Estimating disease burden using national linked electronic health records: a study using an English population-based cohort. (2023)
Journal Article
Aldridge, R. W., Evans, H. E., Yavlinsky, A., Moayyeri, A., Bhaskaran, K., Mathur, R., Jordan, K. P., Croft, P., Denaxas, S., Shah, A. D., Blackburn, R. M., Moller, H., Ng, E. S., Hughes, A., Fox, S., Flowers, J., Schmidt, J., Hayward, A., Gilbert, R., Smeeth, L., & Hemingway, H. (2023). Estimating disease burden using national linked electronic health records: a study using an English population-based cohort. Wellcome Open Research, 8, 262. https://doi.org/10.12688/wellcomeopenres.19470.2

Background: Electronic health records (EHRs) have the potential to be used to produce detailed disease burden estimates. In this study we created disease estimates using national EHR for three high burden conditions, compared estimates between linked... Read More about Estimating disease burden using national linked electronic health records: a study using an English population-based cohort..

The establishment, maintenance, and adaptation of high- and low-impact chronic pain: a framework for biopsychosocial pain research. (2023)
Journal Article
Eccleston, C., Begley, E., Birkinshaw, H., Choy, E., Crombez, G., Fisher, E., Gibby, A., Gooberman-Hill, R., Grieve, S., Guest, A., Jordan, A., Lilywhite, A., Macfarlane, G. J., McCabe, C., McBeth, J., Pickering, A. E., Pincus, T., Sallis, H. M., Stone, S., Van der Windt, D., …Keogh, E. (in press). The establishment, maintenance, and adaptation of high- and low-impact chronic pain: a framework for biopsychosocial pain research. PAIN, 164(10), 2143-2147. https://doi.org/10.1097/j.pain.0000000000002951

An empirical investigation of intuitions about uptake (2023)
Journal Article
Fisher, S. A., A. Fisher, S., Francis, K. B., B. Francis, K., & Townsend, L. (2023). An empirical investigation of intuitions about uptake. Inquiry, 1-33. https://doi.org/10.1080/0020174X.2023.2220359

Since Austin’s introduction of the locutionary-illocutionary-perlocutionary distinction, it has been a matter of debate within speech act theory whether illocutionary acts like promising, warning, refusing and telling require audience ‘uptake’ in ord... Read More about An empirical investigation of intuitions about uptake.

Illuminating the brain: Revealing brain biochemistry with synchrotron X-ray spectromicroscopy (2023)
Journal Article
Everett, J., Brooks, J., Lermyte, F., Tjhin, V. T., Hands-Portman, I., Hill, E., Collingwood, J. F., & Telling, N. D. (2023). Illuminating the brain: Revealing brain biochemistry with synchrotron X-ray spectromicroscopy. Journal of Electron Spectroscopy and Related Phenomena, 266, Article ARTN 147355. https://doi.org/10.1016/j.elspec.2023.147355

The synchrotron x-ray spectromicroscopy technique Scanning Transmission X-ray Microscopy (STXM) offers a powerful means to examine the underlying biochemistry of biological systems, owing to its combined chemical sensitivity and nanoscale spatial res... Read More about Illuminating the brain: Revealing brain biochemistry with synchrotron X-ray spectromicroscopy.

Refined parameters of the HD 22946 planetary system and the true orbital period of planet d (2023)
Journal Article
Garai, Z., Osborn, H. P., Gandolfi, D., Brandeker, A., Sousa, S. G., Lendl, M., Bekkelien, A., Broeg, C., Cameron, A. C., Egger, J. A., Hooton, M. J., Alibert, Y., Delrez, L., Fossati, L., Salmon, S., Wilson, T. G., Bonfanti, A., Tuson, A., Ulmer-Moll, S., Serrano, L. M., …Walton, N. (2023). Refined parameters of the HD 22946 planetary system and the true orbital period of planet d. Astronomy & Astrophysics, 674, Article A44. https://doi.org/10.1051/0004-6361/202345943

Context. Multi-planet systems are important sources of information regarding the evolution of planets. However, the long-period planets in these systems often escape detection. These objects in particular may retain more of their primordial character... Read More about Refined parameters of the HD 22946 planetary system and the true orbital period of planet d.

Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort. (2023)
Journal Article
Chew, N. W. S., Chong, B., Kuo, S. M., Jayabaskaran, J., Cai, M., Zheng, H., Goh, R., Kong, G., Chin, Y. H., Imran, S. S., Liang, M., Lim, P., Yong, T. H., Liew, B. W., Chia, P. L., Ho, H. H., Foo, D., Khoo, D., Huang, Z., Chua, T., …Chan, M. Y. (2023). Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort. The Lancet Regional Health - Western Pacific, 37, Article 100803. https://doi.org/10.1016/j.lanwpc.2023.100803

Understanding the trajectories of metabolic risk factors for acute myocardial infarction (AMI) is necessary for healthcare policymaking. We estimated future projections of the incidence of metabolic diseases in a multi-ethnic population with AMI. The... Read More about Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort..

Chemical Diversification of Carbocyclic Fluorinated Pyrimidine Nucleosides: Introducing 2'-Arabino Analogues and Ring Unsaturation (2023)
Journal Article
Benckendorff, C. M. M., Hawes, C. S., Smith, M., & Miller, G. J. (2023). Chemical Diversification of Carbocyclic Fluorinated Pyrimidine Nucleosides: Introducing 2'-Arabino Analogues and Ring Unsaturation. SYNLETT, 35(06), 659-664. https://doi.org/10.1055/a-2079-9310

Analogues of the canonical nucleosides have a longstanding presence and proven capability within medicinal chemistry and drug-discovery research. Herein, we report chemical diversification of carbocyclic pyrimidine nucleosides containing CF2 and CHF... Read More about Chemical Diversification of Carbocyclic Fluorinated Pyrimidine Nucleosides: Introducing 2'-Arabino Analogues and Ring Unsaturation.

Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides. (2023)
Journal Article
Porter, J., Parisi, D., Miller, T., Cheallaigh, A. N., & Miller, G. J. (2023). Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides. Carbohydrate Research, 530, Article 108854. https://doi.org/10.1016/j.carres.2023.108854

Amphiphilic glycoconjugates offer an important prospect for development as chemical biology tools and biosurfactants. The chemical synthesis of such materials is required to expedite such prospect, compounded by the example of oleyl glycosides. Herei... Read More about Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides..

Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset) (2023)
Journal Article
Terry, J., Ross, R. M., Nagy, T., Salgado, M., Garrido-Vásquez, P., Sarfo, J. O., Cooper, S., Buttner, A. C., Lima, T. J. S., Öztürk, İ., Akay, N., Santos, F. H., Artemenko, C., Copping, L. T., Elsherif, M. M., Milovanović, I., Cribbie, R. A., Drushlyak, M. G., Swainston, K., Shou, Y., …Field, A. P. (in press). Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset). Journal of Open Psychology Data, 11(1), Article 8. https://doi.org/10.5334/jopd.80

This large, international dataset contains survey responses from N = 12,570 students from 100 universities in 35 countries, collected in 21 languages. We measured anxieties (statistics, mathematics, test, trait, social interaction, performance, creat... Read More about Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset).

Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release (2023)
Journal Article
Davies, R., Allen, S., Mennan, C., Platt, M., Wright, K., & Kehoe, O. (2023). Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release. International Journal of Molecular Sciences, 24(11), 9242. https://doi.org/10.3390/ijms24119242

The immunomodulatory properties of MSCs can be recreated using their extracellular vesicles (EVs). Yet, the true capabilities of the MSC EVs cannot be distinguished from contaminating bovine EVs and protein derived from supplemental foetal bovine ser... Read More about Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release.

Recognition, remember-know, and confidence judgments: no evidence of cross-contamination here! (2023)
Journal Article
Williams, H. L., Bodner, G. E., & Lindsay, D. S. (2023). Recognition, remember-know, and confidence judgments: no evidence of cross-contamination here!. Memory, 31(7), 905-917. https://doi.org/10.1080/09658211.2023.2207804

We report three experiments designed to reveal the mechanisms that underlie subjective experiences of recognition by examining effects of how those experiences are measured. Prior research has explored the potential influences of collecting metacogni... Read More about Recognition, remember-know, and confidence judgments: no evidence of cross-contamination here!.

Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. (2023)
Other
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., Kyrou, K., Game, L., Nolan, T., & Galizi, R. (2023). Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome..

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence (2023)
Journal Article
Jangir, P., Ogunlana, L., Szili, P., Czikkely, M., P Shaw, L., Stevens, E. J., Yu, Y., Yang, Q., Wang, Y., Pal, C., R Walsh, T., & R MacLean, C. (2023). The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence. eLife, 12, 1-22. https://doi.org/10.7554/elife.84395

Antimicrobial peptides (AMPs) offer a promising solution to the antibiotic resistance crisis. However, an unresolved serious concern is that the evolution of resistance to therapeutic AMPs may generate cross-resistance to host AMPs, compromising a co... Read More about The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence.

Mapping the distribution of OB stars and associations in Auriga (2023)
Journal Article
Quintana, A. L., Wright, N. J., & Jeffries, R. D. (2023). Mapping the distribution of OB stars and associations in Auriga. Monthly Notices of the Royal Astronomical Society, 522(2), 3124-3137. https://doi.org/10.1093/mnras/stad1160

OB associations are important probes of recent star formation and Galactic structure. In this study, we focus on the Auriga constellation, an important region of star formation due to its numerous young stars, star-forming regions, and open clusters.... Read More about Mapping the distribution of OB stars and associations in Auriga.

Rural businesses and levelling up: A rural-urban analysis of business innovation and exporting in England's north and midlands (2023)
Journal Article
Tiwasing, P., Gorton, M., Phillipson, J., & Maioli, S. (2023). Rural businesses and levelling up: A rural-urban analysis of business innovation and exporting in England's north and midlands. Journal of Rural Studies, 100, Article ARTN 103007. https://doi.org/10.1016/j.jrurstud.2023.103007

In the face of persistent and widening regional imbalances in economic and social outcomes, the UK Government seeks to ‘level up’ less prosperous communities, reigniting debates on the relationships between geography and business innovation. A key qu... Read More about Rural businesses and levelling up: A rural-urban analysis of business innovation and exporting in England's north and midlands.

Turbulence and nuclear reactions in 3D hydrodynamics simulations of massive stars (2023)
Journal Article
Rizzuti, F., Hirschi, R., Georgy, C., Arnett, D., Meakin, C., & Murphy, A. (2023). Turbulence and nuclear reactions in 3D hydrodynamics simulations of massive stars. EPJ Web of Conferences, 279, 05001. https://doi.org/10.1051/epjconf/202327905001

Our knowledge of massive star evolution and nucleosynthesis is limited by uncertainties related to multi-dimensional processes taking place in stellar interiors. Recently, theoretical works have started to improve 1D stellar evolution codes through t... Read More about Turbulence and nuclear reactions in 3D hydrodynamics simulations of massive stars.

The wide-field, multiplexed, spectroscopic facility WEAVE: Survey design, overview, and simulated implementation (2023)
Journal Article
Jin, S., Trager, S. C., Dalton, G. B., Aguerri, J. A. L., Drew, J. E., Falcón-Barroso, J., Gänsicke, B. T., Hill, V., Iovino, A., Pieri, M. M., Poggianti, B. M., Smith, D. J. B., Vallenari, A., Abrams, D. C., Aguado, D. S., Antoja, T., Aragón-Salamanca, A., Ascasibar, Y., Babusiaux, C., Balcells, M., …Zurita, C. (2024). The wide-field, multiplexed, spectroscopic facility WEAVE: Survey design, overview, and simulated implementation. Monthly Notices of the Royal Astronomical Society, 530(3), 2688-2730. https://doi.org/10.1093/mnras/stad557

WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, saw first light in late 2022. WEAVE comprises a new 2-deg field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre pos... Read More about The wide-field, multiplexed, spectroscopic facility WEAVE: Survey design, overview, and simulated implementation.

Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer (2023)
Journal Article
Mamas, M. A., Raisi-Estabragh, Z., Cooper, J., McCracken, C., Crosbie, E. J., Walter, F. M., Manisty, C. H., Robson, J., Harvey, N. C., Neubauer, S., & Petersen, S. E. (2023). Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer. Heart, heartjnl-2022-321888. https://doi.org/10.1136/heartjnl-2022-321888

Objectives: To evaluate incident cardiovascular outcomes and imaging phenotypes in UK Biobank participants with previous cancer. Methods: Cancer and cardiovascular disease (CVD) diagnoses were ascertained using health record linkage. Participants wit... Read More about Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer.

Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer (2023)
Journal Article
Bouzy, P., Lyburn, I. D., Pinder, S. E., Scott, R., Mansfield, J., Moger, J., Greenwood, C., Bouybayoune, I., Cornford, E., Rogers, K., & Stone, N. (in press). Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer. Analytical Methods, 15(13), 1620-1630. https://doi.org/10.1039/d2ay01197b

Microcalcifications play an important role in cancer detection. They are evaluated by their radiological and histological characteristics but it is challenging to find a link between their morphology, their composition and the nature of a specific ty... Read More about Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer.

“It was really poor prior to the pandemic. It got really bad after”: A qualitative study of the impact of COVID-19 on prison healthcare in England (2023)
Journal Article
Wainwright, L., Senker, S., Canvin, K., & Sheard, L. (2023). “It was really poor prior to the pandemic. It got really bad after”: A qualitative study of the impact of COVID-19 on prison healthcare in England. Health and Justice, 11, Article 6. https://doi.org/10.1186/s40352-023-00212-1

Background
The impact of COVID-19 has been exceptional, particularly on the National Health Service which has juggled COVID affected patients alongside related staff shortages and the existing (and growing) health needs of the population. In prisons... Read More about “It was really poor prior to the pandemic. It got really bad after”: A qualitative study of the impact of COVID-19 on prison healthcare in England.