably generate debris or degradation products in the body, and these induce acute and chronic inflammation. Polyglycolic acid (PGA) is a simple linear aliphatic polyester with a wide set of medical appli... Read More about Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques.

Quadriceps Tendon Tears Rehabilitation: A Narrative Review of the Literature (2023)
Journal Article
Oliva, F., Marsilio, E., Cuozzo, F., & Maffulli, N. (in press). Quadriceps Tendon Tears Rehabilitation: A Narrative Review of the Literature. M.L.T.J. Muscles, Ligaments and Tendons Journal, 13(04), 667. https://doi.org/10.32098/mltj.04.2023.20

Introduction. Knee extensor apparatus tears are uncommon conditions, affecting middle aged men more than women. Quadriceps tendon ruptures are usually described as an acute consequence of a trauma that could be characterized by a direct or indirect m... Read More about Quadriceps Tendon Tears Rehabilitation: A Narrative Review of the Literature.