Skip to main content

Research Repository

Advanced Search

Interplay between patient and centre factors in home therapy uptake: A sequences-of-regressions analysis using linked UK Renal Registry to centre survey data (2025)
Preprint / Working Paper
Potts, J., M Pearse, C., Lambie, M., Fotheringham, J., Hill, H., Coyle, D., Damery, S., Allen, K., Williams, I., J Davies, S., & Solis-Trapala, I. (2025). Interplay between patient and centre factors in home therapy uptake: A sequences-of-regressions analysis using linked UK Renal Registry to centre survey data

Rationale & Objective Disparities in home dialysis therapy (HT) use may stem from the interplay between dialysis centre services and patient characteristics. We analysed how these factors directly and indirectly affect HT uptake in England.

Study... Read More about Interplay between patient and centre factors in home therapy uptake: A sequences-of-regressions analysis using linked UK Renal Registry to centre survey data.

Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “<i>a super weapon to make the whole experience a bit better”</i> (2025)
Preprint / Working Paper
Teasdale, E., Dewar-Haggart, R., Pollet, S., Leydon, G. M., Everitt, H., Cross, N., Atherton, H., Becque, T., Bostock, J., Garfield, K., Herbert, A., Howick, J., Little, P., Mallen, C., Morrison, L., Nuttall, J., Ridd, M. J., Robnson, M. E., Stuart, B., Vennick, J., …Bishop, F. L. (2025). Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “a super weapon to make the whole experience a bit better”

Objectives To examine primary care practitioners’ experiences and use of EMPathicO e-learning to enhance communication of clinical empathy and realistic optimism.

Design Mixed methods evaluation incorporating thematic analysis of qualitative inter... Read More about Mixed methods evaluation of using the ‘EMPathicO’ communication skills e-learning in primary care: “<i>a super weapon to make the whole experience a bit better”</i>.

The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine using a person-centred approach (2025)
Preprint / Working Paper
Bullock, L., Tyler, N., Clark, E. M., Thomas, S., Gidlow, C., Bentley, I., Hawarden, A., Peel, N., Gregson, C. L., Ralston, S. H., Protheroe, J., Lefroy, J., O’Neill, T. W., Mallen, C., Clare, J., & Paskins, Z. (in press). The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine using a person-centred approach

Objectives The improving uptake of Fracture Prevention treatments (iFraP) intervention consists of an osteoporosis decision support tool (DST), clinician skills training, and information resources, to improve shared decision-making (SDM) about, and u... Read More about The Michael Mason Prize: Development and feasibility testing of a complex intervention to improve adherence to fracture prevention medicine using a person-centred approach.

Feasibility and acceptability of implementing the Global Scales for Early Development (GSED) package for children 0–3 years across three countries (2025)
Journal Article
Nizar Merchant, A., Kaur, R., McCray, G., Cavallera, V., Weber, A., Gladstone, M., Janus, M., Nisar, I., Kariger, P., Sazawal, S., Dutta, A., Zhang, Y., Pacifico Mercadante, M., Zongo, A., Schonbeck, Y., Dua, T., Eekhout, I., Tofail, F., Black, M., Baqui, A., …Lancaster, G. (in press). Feasibility and acceptability of implementing the Global Scales for Early Development (GSED) package for children 0–3 years across three countries. Pilot and Feasibility Studies, 11(1), 1-21. https://doi.org/10.1186/s40814-024-01583-4

Background: To assess the neurodevelopment of children under three years, a multinational team of subject matter experts (SMEs) led by the World Health Organization (WHO) developed the Global Scales for Early Development (GSED). The measures include... Read More about Feasibility and acceptability of implementing the Global Scales for Early Development (GSED) package for children 0–3 years across three countries.

Association of air pollution from a landfill site with primary care consultation (2024)
Preprint / Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., Mallen, C. D., Mason, K. J., Wathall, S., & van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.

Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097) (2024)
Preprint / Working Paper
Wynne-Jones, G., Lewis, M., Sowden, G., Madan, I., Walker-Bone, K., Chew-Graham, C., Bromley, K., Jowett, S., Parsons, V., Mansell, G., Cooke, K., Lawton, S., Saunders, B., Pemberton, J., Cooper, C., & Foster, N. Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097)

Objectives To investigate the effectiveness of adding a brief vocational advice intervention to usual care in reducing the number of days absent from work over a period of 6 months in adults given a fit note by their general practice.

Design Multi... Read More about Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097).

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype (2024)
Preprint / Working Paper
Ioannou, S., G Kay, A., P Stone, A., Rand, E., Elberfeld, S., Bolton, W., Larson, T., E Crossland, R., Kehoe, O., A Mentlak, D., Wang, X.-N., MacDonald, C., & Genever, P. Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype

Mesenchymal stromal cells (MSCs) are a promising source of therapeutic extracellular vesicles (EVs), however it is not clear how heterogeneity within a non-clonal MSC population will affect the collective EV pool. Here we used immortalised clonal MSC... Read More about Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype.

Diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records (2024)
Working Paper
Dyer, B., Burton, C., Rathod-Mistry, T., Blagojevic-Bucknall, M., & van der Windt, D. Diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records

Objective Estimate the effect of type 2 diabetes on the development of frozen shoulder and investigate whether the effect is mediated by other metabolic factors. Methods Primary care medical record-based cohort study containing 43,977 patients newly... Read More about Diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records.

Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID) (2024)
Preprint / Working Paper
Hammond, B., Baranskaya, A., Adderley, N., Zemedikun, D., d’Elia, A., Falahee, M., Mallen, C., Insch, E., Singh Chandan, J., Nirantharakumar, K., Snell, K., & Raza, K. Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID)

Background Rheumatoid Arthritis (RA) is a chronic rheumatological condition which causes inflammation of both the joint lining and extra-articular sites. It affects around 1% of the UK population and, if not properly treated, can lead joint damage, d... Read More about Protocol for the development and validation of a Rheumatoid Arthritis PredIction moDel using primary care health records (RAPID).

Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial (2024)
Preprint / Working Paper
Kigozi, J., Hill, J. C., Bromley, K., Lewis, M., Wathall, S., Chudyk, A., Dunn, K. M., Foster, N. E., & Jowett, S. Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial

Background
Risk-based stratified care (SC) has demonstrated cost-effectiveness versus usual primary care for non-specific low back pain. The STarT MSK trial investigated the cost-effectiveness of risk-based stratified care versus non-stratified usua... Read More about Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial.

Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh (2024)
Preprint / Working Paper
Nayeem Hasan, M., Rahman, M., Fahim Uddin, M., Ali Akbar Ashrafi, S., Rahman, K. M., Kumar Paul, K., Rahman Sarker, M. F., Haque, F., Sharma, A., Papakonstantinou, D., Paudyal, P., Asaduzzaman, M., Zumla, A., & Haider, N. Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh

In 2023, Bangladesh experienced its largest and deadliest outbreak of Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. We aimed to characterize the geographical transmission of the DENV in Bangladesh. From 1 Jan – 31... Read More about Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh.

Automating incidence and prevalence analysis in open cohorts (2024)
Preprint / Working Paper
Cockburn, N., Hammond, B., Ghani, I., Cusworth, S., Acharya, A., Gokhale, K., Thayakaran, R., Crowe, F., Minhas, S., Parry-Smith, W., Taylor, B., Nirantharakumar, K., & Singh Chandan, J. Automating incidence and prevalence analysis in open cohorts

Motivation

Increasingly vast quantities of data support improvement and research in public health, and growth is especially seen in administrative data such as that collected in electronic health records. Patients enter and exit these typically o... Read More about Automating incidence and prevalence analysis in open cohorts.

The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses (2024)
Preprint / Working Paper
Gibson, J., Kontopantelis, E., Sutton, M., Boaz, A., Little, P., Mallen, C., McManus, R., Park, S., Usher-Smith, J., & Bower, P. (2024). The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses

Introduction
Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that... Read More about The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses.

Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics (2024)
Journal Article
Nayeem Hasan, M., Khalil, I., Baker Chowdhury, M. A., Rahman, M., Asaduzzaman, M., Billah, M., Anjuman Banu, L., Alam, M., Ahsan, A., Traore, T., Jamal Uddin, M., Galizi, R., Russo, I., Zumla, A., & Haider, N. (in press). Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics. GreSIS - Greater South Information System, https://doi.org/10.60692/x6t6v-mbt18

The objectives of this study were to compare dengue virus (DENV) cases, deaths, case-fatality ratio [CFR], and meteorological parameters between the first and the recent decades of this century (2000-2010 vs. 2011-2022) and to describe the trends, se... Read More about Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics.

Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial (2024)
Preprint / Working Paper
Ryde, E., Hollingsworth, K., Littlewood, E., Atha, L., Bailey, D., Baker, H., Bosanquet, K., Shearsmith, L., Chew-Graham, C. A., McMillan, D., Baird, K., Coventry, P., Crosland, S., Fairhurst, C., Wang, H.-I., Burke, L., Heeley, J., Hewitt, C., Clegg, A., Gentry, T., …Ekers, D. Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial

Introduction Older adults (65 years or over) and those with long-term health conditions (LTCs), represent a ‘high risk’ group for depression, with a risk two-to-three times the general population. This can lead to poorer quality of life and be costly... Read More about Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial.

A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA) (2023)
Other
Singh, B., Kumari-Dewat, N., Ryder, A., Klaire, V., Bennion, G., Jennens, H., Matthews, D., Rayner, S., Ritzenthaler, B., Shears, J., Ahmed, K., Sidhu, M., Viswanath, A., Warren, K., & Parry, E. (2023). A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA)

Objective To determine the accuracy of a clinical data algorithm allocated end-of-life prognosis amongst hospital inpatients.

Method The model allocated a predicted Gold Standard Framework end-of-life prognosis to all acute medical patients admitt... Read More about A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA).

VESCA’s variable precision: Determining the accuracy of adjustment for examiner differences in distributed OSCEs (2023)
Preprint / Working Paper
Yeates, P., & McCray, G. (2023). VESCA’s variable precision: Determining the accuracy of adjustment for examiner differences in distributed OSCEs

Introduction: Ensuring examiner equivalence across assessment locations is a priority within distributed Objective Structured Clinical Exams (OSCEs) but is challenging due to lack of overlap in performances judged by different groups of examiners. Ye... Read More about VESCA’s variable precision: Determining the accuracy of adjustment for examiner differences in distributed OSCEs.

Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis (2023)
Preprint / Working Paper
Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., Somayajula, G., Van der Windt, D., Welsh, V., & Burton, C. Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis

Background Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The nature of this in CYP is unclear, as are the sequalae of acute COVID-19. We aimed to systematically synthesise evidence... Read More about Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis.