Outputs (2257)

Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes (2018)
Thesis
Elttayef, A. A. J. Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411158

The islets of Langerhans are multicellular aggregates within the pancreas containing beta cells that sense changes in blood glucose level and respond by secreting insulin. The cells within the islets communicate with each other through gap junctions.... Read More about Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes.

The validation of the Royal Stoke Pharmacy Workforce Calculator – a mixed methods study (2018)
Thesis
Bednall, R. The validation of the Royal Stoke Pharmacy Workforce Calculator – a mixed methods study. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411143

Background
The Royal Stoke Pharmacy Workforce Calculator (RSPWC) was developed to meet a local need of identifying clinical pharmacy staffing levels, not described nationally. This study demonstrates the validity and transferability of the RSPWC an... Read More about The validation of the Royal Stoke Pharmacy Workforce Calculator – a mixed methods study.

Validating models of injury risk prediction in football players (2018)
Thesis
Philp, F. D. Validating models of injury risk prediction in football players. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411140

Association football (soccer) is a popular sport and there is a high risk of injury for participants. Within the context of professional clubs, the risk of injury is also associated with the risk of financial costs. Therefore, injury reduction proces... Read More about Validating models of injury risk prediction in football players.

The Stabilizing Function of Superficial Shoulder Muscles Changes Between Single-Plane Elevation and Reaching Tasks (2018)
Journal Article
Ameln, D. J. D., Chadwick, E. K., Blana, D., & Murgia, A. (2019). The Stabilizing Function of Superficial Shoulder Muscles Changes Between Single-Plane Elevation and Reaching Tasks. IEEE Transactions on Biomedical Engineering, 66(2), 564-572. https://doi.org/10.1109/TBME.2018.2850522

Objective: The goal of the current study was to determine whether and how much the stabilizing role of the shoulder muscles changes as a function of humeral elevation and the plane of elevation.

Methods: A musculoskeletal model, comprising a perso... Read More about The Stabilizing Function of Superficial Shoulder Muscles Changes Between Single-Plane Elevation and Reaching Tasks.

Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children (2018)
Journal Article
Gilchrist. (2018). Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children. Physiological Reports, e13752. https://doi.org/10.14814/phy2.13752

Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breat... Read More about Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children.

Long non-coding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines (2018)
Journal Article
(2018). Long non-coding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines. Bioscience Reports, https://doi.org/10.1042/BSR20180704

The lncRNA Myocardial Infarction Associated Transcript (MIAT) is involved in a number of diseases, including myocardial infarction and diabetic retinopathy. Emerging evidence suggests that MIAT expression levels are increased in different type of can... Read More about Long non-coding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines.

Virtual patient educational programme to teach counselling to clinical pharmacists: development and proof of concept (2018)
Journal Article
Richardson, C. L., Chapman, S., & White, S. (2019). Virtual patient educational programme to teach counselling to clinical pharmacists: development and proof of concept. BMJ Simulation and Technology Enhanced Learning, 5(3), 167-169. https://doi.org/10.1136/bmjstel-2018-000352

Pharmacist–patient counselling can benefit patients and optimise care, but appropriate training is required. A virtual patient (VP) tool to teach pharmacists non-vitamin K oral anticoagulant counselling was developed; the VP may be used for continuin... Read More about Virtual patient educational programme to teach counselling to clinical pharmacists: development and proof of concept.

AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial (2018)
Presentation / Conference Contribution
Schmid, P., Abraham, J., Chan, S., Wheatley, D., Brunt, M., Nemsadze, G., Baird, R., Hee Park, Y., Hall, P., Perren, T., Stein, R. C., László, M., Ferrero, J.-M., Phillips, M., Conibear, J., Sarker, S.-J., Prendergast, A., Cartwright, H., Mousa, K., & Turner, N. C. (2018, June). AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial. Presented at 2018 ASCO Annual Meeting I, Chicago, IL, USA

Background: The PI3K/AKT signalling pathway is frequently activated in triple-negative breast cancer (TNBC). AZD5363 is a highly-selective, oral, small molecule AKT inhibitor. The PAKT trial investigated the addition of AZD5363 to paclitaxel as 1st-l... Read More about AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial.

Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation (2018)
Journal Article
(2018). Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation. Nanomedicine: Nanotechnology, Biology and Medicine, 1149-1159. https://doi.org/10.1016/j.nano.2018.02.008

Stem cell therapies hold potential to stimulate tendon regeneration and homeostasis, which is maintained in response to the native mechanical environment. Activins are members of the mechano-responsive TGF-ß superfamily that participates in the regul... Read More about Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation.

An evaluation of paracetamol and ibuprofen prescribing at three high-spend GP practices in Sandwell and West Birmingham: A prescribing analysis study (2018)
Presentation / Conference Contribution
Clayton, R., Vadher, N., White, S., & Chapman, S. (2018, January). An evaluation of paracetamol and ibuprofen prescribing at three high-spend GP practices in Sandwell and West Birmingham: A prescribing analysis study. Presented at ANNUAL CONFERENCE 2018, NATIONAL COUNCIL FOR VOLUNTARY ORGANISATIONS, LONDON, UK

Background
Paracetamol and ibuprofen are readily available without prescription for relief of pain and pyrexia caused by minor, self-limiting conditions. This study was part of Sandwell and West Birmingham Clinical Commissioning Group’s approach to... Read More about An evaluation of paracetamol and ibuprofen prescribing at three high-spend GP practices in Sandwell and West Birmingham: A prescribing analysis study.