Outputs (2257)

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy (2018)
Journal Article
Al-Shakarchi, W., Alsuraifi, A., Curtis, A., & Hoskins, C. (2018). Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10020063

Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook. Combination therapies have been studied in order to evaluate whether increase... Read More about Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy.

Evaluation of a pharmacist-led diabetes educational outreach programme (2018)
Presentation / Conference Contribution
Hin Lai, U., Patel, B., White, S., & Chapman, S. (2018, January). Evaluation of a pharmacist-led diabetes educational outreach programme. Presented at Prescribing and Research in Medicines Management (UK & Ireland), Annual Conference 2018, National Council for Voluntary Organisations, London

Background
Independent Monitoring of Prescribing Analysis Cost Trends (IMPACT) campaigns, also known as educational outreach programmes, involve pharmacists providing training programmes in GP surgeries on prescribing for particular clinical issues... Read More about Evaluation of a pharmacist-led diabetes educational outreach programme.

Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers. (2018)
Journal Article
Winters, Z. E., Horsnell, J., Elvers, K. T., Maxwell, A. J., Jones, L. J., Shaaban, A. M., Schmid, P., Williams, N. R., Beswick, A., Greenwood, R., Ingram, J. C., Saunders, C., Vaidya, J. S., Esserman, L., Jatoi, I., & Brunt, A. M. (2018). Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers. BJS Open, 2(4), 162 - 174. https://doi.org/10.1002/bjs5.53

Background: The clinical effectiveness of treating ipsilateral multifocal (MF) and multicentric (MC) breast cancers using breast-conserving surgery (BCS) compared with the standard of mastectomy is uncertain. Inconsistencies relate to definitions, in... Read More about Systematic review of the impact of breast-conserving surgery on cancer outcomes of multiple ipsilateral breast cancers..

The Influence of Nicotinamide on Health and Disease in the Central Nervous System (2018)
Journal Article
Fricker, R., Green, E., Jenkins, S., & Griffin, S. (2018). The Influence of Nicotinamide on Health and Disease in the Central Nervous System. International Journal of Tryptophan Research, https://doi.org/10.1177/1178646918776658

Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal development, survival, and function in the central nervous system (CNS), being implicated in both neuronal death and neuroprotection. Here, we summarise a bod... Read More about The Influence of Nicotinamide on Health and Disease in the Central Nervous System.

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial (2018)
Journal Article
Roffe. (2018). Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet, 2107-2115. https://doi.org/10.1016/S0140-6736%2818%2931033-X

Background
Tranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage... Read More about Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability (2018)
Journal Article
(2018). Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability. International Journal of Sport Nutrition and Exercise Metabolism, 1 -26. https://doi.org/10.1123/ijsnem.2018-0054

We examined the effects of whey versus collagen protein on skeletal muscle cell signalling responses associated with mitochondrial biogenesis and protein synthesis in recovery from an acute training session completed with low carbohydrate (CHO) avail... Read More about Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability.

The effect of new biosimilars in rheumatology and gastroenterology specialities on UK healthcare budgets: Results of a budget impact analysis (2018)
Journal Article
Aladul, M. I., Fitzpatrick, R. W., & Chapman, S. R. (2019). The effect of new biosimilars in rheumatology and gastroenterology specialities on UK healthcare budgets: Results of a budget impact analysis. Research in Social and Administrative Pharmacy, 15(3), 310-317. https://doi.org/10.1016/j.sapharm.2018.05.009

Background:
The approval of new biosimilars of infliximab, etanercept and adalimumab by the European Medicines Agency is expected to produce further cost savings to the healthcare system budget.

Objectives:
This study aimed to estimate the budg... Read More about The effect of new biosimilars in rheumatology and gastroenterology specialities on UK healthcare budgets: Results of a budget impact analysis.

Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells (2018)
Journal Article
Uche, F., McCullagh, J., Claridge, T., Richardson, A., & Li, W. (2018). Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells. Bioorganic and Medicinal Chemistry Letters, 1652-1656. https://doi.org/10.1016/j.bmcl.2018.03.038

Our previous studies demonstrated that cycleanine, a macrocyclic bisbenzylisoquinoline (BBIQ) alkaloid, showed potent anti-ovarian cancer activity via apoptosis induction. Here, we synthesized two novel (aminoalkyl) cycleanine analogues (2 and 3) thr... Read More about Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells.

Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues (2018)
Journal Article
Reynisson. (2018). Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues. Peptide Science, e24076. https://doi.org/10.1002/pep2.24076

This work demonstrates that the human autophagy 16 polypeptide (Atg16) has antibacterial and antibiofilm potential, perturbs both Gram positive and negative bacterial membranes and subsequently also produces ROS in compromised bacteria. Engineered At... Read More about Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues.

Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society (2018)
Journal Article
Mamas, M., Tosh, J., Hulme, W., Hoskins, N., Bungey, G., Ludman, P., de Belder, M., Shing Kwok, C., Verin, N., Kinnaird, T., Bennett, E., Curzen, N., Nolan, J., & Kontopantelis, E. (2018). Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society. Circulation: Cardiovascular Quality and Outcomes, 11(5), https://doi.org/10.1161/circoutcomes.117.004482

Background: Transradial access (TRA) for percutaneous coronary intervention (PCI) is associated with a reduced risk of mortality compared with transfemoral access, access site–related bleeding complications, and shorter length of stay. The budget imp... Read More about Health economic analysis of access site practice in England during changes in practice: Insights from the British Cardiovascular Interventional Society.