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Everyday Living with Osteoarthritis in the Global South: A qualitative focus group inquiry in Nigeria. (2024)
Journal Article
Owoyemi, T., Alonge, I., Adetunji, O., Ogbu, E., Ogunbanjo, A., White, S., …Dziedzic, K. (2024). Everyday Living with Osteoarthritis in the Global South: A qualitative focus group inquiry in Nigeria. Osteoarthritis and Cartilage Open, Article 100555. https://doi.org/10.1016/j.ocarto.2024.100555

Objective
Africa contributes significantly to the increasing global prevalence (>37%), unmet need and treatment burden for people with osteoarthritis. Despite this, little research has examined the expressed needs of patients with osteoarthritis (OA... Read More about Everyday Living with Osteoarthritis in the Global South: A qualitative focus group inquiry in Nigeria..

Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT) (2024)
Journal Article
Farooq, S., Hattle, M., Kingstone, T., Ajnakina, O., Dazzan, P., Demjaha, A., …Riley, R. D. (2024). Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT). British Journal of Psychiatry, 1-10. https://doi.org/10.1192/bjp.2024.101

Background
A clinical tool to estimate the risk of treatment-resistant schizophrenia (TRS) in people with first-episode psychosis (FEP) would inform early detection of TRS and overcome the delay of up to 5 years in starting TRS medication.

Aims... Read More about Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT).

Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare (2024)
Journal Article
Archer, L., Peat, G., Snell, K. I. E., Hill, J. C., Dunn, K. M., Foster, N. E., …Wynne-Jones, G. (2024). Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare. Journal of Occupational Rehabilitation, https://doi.org/10.1007/s10926-024-10223-w

Purpose
To develop and validate prediction models for the risk of future work absence and level of presenteeism, in adults seeking primary healthcare with musculoskeletal disorders (MSD).

Methods
Six studies from the West-Midlands/Northwest regi... Read More about Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare.

Management of Refractory Disease and Persistent Symptoms in Inflammatory Arthritis: Qualitative Framework analysis of interviews with patients and healthcare professionals (2024)
Journal Article
Chaplin, H., Simpson, C., Wilkins, K., Meehan, J., Ng, N., Galloway, J., …Norton, S. (2024). Management of Refractory Disease and Persistent Symptoms in Inflammatory Arthritis: Qualitative Framework analysis of interviews with patients and healthcare professionals. Rheumatology Advances in Practice, 8(3), Article rkae076. https://doi.org/10.1093/rap/rkae076

Objectives
This study aims to explore patients’ and clinicians’ experiences in managing and living with refractory disease (RD) and persistent physical and emotional symptoms (PPES) in patients with RA or polyarticular JIA from their perspectives th... Read More about Management of Refractory Disease and Persistent Symptoms in Inflammatory Arthritis: Qualitative Framework analysis of interviews with patients and healthcare professionals.

Scalable Transdiagnostic Early Assessment of Mental Health (STREAM): a study protocol. (2024)
Journal Article
Williams, E. H., Thompson, N. M., McCray, G., Crespo-Llado, M. M., Bhavnani, S., Gajria, D., …Chakrabarti, B. (2024). Scalable Transdiagnostic Early Assessment of Mental Health (STREAM): a study protocol. BMJ Open, 14(6), Article e088263. https://doi.org/10.1136/bmjopen-2024-088263

Early childhood development forms the foundations for functioning later in life. Thus, accurate monitoring of developmental trajectories is critical. However, such monitoring often relies on time-intensive assessments which necessitate administration... Read More about Scalable Transdiagnostic Early Assessment of Mental Health (STREAM): a study protocol..

Prognostic Factors and Models for Predicting Work Absence in Adults with Musculoskeletal Conditions Consulting a Healthcare Practitioner: A Systematic Review. (2024)
Journal Article
Wynne-Jones, G., Wainwright, E., Goodson, N., Jordan, J., Legha, A., Parchment, M., …Peat, G. (2024). Prognostic Factors and Models for Predicting Work Absence in Adults with Musculoskeletal Conditions Consulting a Healthcare Practitioner: A Systematic Review. Journal of Occupational Rehabilitation, https://doi.org/10.1007/s10926-024-10205-y

It is difficult to predict which employees, in particular those with musculoskeletal pain, will return to work quickly without additional vocational advice and support, which employees will require this support and what levels of support are most app... Read More about Prognostic Factors and Models for Predicting Work Absence in Adults with Musculoskeletal Conditions Consulting a Healthcare Practitioner: A Systematic Review..

Calibration plots for multistate risk predictions models (2024)
Journal Article
Pate, A., Sperrin, M., Riley, R. D., Peek, N., Van Staa, T., Sergeant, J. C., …Martin, G. P. (in press). Calibration plots for multistate risk predictions models. Statistics in Medicine, https://doi.org/10.1002/sim.10094

Introduction
There is currently no guidance on how to assess the calibration of multistate models used for risk prediction. We introduce several techniques that can be used to produce calibration plots for the transition probabilities of a multistat... Read More about Calibration plots for multistate risk predictions models.

Development of the Community-based complex Interventions to sustain Independence in Older People (CII-OP) typology: a qualitative synthesis of interventions in randomised controlled trials (2024)
Journal Article
Crocker, T. F., Jordão, M., Lam, N., Ramiz, R., Mirza, L., Patel, I., …Walford, R. (2024). Development of the Community-based complex Interventions to sustain Independence in Older People (CII-OP) typology: a qualitative synthesis of interventions in randomised controlled trials. Age and ageing, 53(5), 1-13. https://doi.org/10.1093/ageing/afae102

Introduction Community-based services to sustain independence for older people have varying configurations. A typology of these interventions would improve service provision and research by providing conceptual clarity and enabling the identification... Read More about Development of the Community-based complex Interventions to sustain Independence in Older People (CII-OP) typology: a qualitative synthesis of interventions in randomised controlled trials.

Health and lifestyle advice in community pharmacy for musculoskeletal conditions: a focused ethnography (2024)
Journal Article
Long, A., O’Brien, N., Rapley, T., & Dziedzic, K. (2024). Health and lifestyle advice in community pharmacy for musculoskeletal conditions: a focused ethnography. International Journal of Pharmacy Practice, 32(Supplement_1), i4-i4. https://doi.org/10.1093/ijpp/riae013.005

Introduction Musculoskeletal health conditions are common, painful, and disabling, and often occur alongside other long-term conditions. Around a third of the UK population live with a musculoskeletal condition placing a huge burden on health and soc... Read More about Health and lifestyle advice in community pharmacy for musculoskeletal conditions: a focused ethnography.

Early Intervention in Psychosis and Management of First Episode Psychosis in Low- and Lower-Middle-Income Countries: A Systematic Review (2024)
Journal Article
Farooq, S., Fonseka, N., Wajid Ali, M., Milner, A., Hamid, S., Sheikh, S., …Ayub, M. (2024). Early Intervention in Psychosis and Management of First Episode Psychosis in Low- and Lower-Middle-Income Countries: A Systematic Review. Schizophrenia Bulletin, Article sbae025. https://doi.org/10.1093/schbul/sbae025

Background and Hypothesis People with first-episode psychosis (FEP) in low- and lower-middle-income countries (LMIC) experience delays in receiving treatment, resulting in poorer outcomes and higher mortality. There is robust evidence for effective a... Read More about Early Intervention in Psychosis and Management of First Episode Psychosis in Low- and Lower-Middle-Income Countries: A Systematic Review.

Demographic, health, physical activity, and workplace factors are associated with lower healthy working life expectancy and life expectancy at age 50 (2024)
Journal Article
Lynch, M., Bucknall, M., Jagger, C., Kingston, A., & Wilkie, R. (2024). Demographic, health, physical activity, and workplace factors are associated with lower healthy working life expectancy and life expectancy at age 50. Scientific Reports, 14(1), Article 5936. https://doi.org/10.1038/s41598-024-53095-z

Although retirement ages are rising in the United Kingdom and other countries, the average number of years people in England can expect to spend both healthy and work from age 50 (Healthy Working Life Expectancy; HWLE) is less than the number of year... Read More about Demographic, health, physical activity, and workplace factors are associated with lower healthy working life expectancy and life expectancy at age 50.

Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage (2024)
Journal Article
Toader, A., Campbell, M. K., Quint, J. K., Robling, M., Sydes, M. R., Thorn, J., …Williamson, P. (in press). Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage. Trials, 25(1), https://doi.org/10.1186/s13063-024-07926-z

Background
Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, issues to be considered before t... Read More about Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.

The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins. (2024)
Journal Article
Dissanayake, L., Herath, B., Opatha, J., Jabir, S., Siriwardana, R., Sirisena, K., …Rijsdijk, F. (in press). The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins. Behavior Genetics, 54(1), 63–72. https://doi.org/10.1007/s10519-023-10171-w

Nutrition and diet are key modifiable risk factors for the rising burden of non-communicable diseases like cardio-vascular diseases and diabetes in low- and middle- income countries (LMICs). The nutritional transition in dietary behaviours in LMICs h... Read More about The Colombo Twin and Singleton Study (COTASS): Piloting the Feasibility of Collecting Nutritional Data and Extension of the Sample to Include Children of Twins..

Impact of the COVID-19 pandemic on young people living with HIV in Lesotho: a qualitative study (2024)
Journal Article
Shepherd, T., Robinson, M. E., Ramaema, M., Rakuoane, M., Moletsane, N., Mpholo, R., …Leigh, G. (2024). Impact of the COVID-19 pandemic on young people living with HIV in Lesotho: a qualitative study. BMJ Public Health, 2(1), Article e000414. https://doi.org/10.1136/bmjph-2023-000414

Introduction: There is a growing body of research evidencing the detrimental impact of the COVID-19 pandemic on the mental health and well-being of young people. This impact may be worse in low-resource settings, especially those in sub-Saharan Afric... Read More about Impact of the COVID-19 pandemic on young people living with HIV in Lesotho: a qualitative study.

The impact of mental health and psychosocial support programmes on children and young people's mental health in the context of humanitarian emergencies in low- and middle-income countries: A systematic review and meta-analysis. (2024)
Journal Article
Bangpan, M., Felix, L., Soliman, F., D'Souza, P., Jieman, A., & Dickson, K. (2024). The impact of mental health and psychosocial support programmes on children and young people's mental health in the context of humanitarian emergencies in low- and middle-income countries: A systematic review and meta-analysis. Global Mental Health, 11, Article e21. https://doi.org/10.1017/gmh.2024.17

Humanitarian emergencies pose a significant global health challenge for children and young people's mental and psychological health. This systematic review investigates the effectiveness of mental health and psychosocial support (MHPSS) programmes de... Read More about The impact of mental health and psychosocial support programmes on children and young people's mental health in the context of humanitarian emergencies in low- and middle-income countries: A systematic review and meta-analysis..

Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka. (2023)
Journal Article
Zavos, H. M. S., Riddleston, L., Jayaweera, K., Dissanayake, L., Jabir, S., Pannala, G., …Rijsdijk, F. V. (in press). Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka. Behavior Genetics, 54, 73–85. https://doi.org/10.1007/s10519-023-10165-8

Low- and middle-income countries (LMICs) globally have undergone rapid urbanisation, and changes in demography and health behaviours. In Sri Lanka, cardio-vascular disease and diabetes are now leading causes of mortality. High prevalence of their ris... Read More about Frequency of Consumption of Food Groups and Cardio-Metabolic Risk Factors: A Genetically Informative Twin Study in Sri Lanka..

A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty (2023)
Journal Article
Hodgson, J. R., Benkowitz, C., Castellani, B. C., Ellison, A., Yassaie, R., Twohig, H., …Fowler-Davis, S. (2023). A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty. Environments, 11(1), Article 4. https://doi.org/10.3390/environments11010004

Environmental and public health research has given considerable attention to the impact of air quality on brain health, with systematic reviews being widespread. No literature review has been conducted for cognitive frailty—a multidimensional syndrom... Read More about A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty.

Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease (2023)
Journal Article
Mayne, K. J., Staplin, N., Keane, D. F., Wanner, C., Brenner, S., Cejka, V., …Herrington, W. G. (2023). Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease. Journal of the American Society of Nephrology, 35(2), 202-215. https://doi.org/10.1681/asn.0000000000000271

BACKGROUND: Chronic kidney disease (CKD) is associated with fluid excess which can be estimated by bioimpedance spectroscopy. We aimed to assess effects of sodium glucose co-transporter 2 inhibition on bioimpedance-derived “Fluid Overload” and adipos... Read More about Effects of Empagliflozin on Fluid Overload, Weight and Blood Pressure in Chronic Kidney Disease.

The association of age at psoriasis onset and HLA-C*06:02 with biologic survival in patients with moderate-to-severe psoriasis: a cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) (2023)
Journal Article
Alabas, O. A., Mason, K. J., Yiu, Z. Z. N., Warren, R. B., Dand, N., Barker, J. N., …Warren, R. B. (2024). The association of age at psoriasis onset and HLA-C*06:02 with biologic survival in patients with moderate-to-severe psoriasis: a cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR). British Journal of Dermatology, 190(5), 689–700. https://doi.org/10.1093/bjd/ljad481

Background
Few studies have used real-world data to investigate the association between biologic therapy survival and age at psoriasis onset or HLA-C*06:02 status in patients with moderate-to-severe psoriasis. The robustness of these studies is limi... Read More about The association of age at psoriasis onset and HLA-C*06:02 with biologic survival in patients with moderate-to-severe psoriasis: a cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).