Outputs (86)

P187 Fatigue in people with polymyalgia rheumatica: a key unmet need? (2024)
Presentation / Conference

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. Glucocorticoids treatment generally focusses on reducing pain and stiffness, but there are other... Read More about P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?.

Weight, weight gain and behavioural risk factors in women attending a breast cancer family history, risk and prevention clinic: an observational study (2024)
Journal Article

Background: Weight and health behaviours impact on breast cancer risk. We describe trends in weight and health behaviours in women at entry to a specialist breast cancer family history clinic in Manchester, UK, and changes after clinic entry. Methods... Read More about Weight, weight gain and behavioural risk factors in women attending a breast cancer family history, risk and prevention clinic: an observational study.

Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis (2023)
Journal Article

Background: Systemic inflammation, measured as circulating Interleukin-6 (IL-6) levels, is associated with cardiovascular and all-cause mortality in chronic kidney disease. However, this has not been convincingly demonstrated in a systematic review o... Read More about Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis.

Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial (2023)
Journal Article

Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function (RKF). To establish whether knowledge of the estimated normally hydrated weight from bioimpedance measurements (BI-NHW) when setting the post-hemodialy... Read More about Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial.

Novel capsaicin cough endpoints effectively discriminate between healthy controls and patients with refractory chronic cough (2023)
Journal Article

Rationale Chronic cough is a common problem, substantially affecting quality of life. Effective treatments and diagnostic clinical tools for refractory chronic cough are lacking which remains a diagnosis of exclusion. Objectives To investigate capsai... Read More about Novel capsaicin cough endpoints effectively discriminate between healthy controls and patients with refractory chronic cough.

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care (2022)
Journal Article

Objective To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care. Methods In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices... Read More about Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care.

Prevention Of Breast and Endometrial cancer using Total Diet Replacement (PROBE-TDR) trial: protocol for a randomised controlled trial (2022)
Journal Article

Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR (2022)
Journal Article

OBJECTIVE: With growing recognition of the benefits of preserving residual kidney function (RKF) and use of incremental treatment regimes, the incentive to measure residual clearance in haemodialysis patients is increasing. Interdialytic urine collec... Read More about Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR.

Reply (2021)
Journal Article

'letter'

Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis. (2021)
Journal Article

BACKGROUND: Lung clearance index (LCI) is a valuable research tool in cystic fibrosis (CF) but clinical application has been limited by technical challenges and uncertainty about how to interpret longitudinal change. In order to help inform clinical... Read More about Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis..

Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis (2021)
Journal Article

ObjectiveUrate‐lowering therapy (predominantly allopurinol) is highly effective as a treatment for gout, but its wider long‐term effects remain unclear. This systematic review and meta‐analysis aimed to ascertain the association between mortality and... Read More about Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis.

Non-invasive ventilation is associated with long-term improvements in lung function and gas exchange in cystic fibrosis adults with hypercapnic respiratory failure (2021)
Journal Article

Non-invasive ventilation (NIV) is an established treatment option for cystic fibrosis (CF) patients with type 2 respiratory failure but the benefits of this therapy remain unclear. This study examined the long-term outcomes and response to NIV in a l... Read More about Non-invasive ventilation is associated with long-term improvements in lung function and gas exchange in cystic fibrosis adults with hypercapnic respiratory failure.

Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure (2021)
Journal Article

OBJECTIVES: The purposes of this study were to determine why chronic obstructive pulmonary disease (COPD) is associated with heart failure (HF). Specific objectives included whether COPD is associated with myocardial fibrosis, whether myocardial fibr... Read More about Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure.

Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care (2020)
Journal Article

Objective To investigate the existence of distinct classes of gout flare trajectories and compare their gout-specific, comorbid, and sociodemographic characteristics. Methods In a prospective cohort study, adults with gout who were registered wi... Read More about Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care.

The Effect of Pain Conditioning on Experimentally Evoked Cough: Evidence of Impaired Endogenous Inhibitory Control Mechanisms in Refractory Chronic Cough (2020)
Journal Article

Background: The pathophysiology of refractory chronic cough (RCC) is unclear. We hypothesised that endogenous inhibitory control mechanisms, such as those activated by painful stimuli (conditioned pain modulation (CPM)), may be capable of inhibiting... Read More about The Effect of Pain Conditioning on Experimentally Evoked Cough: Evidence of Impaired Endogenous Inhibitory Control Mechanisms in Refractory Chronic Cough.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. (2020)
Journal Article

OBJECTIVES: Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction..

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care (2020)
Journal Article

Background Gout affects 2.5% of adults in the UK but is often poorly managed. It can impair health-related quality of life (HRQOL), yet little is known about which people with gout are at risk of worse outcomes. We investigated factors associated wi... Read More about P142 Factors associated with change in health-related quality of life in people living with gout: a three-year prospective cohort study in primary care.

Reply to Comment on “The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial” (2020)
Journal Article

Our programme aimed to prevent weight gain in healthy weight women and reduce weight in women who were overweight/obese since both may improve outcome and well-being after a diagnosis of breast cancer (BC).1,2 Women in the community arm received init... Read More about Reply to Comment on “The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial”.

Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study (2019)
Journal Article

Objectives. To investigate potential subgroups of primary care diagnosed patients with polymyalgia rheumatica (PMR) based on self-reported pain and stiffness severity over time. Methods. 652 people with an incident PMR diagnosis were recruited fro... Read More about Longitudinal clusters of pain and stiffness in polymyalgia rheumatica: 2-year results from the PMR Cohort Study.

Characteristics of patients with giant cell arteritis who experience visual symptoms (2019)
Journal Article

Permanent vision loss is one of the most serious complications of giant cell arteritis (GCA) and therefore prompt diagnosis is paramount. However, diagnosis of GCA remains challenging due to its frequently non-specific presentation. Our aim was to id... Read More about Characteristics of patients with giant cell arteritis who experience visual symptoms.

Gender-specific risk factors for gout: a systematic review of cohort studies (2019)
Journal Article

BACKGROUND: Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout. We aimed to systematically review all cohort studies examining risk factors for the development of gout by gend... Read More about Gender-specific risk factors for gout: a systematic review of cohort studies.

202 Gout attack trajectories in a 3-year cohort study in primary care (2019)
Journal Article

Background: Gout affects 2.5% of adults in the UK but is often poorly managed. Whilst the hallmark of gout is recurrent sudden-onset attacks of acute joint pain and swelling, little is known about the pattern (trajectory) of attacks over time. We aim... Read More about 202 Gout attack trajectories in a 3-year cohort study in primary care.

216 Characteristics of patients with prevalent giant cell arteritis in UK primary care (2019)
Journal Article

Background: Giant cell arteritis (GCA) is a rare, but serious condition affecting older people. Prompt diagnosis remains challenging due to non-specific presentations. Furthermore, there are marked variations in GP referral and management approaches.... Read More about 216 Characteristics of patients with prevalent giant cell arteritis in UK primary care.

E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica (2019)
Journal Article

Background: Extended duration of glucocorticoid (GC) therapy can be considered a poor outcome in people with polymyalgia rheumatica (PMR). Being able to predict the likelihood of extended GC therapy at diagnosis would enable earlier specialist referr... Read More about E042 Predicting duration of glucocorticoid therapy in an inception cohort of patients with polymyalgia rheumatica.

Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death (2019)
Journal Article

Background Risk of Encapsulating Peritoneal Sclerosis (EPS) is strongly associated with the duration of peritoneal dialysis (PD), such that patients who have been on PD for some time may consider elective transfer to haemodialysis to mitigate risk o... Read More about Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies (2018)
Journal Article

BACKGROUND: Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hypertension and diuretic use. METHOD... Read More about Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies.

Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported (2018)
Journal Article

Objective Measurement error in predictor variables may threaten the validity of clinical prediction models. We sought to evaluate the possible extent of the problem. A secondary objective was to examine whether predictors are measured at the intende... Read More about Measurement error and timing of predictor values for multivariable risk prediction models are poorly reported.

How common is depression in patients with polymyalgia rheumatica? (2018)
Journal Article

Depression is common in inflammatory disorders such as rheumatoid arthritis and systemic lupus erythematosus and negatively impacts on outcomes. Given the long-term nature of polymyalgia rheumatica (PMR) and its glucocorticoid treatment, these patien... Read More about How common is depression in patients with polymyalgia rheumatica?.

Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial (2018)
Journal Article

OBJECTIVE: To investigate the cost-effectiveness (cost-utility) of introducing general practitioner screening for anxiety and depression in patients consulting with osteoarthritis (OA). METHODS: A cluster-randomised trial-based economic evaluation to... Read More about Cost-Utility Analysis of Routine Anxiety and Depression Screening in Patients Consulting for Osteoarthritis: Results From a Clinical, Randomized Controlled Trial.

Factors Influencing Allopurinol Initiation in Primary Care (2017)
Journal Article

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis (2017)
Journal Article

BACKGROUND: Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study's objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific cha... Read More about Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis.

Public priorities for osteoporosis and fracture research: results from a general population survey (2017)
Journal Article

This is the first national study of public and patient research priorities in osteoporosis and fracture. We have identified new research areas of importance to members of the public, particularly ‘access to information from health professionals’. The... Read More about Public priorities for osteoporosis and fracture research: results from a general population survey.

The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care (2017)
Journal Article

BACKGROUND: This study aimed to evaluate whether prompting general practitioners (GPs) to routinely assess and manage anxiety and depression in patients consulting with osteoarthritis (OA) improves pain outcomes. METHODS AND FINDINGS: We conducted a... Read More about The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteoarthritis Trial): A cluster randomised trial in primary care.

LEVELS OF SALIVARY C-REACTIVE PROTEIN, PROCALCITONIN AND NEUTROPHIL ELASTASE CAN PREDICT EXACERBATIONS IN COPD AND DETERMINE THOSE PATIENTS AT HIGH RISK OF RE-EXACERBATION (2016)
Journal Article

Saliva has numerous practical advantages as a diagnostic bio-sample for management of long term conditions. We have previously demonstrated that C-reactive protein (CRP), procalcitonin (PCT) and neutrophil elastase (NE) can be reliably and reproducib... Read More about LEVELS OF SALIVARY C-REACTIVE PROTEIN, PROCALCITONIN AND NEUTROPHIL ELASTASE CAN PREDICT EXACERBATIONS IN COPD AND DETERMINE THOSE PATIENTS AT HIGH RISK OF RE-EXACERBATION.

PUBLIC PRIORITY SETTING FOR RESEARCH IN OSTEOPOROSIS AND FRACTURE: RESULTS FROM A NATIONAL E-SURVEY (2016)
Presentation / Conference

Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain (2016)
Journal Article

Objective To determine the comparative prevalence, associations with selected patient characteristics, and clinical outcomes of medial and lateral compartment patellofemoral (PF) joint osteoarthritis (OA). Methods Information was collected by qu... Read More about Clinical Significance of Medial Versus Lateral Compartment Patellofemoral Osteoarthritis: Cross-Sectional Analyses in an Adult Population With Knee Pain.

Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study (2016)
Journal Article

Background Patients’ perceptions of their illness are dynamic and can directly influence aspects of management. Our aim was to examine the illness perceptions of gout patients in UK primary care and associations with allopurinol use. Methods A h... Read More about Illness perceptions of gout patients and the use of allopurinol in primary care: baseline findings from a prospective cohort study.

Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care. (2016)
Journal Article

In older adults, reduced social participation increases the risk of poor health-related quality of life, increased levels of inflammatory markers and cardiovascular disease, and increased mortality. Older adults frequently present to primary care, wh... Read More about Widespread pain and depression are key modifiable risk factors associated with reduced social participation in older adults: A prospective cohort study in primary care..

Bayesian inference for joint modelling of longitudinal continuous, binary and ordinal events (2016)
Journal Article

In medical studies, repeated measurements of continuous, binary and ordinal outcomes are routinely collected from the same patient. Instead of modelling each outcome separately, in this study we propose to jointly model the trivariate longitudinal re... Read More about Bayesian inference for joint modelling of longitudinal continuous, binary and ordinal events.

Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach. (2016)
Journal Article

OBJECTIVE: Clinical outcomes in rheumatoid arthritis (RA) are improved if the disease is treated early. However, treatment is often significantly delayed as a result of delayed help-seeking by patients who fail to recognise its symptoms or the need f... Read More about Symptom recognition and perceived urgency of help-seeking for rheumatoid arthritis and other diseases in the general public: A mixed method approach..

DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS (2016)
Journal Article

Background The diagnosis of giant cell arteritis (GCA) remains difficult, with patients often presenting with non-specific and atypical symptoms. Such ambiguity can lead to delays in the diagnosis of GCA, which in-turn may result in the patient exper... Read More about DIAGNOSTIC DELAY FOR GIANT CELL ARTERITIS (GCA). A SYSTEMATIC REVIEW AND META-ANALYSIS.

PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY (2016)
Journal Article

Background Polymyalgia rheumatica (PMR) is a common inflammatory disorder of older (>50 years) adults, frequently managed in primary care. PMR remains under-researched despite the significant impact this condition has on patient's quality of life. Ex... Read More about PATIENT PRIORITIES FOR PMR RESEARCH: A PRIMARY CARE SURVEY.

SYMPTOM RECOGNITION AND ITS EFFECT ON HELP-SEEKING IN RHEUMATOID ARTHRITIS, BOWEL CANCER AND ANGINA: A MIXED METHODS APPROACH (2016)
Presentation / Conference

Background Rheumatoid arthritis (RA) requires treatment in its earliest stages in order to reduce the likelihood of permanent joint damage and disability. However, this therapeutic window is often missed as a result of delayed help-seeking by patient... Read More about SYMPTOM RECOGNITION AND ITS EFFECT ON HELP-SEEKING IN RHEUMATOID ARTHRITIS, BOWEL CANCER AND ANGINA: A MIXED METHODS APPROACH.

Virtual imaging for patient information on radiotherapy planning and delivery (2016)
Presentation / Conference

Purpose or Objective: To assess whether both patients and their relatives would welcome further information on a oneto-one basis on RT planning and delivery using the virtual reality (VR) system VERT.

O21 The Impact of Symptom Recognition on Help-Seeking: A Comparison Between Rheumatoid Arthritis, Bowel Cancer and Angina (2016)
Presentation / Conference

Background: RA requires early treatment to reduce the risk of joint damage and disability. However, due to delays at various points in the patient’s journey following symptom onset, this therapeutic window is often missed. Patients themselves are an... Read More about O21 The Impact of Symptom Recognition on Help-Seeking: A Comparison Between Rheumatoid Arthritis, Bowel Cancer and Angina.

047 Obesity, Hypertension and Diuretic Use as Risk Factors for Incident Gout: A Meta-Analysis of Cohort Studies (2016)
Journal Article

COMPARATIVE FREQUENCY OF MEDIAL VERSUS LATERAL COMPARTMENT PATELLOFEMORAL JOINT OSTEOARTHRITIS AND ASSOCIATIONS WITH RISK FACTORS AND CLINICAL OUTCOMES: CROSS-SECTIONAL ANALYSES IN AN ADULT POPULATION WITH KNEE PAIN (2016)
Conference Proceeding

Evaluating three hundred and fifty-two admissions and predictors of re-admissions for epistaxis - is it time to re-evaluate tranexamic acid in epistaxis? (2015)
Journal Article

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Clustering of pain and its associations with health in people aged 50 years and older: cross-sectional results from the North Staffordshire Osteoarthritis Project (2015)
Journal Article

Objective Most pain in patients aged =50 years affects multiple sites and yet the predominant mode of presentation is single-site syndromes. The aim of this study was to investigate if pain sites form clusters in this population and if any such clust... Read More about Clustering of pain and its associations with health in people aged 50 years and older: cross-sectional results from the North Staffordshire Osteoarthritis Project.

One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. (2015)
Journal Article

OBJECTIVE: Distinguishing transient from persistent anxiety and depression symptoms in older people presenting to general practice with musculoskeletal pain is potentially important for effective management. This study sought to identify distinct pos... Read More about One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis..

Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters (2015)
Journal Article

BACKGROUND: Saliva is increasingly promoted as an alternative diagnostic bio-sample to blood; however its role in respiratory disease requires elucidation. Our aim was to investigate whether C-reactive protein (CRP), procalcitonin (PCT) and neutrophi... Read More about Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters.

Methods for modeling stroke outcome data over time (2015)
Conference Proceeding

O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink (2015)
Journal Article

Background: Current evidence suggests that gout is an independent risk factor for excess cardiovascular morbidity and mortality; yet, suboptimal care for patients with gout in primary care persists. We aimed to identify risk factors specific to these... Read More about O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink.

Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies (2015)
Journal Article

ntroduction To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis. Methods Systematic review and meta-... Read More about Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies.

Pilot study on virtual imaging for patient information on radiotherapy planning and delivery (2015)
Journal Article

It is widely accepted that health professionals might sometimes underestimate cancer patients' needs for information on the complex process of radiotherapy (RT) planning and delivery. Furthermore, relatives might also feel excluded from the treatment... Read More about Pilot study on virtual imaging for patient information on radiotherapy planning and delivery.

Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis (2015)
Journal Article

BACKGROUND: Hyperuricaemia, the biochemical precursor to gout, has been shown to be an independent risk factor for mortality from cardiovascular disease (CVD), although studies examining the clinical phenomenon of gout and risk of CVD mortality repor... Read More about Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis.

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink (2015)
Journal Article

OBJECTIVES: To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studi... Read More about Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink.

Response to: 'Risk of vascular disease with gout: overadjustment of the statistical analyses?' by van Durme et al. (2015)
Journal Article

THE INCIDENCE OF NEW PSEUDOMONAS AERUGINOSA INFECTION IN CHILDREN WITH CYSTIC FIBROSIS (2014)
Presentation / Conference

Introduction Pseudomonas aeruginosa (PA) is one of the most important pathogens in cystic fibrosis (CF). Although there is a wealth of data about the prevalence of chronic PA infection, there is a paucity of evidence about the incidence of new PA inf... Read More about THE INCIDENCE OF NEW PSEUDOMONAS AERUGINOSA INFECTION IN CHILDREN WITH CYSTIC FIBROSIS.

EVALUATION OF SALIVA BIOMARKERS AS INDICATORS OF HEALTH STATUS AND EXACERBATIONS IN COPD (2014)
Journal Article

Saliva is increasingly promoted as a suitable alternative diagnostic bio-sample to blood, yet its role in respiratory disease is still to be elucidated. Salivary levels of C-Reactive Protein (CRP), Procalcitonin (PCT) and Neutrophil Elastase (NE)... Read More about EVALUATION OF SALIVA BIOMARKERS AS INDICATORS OF HEALTH STATUS AND EXACERBATIONS IN COPD.

Risk of vascular events in patients with polymyalgia rheumatica. (2014)
Journal Article

BACKGROUND: Polymyalgia rheumatica is one of the most common inflammatory rheumatologic conditions in older adults. Other inflammatory rheumatologic disorders are associated with an excess risk of vascular disease. We investigated whether polymyalgia... Read More about Risk of vascular events in patients with polymyalgia rheumatica..

Developing Objective Metrics for Unit Staffing (DOMUS) study (2014)
Journal Article

Objective Safe midwifery staffing levels on delivery suites is a priority area for any maternity service. Escalation policies are tools that provide an operational response to emergency pressures. The aim of this study was to assess the feasibility o... Read More about Developing Objective Metrics for Unit Staffing (DOMUS) study.

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink (2014)
Journal Article

Objectives To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studie... Read More about Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink.

Is cancer associated with polymyalgia rheumatica?: A cohort study in the General Practice Research Database (2014)
Journal Article

OBJECTIVE: To investigate the incidence of new cancer diagnoses in a community sample of patients with polymyalgia rheumatica (PMR). METHODS: All incident cases of PMR in the UK General Practice Research Database (GPRD) (1987-99), without pre-existin... Read More about Is cancer associated with polymyalgia rheumatica?: A cohort study in the General Practice Research Database.

Pain at multiple body sites and health-related quality of life in older adults: results from the North Staffordshire Osteoarthritis Project. (2014)
Journal Article

OBJECTIVES: Number of pain sites (NPS) is a potentially important marker of health-related quality of life (HRQoL) but remains unexplored in older people. This cross-sectional study investigated whether, in older people including the oldest old, NPS... Read More about Pain at multiple body sites and health-related quality of life in older adults: results from the North Staffordshire Osteoarthritis Project..

195. Does Intra-Articular Corticosteroid Injection in the Pre-Operative Period Increase the Risk of Joint Infection Following Hip or Knee Arthroplasty? A Systematic Review and Meta-Analysis (2014)
Journal Article

Background: OA is the commonest arthritis, and is increasing in prevalence. NICE OA guidelines include IA corticosteroid injections as an adjunctive treatment. There are theoretical concerns that their use prior to joint replacement surgery may incre... Read More about 195. Does Intra-Articular Corticosteroid Injection in the Pre-Operative Period Increase the Risk of Joint Infection Following Hip or Knee Arthroplasty? A Systematic Review and Meta-Analysis.

Health services changes: is a run-in period necessary before evaluation in randomised clinical trials? (2014)
Journal Article

BACKGROUND: Most randomised clinical trials (RCTs) testing a new health service do not allow a run-in period of consolidation before evaluating the new approach. Consequently, health professionals involved may feel insufficiently familiar or confiden... Read More about Health services changes: is a run-in period necessary before evaluation in randomised clinical trials?.

GOUT IS AN INDEPENDENT RISK FACTOR FOR ALL TYPES OF VASCULAR DISEASE: A RETROSPECTIVE COHORT STUDY IN THE UK GENERAL PRACTICE RESEARCH DATABASE (2013)
Presentation / Conference

Point-of-Care Prognosis for Common Musculoskeletal Pain in Older Adults (2013)
Journal Article

Importance Many site-specific, multivariable risk models for predicting the outcome of musculoskeletal pain problems have been published. The overlapping content in these models suggests a common set of generic indicators suitable for use in primary... Read More about Point-of-Care Prognosis for Common Musculoskeletal Pain in Older Adults.

Statin Use and Osteoarthritis (2013)
Journal Article

The Authors’ Reply—We thank Dr Rashid for highlighting the importance our findings,1 as well as the wider generic implications that relate to common treatment pathways and shared mechanisms in the pathogenesis of chronic diseases such as cardiovascul... Read More about Statin Use and Osteoarthritis.

PL.20 Perineal Assessment and Repair E-Learning System (ePEARLS): An E-Learning Training Package to Improve Clinical Management of Perineal Trauma Following Childbirth (2013)
Presentation / Conference

Background Birth related perineal trauma can have a major impact on women’s health. The correct assessment and repair of perineal injuries are procedures that require knowledge and skill. Currently, there is no agreement as to what constitutes an eff... Read More about PL.20 Perineal Assessment and Repair E-Learning System (ePEARLS): An E-Learning Training Package to Improve Clinical Management of Perineal Trauma Following Childbirth.

O30. The Risk of a Subsequent Cancer Diagnosis after PMR: A Primary Care Database Study (2013)
Presentation / Conference

Background: PMR is the commonest inflammatory rheumatological disorder managed in primary care. Other inflammatory conditions such as RA and psoriasis have been associated with an increased incidence of cancer, specifically haematological malignancie... Read More about O30. The Risk of a Subsequent Cancer Diagnosis after PMR: A Primary Care Database Study.

The development and validation of an internet-based training package for the management of perineal trauma following childbirth: MaternityPEARLS (2013)
Journal Article

Statin Use and Clinical Osteoarthritis in the General Population: A Longitudinal Study (2013)
Journal Article

BACKGROUND: One hypothesis has posited whether abnormal lipid metabolism might be a causal factor in the pathogenesis of osteoarthritis (OA). Routine statin use in clinical practice provides the basis for a natural experiment in testing this hypothes... Read More about Statin Use and Clinical Osteoarthritis in the General Population: A Longitudinal Study.

The risk of a subsequent cancer diagnosis after herpes zoster infection: primary care database study (2013)
Journal Article

Background: Herpes zoster and cancer are associated with immunosuppression. Zoster occurs more often in patients with an established cancer diagnosis. Current evidence suggests some risk of cancer after zoster but is inconclusive. We aimed to assess... Read More about The risk of a subsequent cancer diagnosis after herpes zoster infection: primary care database study.

Does life course socio-economic position influence chronic disabling pain in older adults? A general population study (2012)
Journal Article

Background Chronic pain is the leading cause of disability in developed countries. Prevalence is linked with socio-economic position (SEP), but little is known about the influence of SEP on disabling pain over the life course. We have investigated t... Read More about Does life course socio-economic position influence chronic disabling pain in older adults? A general population study.

The effectiveness of national guidance in changing analgesic prescribing in primary care from 2002 to 2009: an observational database study (2012)
Journal Article

BACKGROUND: Numerous national guidelines have been issued to assist general practitioners' safe analgesic prescribing. Their effectiveness is unclear. The objective of this study was to examine trends in general practitioners' prescribing behaviour i... Read More about The effectiveness of national guidance in changing analgesic prescribing in primary care from 2002 to 2009: an observational database study.

Association between polymyalgia rheumatica and vascular disease: A systematic review (2012)
Journal Article

Objective To systematically identify and appraise the existing literature on the association between polymyalgia rheumatica (PMR) and vascular disease. Methods The Medline, Embase, CINAHL, and Cochrane databases were searched from inception to S... Read More about Association between polymyalgia rheumatica and vascular disease: A systematic review.

The clinical assessment study of the foot (CASF): study protocol for a prospective observational study of foot pain and foot osteoarthritis in the general population. (2011)
Journal Article

BACKGROUND: Symptomatic osteoarthritis (OA) affects approximately 10% of adults aged over 60 years. The foot joint complex is commonly affected by OA, yet there is relatively little research into OA of the foot, compared with other frequently affecte... Read More about The clinical assessment study of the foot (CASF): study protocol for a prospective observational study of foot pain and foot osteoarthritis in the general population..

042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners
Presentation / Conference

Background: Early treatment can reduce morbidity and mortality in patients with RA. However, identifying early RA can be challenging, in part because many of its initial symptoms are non-specific. Delays in recognising RA and referral to secondary ca... Read More about 042 Challenges Faced in Primary Care During the Early Stages of Rheumatoid Arthritis: A Cross-Sectional Survey of General Practitioners.

THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis
Journal Article

Background Rheumatoid arthritis (RA) should be treated with DMARDs in its earliest stages to reduce the likelihood of permanent joint damage and disability1. This therapeutic window is often missed. One important cause is delayed help seeking by pati... Read More about THU0650 Early help seeking or self-management: a quantitative assessment in the context of rheumatoid arthritis.