Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial (2024)
Preprint / Working Paper
Kigozi, J., Hill, J. C., Bromley, K., Lewis, M., Wathall, S., Chudyk, A., Dunn, K. M., Foster, N. E., & Jowett, S. Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial

Background
Risk-based stratified care (SC) has demonstrated cost-effectiveness versus usual primary care for non-specific low back pain. The STarT MSK trial investigated the cost-effectiveness of risk-based stratified care versus non-stratified usua... Read More about Cost-utility analysis of risk-based stratified primary care for common musculoskeletal pain presentations: a cluster-randomised, controlled trial.

Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh (2024)
Preprint / Working Paper
Nayeem Hasan, M., Rahman, M., Fahim Uddin, M., Ali Akbar Ashrafi, S., Rahman, K. M., Kumar Paul, K., Rahman Sarker, M. F., Haque, F., Sharma, A., Papakonstantinou, D., Paudyal, P., Asaduzzaman, M., Zumla, A., & Haider, N. Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh

In 2023, Bangladesh experienced its largest and deadliest outbreak of Dengue virus (DENV), reporting the highest-ever recorded annual cases and deaths. We aimed to characterize the geographical transmission of the DENV in Bangladesh. From 1 Jan – 31... Read More about Shifting Geographical Transmission Patterns: Characterizing the 2023 Fatal Dengue Outbreak in Bangladesh.

Automating incidence and prevalence analysis in open cohorts (2024)
Preprint / Working Paper
Cockburn, N., Hammond, B., Ghani, I., Cusworth, S., Acharya, A., Gokhale, K., Thayakaran, R., Crowe, F., Minhas, S., Parry-Smith, W., Taylor, B., Nirantharakumar, K., & Singh Chandan, J. Automating incidence and prevalence analysis in open cohorts

Motivation

Increasingly vast quantities of data support improvement and research in public health, and growth is especially seen in administrative data such as that collected in electronic health records. Patients enter and exit these typically o... Read More about Automating incidence and prevalence analysis in open cohorts.

The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses (2024)
Preprint / Working Paper
Gibson, J., Kontopantelis, E., Sutton, M., Boaz, A., Little, P., Mallen, C., McManus, R., Park, S., Usher-Smith, J., & Bower, P. (2024). The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses

Introduction
Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that... Read More about The relationship between research activity and the performance of English general practices: cross sectional and longitudinal analyses.

Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics (2024)
Journal Article
Nayeem Hasan, M., Khalil, I., Baker Chowdhury, M. A., Rahman, M., Asaduzzaman, M., Billah, M., Anjuman Banu, L., Alam, M., Ahsan, A., Traore, T., Jamal Uddin, M., Galizi, R., Russo, I., Zumla, A., & Haider, N. (in press). Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics. GreSIS - Greater South Information System, https://doi.org/10.60692/x6t6v-mbt18

The objectives of this study were to compare dengue virus (DENV) cases, deaths, case-fatality ratio [CFR], and meteorological parameters between the first and the recent decades of this century (2000-2010 vs. 2011-2022) and to describe the trends, se... Read More about Two decades of endemic dengue in Bangladesh (2000–2022): trends, seasonality, and impact of temperature and rainfall patterns on transmission dynamics.

Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial (2024)
Preprint / Working Paper
Ryde, E., Hollingsworth, K., Littlewood, E., Atha, L., Bailey, D., Baker, H., Bosanquet, K., Shearsmith, L., Chew-Graham, C. A., McMillan, D., Baird, K., Coventry, P., Crosland, S., Fairhurst, C., Wang, H.-I., Burke, L., Heeley, J., Hewitt, C., Clegg, A., Gentry, T., …Ekers, D. Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial

Introduction Older adults (65 years or over) and those with long-term health conditions (LTCs), represent a ‘high risk’ group for depression, with a risk two-to-three times the general population. This can lead to poorer quality of life and be costly... Read More about Multimorbidity in Older Adults with Depression Study (MODS) (Behavioural Activation to improve physical and mental functioning among older people with multiple long-term conditions): Protocol for a fully powered randomised controlled trial.

A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA) (2023)
Other
Singh, B., Kumari-Dewat, N., Ryder, A., Klaire, V., Bennion, G., Jennens, H., Matthews, D., Rayner, S., Ritzenthaler, B., Shears, J., Ahmed, K., Sidhu, M., Viswanath, A., Warren, K., & Parry, E. (2023). A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA)

Objective To determine the accuracy of a clinical data algorithm allocated end-of-life prognosis amongst hospital inpatients.

Method The model allocated a predicted Gold Standard Framework end-of-life prognosis to all acute medical patients admitt... Read More about A prediction algorithm to improve the accuracy of the Gold Standard Framework Surprise Question end-of-life prognostic categories in an acute hospital admission cohort-controlled study. The Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA).

Achieving zero by 30 in Bangladesh through a One Health approach (2023)
Preprint / Working Paper
Ghosh, S., Hasan, M., Nath, N., Haider, N., Higgins Jones, D., Islam, M., Rahaman, M. M., Mursalin, H., Mahmud, N., Kamruzzaman, M., Rabby, M. F., Kar, S., Ullah, S. M., Rashed Shah, M., Jahan, A., Sohel Rana, M., Chowdhury, S., Uddin, M. J., Sunil, T., Ahmed, B.-N., …Islam, M. N. Achieving zero by 30 in Bangladesh through a One Health approach

Background: Bangladesh is making progress toward achieving zero human dog-mediated rabies deaths by 2030, a global goal set in 2015.

Methods: Drawing from multiple datasets, including patient immunization record books and mass dog vaccination (MD... Read More about Achieving zero by 30 in Bangladesh through a One Health approach.

The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner (2023)
Preprint / Working Paper
Shephard, M. T., Merkhan, M. M., Dale, T. P., & Forsyth, N. R. (2023). The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner

Background
Chronic disease states can share inflammation as an underlying pathology. Macrophages are associated with chronic inflammation; in general, M1 phenotype macrophage activity inhibits cell proliferation and causes tissue damage whilst M2 ma... Read More about The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner.

Decellularisation and characterisation of porcine pleura for lung tissue engineering (2023)
Journal Article
Vikranth, T., Dale, T., & Forsyth, N. R. (in press). Decellularisation and characterisation of porcine pleura for lung tissue engineering. bioRxiv, https://doi.org/10.1101/2023.06.20.545830

Decellularisation offers a broad range of biomimetic scaffolds of allogeneic and xenogeneic origins, exhibiting innate tissue-specific characteristics. We explored a physico-chemical method for decellularising porcine pleural membranes (PPM) as poten... Read More about Decellularisation and characterisation of porcine pleura for lung tissue engineering.

VESCA’s variable precision: Determining the accuracy of adjustment for examiner differences in distributed OSCEs (2023)
Preprint / Working Paper
Yeates, P., & McCray, G. (2023). VESCA’s variable precision: Determining the accuracy of adjustment for examiner differences in distributed OSCEs

Introduction: Ensuring examiner equivalence across assessment locations is a priority within distributed Objective Structured Clinical Exams (OSCEs) but is challenging due to lack of overlap in performances judged by different groups of examiners. Ye... Read More about VESCA’s variable precision: Determining the accuracy of adjustment for examiner differences in distributed OSCEs.

Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis (2023)
Preprint / Working Paper
Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., Somayajula, G., Van der Windt, D., Welsh, V., & Burton, C. Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis

Background Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The nature of this in CYP is unclear, as are the sequalae of acute COVID-19. We aimed to systematically synthesise evidence... Read More about Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis.

Eliciting and prioritising determinants of improved care in Multiple Long Term Health Conditions (MLTC): A modified online Delphi study (2023)
Other
Simpson, G., Stuart, B., Hijryana, M., Kwame Akyea, R., Stokes, J., Gibson, J., Jones, K., Morrison, L., Santer, M., Boniface, M., Zlatev, Z., Farmer, A., & Dambha-Miller, H. (2023). Eliciting and prioritising determinants of improved care in Multiple Long Term Health Conditions (MLTC): A modified online Delphi study

Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes (2023)
Preprint / Working Paper
Hegde, S., Brettell, L. E., Quek, S., Etebari, K., Saldaña, M. A., Asgari, S., Coon, K. L., Heinz, E., & Hughes, G. L. Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes

The mosquito microbiome is critical for host development and plays a major role in many aspects of mosquito biology. While the microbiome is commonly dominated by a small number of genera, there is considerable variation in composition among mosquito... Read More about Aedes aegyptigut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes.

The Equator Project (2023)
Journal Article
Dowey, N., Giles, S., Jackson, C., Williams, R., Fernando, B., Lawrence, A., Raji, M., Barclay, J., Brotherson, L., Childs, E., Houghton, J., Khatwa, A., Mills, K., Newton, A., Rockey, F., Rogers, S., & Souch, C. (2023). The Equator Project. Earth ArXiv, https://doi.org/10.31223/x5793t

Geopolitical Uncertainty and Banking Risk: International Evidence (2023)
Other
Banna, H., Alam, A., Alam, A. W., & Chen, X. H. (2023). Geopolitical Uncertainty and Banking Risk: International Evidence

We study the impact of geopolitical uncertainty on banking risk. Using a large sample of 21,618 unique banks over a period from 2010 to 2021, our results reveal that geopolitical risk (GPR) significantly increases (erodes) banking risk (stability). T... Read More about Geopolitical Uncertainty and Banking Risk: International Evidence.

Feasibility of linking markers of dementia-related health in primary care medical records to cognitive function assessed in a specialist dementia service (2022)
Other
Marshall, M., Campbell, P., Bailey, J., Chew-Graham, C. A., Croft, P., Frisher, M., Hayward, R., Negi, R., Rathod-Mistry, T., Singh, S., Robinson, L., Sumathipala, A., Thein, N., Walters, K., Weich, S., & Jordan, K. P. (2022). Feasibility of linking markers of dementia-related health in primary care medical records to cognitive function assessed in a specialist dementia service

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence (2022)
Journal Article
Mallikarjun, V., Dobre, O., Jackson, M., Kidd, M., Llewellyn, J., Gilbert, H., Richardson, S., & Swift, J. (2022). Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence. arXiv,

ABSTRACT Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche exp... Read More about Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence.

Risk-based stratified primary care for common musculoskeletal pain presentations: qualitative findings from the STarT MSK cluster randomised controlled trial (2022)
Other
Saunders, B., Chudyk, A., Protheroe, J., Cooper, V., Bartlam, B., Birkinshaw, H., Foster, N. E., & Hill, J. C. (2022). Risk-based stratified primary care for common musculoskeletal pain presentations: qualitative findings from the STarT MSK cluster randomised controlled trial

Dark Side of Online Brand Communities: A Scoping Review of the Literature (2022)
Working Paper
Behl, A., & Bhutani, C. Dark Side of Online Brand Communities: A Scoping Review of the Literature

Online brand communities are a double-edged sword; providing marketing managers with numerous opportunities to engage with their customers as well as pose serious threats that arise from online consumer empowerment. However, scholars seem to review o... Read More about Dark Side of Online Brand Communities: A Scoping Review of the Literature.