Outputs (2257)

Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society (2018)
Journal Article
Mamas, M., Tosh, J., Hulme, W., Hoskins, N., Bungey, G., Ludman, P., de Belder, M., Shing Kwok, C., Verin, N., Kinnaird, T., Bennett, E., Curzen, N., Nolan, J., & Kontopantelis, E. (2018). Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society. Circulation: Cardiovascular Quality and Outcomes, 11(5), https://doi.org/10.1161/circoutcomes.117.004482

Background: Transradial access (TRA) for percutaneous coronary intervention (PCI) is associated with a reduced risk of mortality compared with transfemoral access, access site–related bleeding complications, and shorter length of stay. The budget imp... Read More about Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society.

Study of the measurement and predictive validity of the Functional Movement Screen (2018)
Journal Article
Philp, F., Blana, D., Chadwick, E. K., Stewart, C., Stapleton, C., Major, K., & Pandyan, A. D. (2018). Study of the measurement and predictive validity of the Functional Movement Screen. BMJ Open Sport & Exercise Medicine, 4(1), Article e000357

Objective: The aim of the study was to evaluate the reported measurement capabilities and predictive validity of the Functional Movement Screen (FMS) for injury. Methods: This was a prospective observational longitudinal study of 24 male footballers... Read More about Study of the measurement and predictive validity of the Functional Movement Screen.

Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation (2018)
Journal Article
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., Peffers, M., Shirran, S., Botting, C., & Wright, K. (2018). Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Research and Therapy, 20, Article 87. https://doi.org/10.1186/s13075-018-1573-4

Background
Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternativ... Read More about Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation.

Greater rate of cephalic screw mobilisation following proximal femoral nailing in hip fractures with a tip-apex distance (TAD) and a calcar referenced TAD greater than 25 mm. (2018)
Journal Article
(2018). Greater rate of cephalic screw mobilisation following proximal femoral nailing in hip fractures with a tip-apex distance (TAD) and a calcar referenced TAD greater than 25 mm. Journal of Orthopaedic Surgery and Research, 106 - ?. https://doi.org/10.1186/s13018-018-0814-1

BACKGROUND: To ascertain whether the tip-apex distance (TAD), calcar referenced TAD (CalTAD), and the sum of both (TADcalTAD) are predictive measurements of mobilisation of the cephalic screw in patients with trochanteric hip fractures. METHODS: Betw... Read More about Greater rate of cephalic screw mobilisation following proximal femoral nailing in hip fractures with a tip-apex distance (TAD) and a calcar referenced TAD greater than 25 mm..

Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. (2018)
Journal Article
Kuiper, J., & Wright, K. (2018). Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. European cells & materials, 255 - 267. https://doi.org/10.22203/eCM.v035a18

High hopes have been pinned on regenerative medicine strategies in order to prevent the progression of cartilage damage to osteoarthritis, particularly by autologous chondrocyte implantation (ACI). The loss of chondrocyte phenotype during in vitro mo... Read More about Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy..

Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis (2018)
Journal Article
Eustace, A., King, S., Sessions, R., Kay, A., Farris, M., Broadbridge, R., Kehoe, O., Kungl, A., Middleton, J., & McNaughton, E. (2018). Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis. The Journal of Immunology, 3201-3217. https://doi.org/10.4049/jimmunol.1701187

Inflammation is characterized by the infiltration of leukocytes from the circulation and into the inflamed area. Leukocytes are guided throughout this process by chemokines. These are basic proteins that interact with leukocytes to initiate their act... Read More about Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis.

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice (2018)
Journal Article
Walter, L. M., Deguise, M.-O., Meijboom, K. E., Betts, C. A., Ahlskog, N., van Westering, T. L., Hazell, G., McFall, E., Kordala, A., Hammond, S. M., Abendroth, F., Murray, L. M., Shorrock, H. K., Prosdocimo, D. A., Haldar, S. M., Jain, M. K., Gillingwater, T. H., Claus, P., Kothary, R., Wood, M. J., & Bowerman, M. (2018). Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice. EBioMedicine, 226-242. https://doi.org/10.1016/j.ebiom.2018.04.024

The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a... Read More about Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice.

Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology (2018)
Journal Article
Mamas. (2018). Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 853-872. https://doi.org/10.1002/ejhf.1170

The coexistence of type 2 diabetes mellitus (T2DM) and heart failure (HF), either with reduced (HFrEF) or preserved ejection fraction (HFpEF), is frequent (30–40% of patients) and associated with a higher risk of HF hospitalization, all-cause and car... Read More about Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology.

Characterisation of synovial fluid cells of early osteoarthritis patients (2018)
Journal Article
Garcia, J., Mennan, C., Roberts, S., Richardson, J., Gallagher, P., & Wright, K. (2018). Characterisation of synovial fluid cells of early osteoarthritis patients. Osteoarthritis and Cartilage, 26(S1), S128-S129. https://doi.org/10.1016/j.joca.2018.02.279

The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models (2018)
Journal Article
Yang. (2018). The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models. Colloids and Surfaces B: Biointerfaces, https://doi.org/10.1016/j.colsurfb.2018.04.060

The purpose of this work was to investigate if the biomimetically conjugated VEGF and HUVECs co-culture could modulate the osteogenic and angiogenic differentiation of MSCs derived from rat and human bone marrow (rMSCs and hMSCs). After treated by am... Read More about The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models.