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Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome (2024)
Journal Article
Tierney, L., Kuiper, J. H., Roberts, S., Snow, M., Williams, M., Harrington, M. B., …Wright, K. T. (in press). Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12433

Purpose
To investigate patient demographic, injury and surgery/treatment-associated factors that can influence the patient-reported outcome (Lysholm score), following autologous chondrocyte implantation (ACI) in a large, ‘real-world’, nonuniform, pr... Read More about Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome.

Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra (2024)
Journal Article
Brooks, J., Everett, J., Hill, E., Billimoria, K., Morris, C. M., Sadler, P. J., …Collingwood, J. F. (in press). Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra. Communications Biology, 7(1), Article 1024. https://doi.org/10.1038/s42003-024-06636-1

Neuromelanin-pigmented neurons of the substantia nigra are selectively lost during the progression of Parkinson’s disease. These neurons accumulate iron in the disease state, and iron-mediated neuron damage is implicated in cell death. Animal models... Read More about Nanoscale synchrotron x-ray analysis of intranuclear iron in melanised neurons of Parkinson’s substantia nigra.

Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa (2024)
Journal Article
Li, X., Cheng, J., Han, H., Kirk, W. D., O’Brien, M., Wang, L., …Lu, Y. (in press). Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa. Journal of Chemical Ecology, https://doi.org/10.1007/s10886-024-01532-8

Odontothrips loti (Haliday) (Thysanoptera: Thripidae) is one of the most serious pests on alfalfa, causing direct damage by feeding and indirect damage by transmitting plant viruses. This damage causes significant loss in alfalfa production. Semioche... Read More about Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa.

New Wolf–Rayet wind yields and nucleosynthesis of Helium stars (2024)
Journal Article
Higgins, E. R., Vink, J. S., Hirschi, R., Laird, A. M., & Sander, A. A. C. (2024). New Wolf–Rayet wind yields and nucleosynthesis of Helium stars. Monthly Notices of the Royal Astronomical Society, 533(1), 1095-1110. https://doi.org/10.1093/mnras/stae1853

Strong metallicity-dependent winds dominate the evolution of core He-burning, classical Wolf–Rayet (cWR) stars, which eject both H and He-fusion products such as $^{14}$N, $^{12}$C, $^{16}$O, $^{19}$F, $^{22}$Ne, and $^{23}$Na during their evolution.... Read More about New Wolf–Rayet wind yields and nucleosynthesis of Helium stars.

Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT) (2024)
Journal Article
Farooq, S., Hattle, M., Kingstone, T., Ajnakina, O., Dazzan, P., Demjaha, A., …Riley, R. D. (2024). Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT). British Journal of Psychiatry, 1-10. https://doi.org/10.1192/bjp.2024.101

Background
A clinical tool to estimate the risk of treatment-resistant schizophrenia (TRS) in people with first-episode psychosis (FEP) would inform early detection of TRS and overcome the delay of up to 5 years in starting TRS medication.

Aims... Read More about Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT).

Modelling take-off moment arms in an ornithocheiraean pterosaur (2024)
Journal Article
Griffin, B. W., Martin-Silverstone, E., Pêgas, R. V., Meilak, E. A., Costa, F. R., Palmer, C., & Rayfield, E. J. (in press). Modelling take-off moment arms in an ornithocheiraean pterosaur. PeerJ, 12, Article e17678. https://doi.org/10.7717/peerj.17678

Take-off is a vital part of powered flight which likely constrains the size of birds, yet extinct pterosaurs are known to have reached far larger sizes. Three different hypothesised take-off motions (bipedal burst launching, bipedal countermotion lau... Read More about Modelling take-off moment arms in an ornithocheiraean pterosaur.

Characterization of the δ Scuti eclipsing binary KIC 4851217 and its tertiary companion as well as detection of tidally tilted pulsations (2024)
Journal Article
Jennings, Z., Southworth, J., Rappaport, S. A., Borkovits, T., Handler, G., & Kurtz, D. W. (in press). Characterization of the δ Scuti eclipsing binary KIC 4851217 and its tertiary companion as well as detection of tidally tilted pulsations. Monthly Notices of the Royal Astronomical Society, Article stae1879. https://doi.org/10.1093/mnras/stae1879

Stellar theory enables us to understand the properties of stars at different stages of their evolution, and contributes to other fields of astrophysics such as galactic and exoplanet studies. Assessing the accuracy of stellar theories necessitates hi... Read More about Characterization of the δ Scuti eclipsing binary KIC 4851217 and its tertiary companion as well as detection of tidally tilted pulsations.

Developing a Consensus Statement to Target Oral Health Inequalities in People With Severe Mental Illness (2024)
Journal Article
Mishu, M. P., Aggarwal, V., Shiers, D., Peckham, E., Johnston, G., Joury, E., …Palmier‐Claus, J. (2024). Developing a Consensus Statement to Target Oral Health Inequalities in People With Severe Mental Illness. Health Expectations, 27(4), Article e14163. https://doi.org/10.1111/hex.14163

Introduction: Oral diseases are more prevalent in people with severe mental illness (SMI) compared to those without mental illnees. A greater focus on oral health is needed to reverse unacceptable but often neglected oral health inequality in people... Read More about Developing a Consensus Statement to Target Oral Health Inequalities in People With Severe Mental Illness.

TOI–757 b: an eccentric transiting mini–Neptune on a 17.5–d orbit (2024)
Journal Article
Alqasim, A., Grieves, N., Rosário, N. M., Gandolfi, D., Livingston, J. H., Sousa, S., …Yee, S. W. (2024). TOI–757 b: an eccentric transiting mini–Neptune on a 17.5–d orbit. Monthly Notices of the Royal Astronomical Society, 533(1), 1-26. https://doi.org/10.1093/mnras/stae1767

We report the spectroscopic confirmation and fundamental properties of TOI$-$757 b, a mini$-$Neptune on a 17.5$-$d orbit transiting a bright star ($V\, =\, 9.7$ mag) discovered by the TESS mission. We acquired high$-$precision radial velocity measure... Read More about TOI–757 b: an eccentric transiting mini–Neptune on a 17.5–d orbit.

Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water (2024)
Journal Article
Wahart, A. J. C., Beardmore, L. N. D., Field, R. A., Cosgrove, S. C., & Miller, G. J. (in press). Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water. Organic Letters, 26(31), 6642-6646. https://doi.org/10.1021/acs.orglett.4c02201

We explore biocatalytic aldehyde generation under aqueous conditions, concomitantly delivering access to a one-pot Wittig reaction using stabilized phosphoranes and granting diverse alkene products. Using a recombinant choline oxidase mutant, we firs... Read More about Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water.

Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation (2024)
Journal Article
Wootton, H. S., Berry, S. S., Ferguson, E. L., Mahon, C. S., & Miller, G. J. (in press). Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation. European Journal of Organic Chemistry, Article e202400587. https://doi.org/10.1002/ejoc.202400587

A divergent synthetic route to chondroitin sulfate (CS) disaccharide precursors, including rarer subtypes such as CS‐D, has been developed. From common intermediates, a series of thioglycoside D‐glucosyl donors and 4,6‐O‐benzylidene protected D‐galac... Read More about Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation.

The Gaia-ESO Survey: 3D dynamics of young groups and clusters from GES and Gaia EDR3 (2024)
Journal Article
Wright, N. J., Jeffries, R. D., Jackson, R. J., Sacco, G. G., Arnold, B., Franciosini, E., …Worley, C. C. (2024). The Gaia-ESO Survey: 3D dynamics of young groups and clusters from GES and Gaia EDR3. Monthly Notices of the Royal Astronomical Society, 533(1), 705–728. https://doi.org/10.1093/mnras/stae1806

We present the first large-scale 3D kinematic study of ∼2700 spectroscopically-confirmed young stars (< 20 Myr) in 18 star clusters and OB associations (hereafter groups) from the combination of Gaia astrometry and Gaia-ESO Survey spectroscopy... Read More about The Gaia-ESO Survey: 3D dynamics of young groups and clusters from GES and Gaia EDR3.

CHEOPS in-flight performance: A comprehensive look at the first 3.5 yr of operations (2024)
Journal Article
Fortier, A., Simon, A. E., Broeg, C., Olofsson, G., Deline, A., Wilson, T. G., …Wolter, D. (2024). CHEOPS in-flight performance: A comprehensive look at the first 3.5 yr of operations. Astronomy & Astrophysics, 687, Article A302. https://doi.org/10.1051/0004-6361/202348576

Context. Since the discovery of the first exoplanet almost three decades ago, the number of known exoplanets has increased dramatically. By beginning of the 2000s it was clear that dedicated facilities to advance our studies in this field were needed... Read More about CHEOPS in-flight performance: A comprehensive look at the first 3.5 yr of operations.

PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review (2024)
Journal Article
Kirkby, M., Sabri, A. H. B., Holmes, A., Moss, G. P. J., & Scurr, D. (in press). PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review. Journal of Pharmacy and Pharmacology, 76(10), 1284–1300. https://doi.org/10.1093/jpp/rgae080

Objectives
Poly(amidoamine) dendrimers have been widely investigated as potential nanomaterials that can enhance the skin permeation of topically applied drugs. This article reviews the studies that have used dendrimers as penetration enhancers and... Read More about PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review.

Shell mergers in the late stages of massive star evolution: new insight from 3D hydrodynamic simulations (2024)
Journal Article
Rizzuti, F., Hirschi, R., Varma, V., Arnett, W. D., Georgy, C., Meakin, C., …Rauscher, T. (in press). Shell mergers in the late stages of massive star evolution: new insight from 3D hydrodynamic simulations. Monthly Notices of the Royal Astronomical Society, 533(1), 687-704. https://doi.org/10.1093/mnras/stae1778

One-dimensional (1D) stellar evolution models are widely used across various astrophysical fields, however they are still dominated by important uncertainties that deeply affect their predictive power. Among those, the merging of independent convecti... Read More about Shell mergers in the late stages of massive star evolution: new insight from 3D hydrodynamic simulations.

Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach (2024)
Journal Article
Alpizar-Sosa, E., Zimbres, F. M., Mantilla, B. S., Dickie, E. A., Wei, W., Burle-Caldas, G. A., …Denny, P. W. (in press). Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach. ACS Infectious Diseases, 10(8), 2913-2928. https://doi.org/10.1021/acsinfecdis.4c00284

The lack of effective vaccines and the development of resistance to the current treatments highlight the urgent need for new anti-leishmanials. Sphingolipid metabolism has been proposed as a promising source of Leishmania-specific targets as these li... Read More about Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach.

Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum (2024)
Journal Article
Saha, D., Pramanik, A., Freville, A., Siddiqui, A. A., Pal, U., Banerjee, C., …Bandyopadhyay, U. (2024). Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum. The FEBS Journal, 291(19), 4349-4371. https://doi.org/10.1111/febs.17216

Non-canonical nucleotides, generated as oxidative metabolic by-products, significantly threaten the genome integrity of Plasmodium falciparum and thereby, their survival, owing to their mutagenic effects. PfHAM1, an evolutionarily conserved inosine/x... Read More about Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum.

Substrate-induced strain in molybdenum disulfide grown by aerosol-assisted chemical vapor deposition (2024)
Journal Article
Adams, L. J., Matthews, P. D., Morbec, J. M., & Balakrishnan, N. (in press). Substrate-induced strain in molybdenum disulfide grown by aerosol-assisted chemical vapor deposition. Nanotechnology, 35(39), Article 395602. https://doi.org/10.1088/1361-6528/ad5dc1

Transition metal dichalcogenides have been extensively studied in recent years because of their fascinating optical, electrical, and catalytic properties. However, low-cost, scalable production remains a challenge. Aerosol-assisted chemical vapor dep... Read More about Substrate-induced strain in molybdenum disulfide grown by aerosol-assisted chemical vapor deposition.

Symmetric double-layer capacitor with natural rubber and sodium salt-based solid polymer electrolyte and reduced graphene oxide electrodes (2024)
Journal Article
Perera, K. S., Vidanapathirana, K. P., Adams, L. J., Hawes, C. S., & Balakrishnan, N. (2024). Symmetric double-layer capacitor with natural rubber and sodium salt-based solid polymer electrolyte and reduced graphene oxide electrodes. Journal of Energy Storage, 97, Article 112683. https://doi.org/10.1016/j.est.2024.112683

Solid polymer electrolytes (SPEs) are the key to improving electrochemical devices’ energy density and safety. In recent years, natural polymers have received tremendous attention due to the latest advances in green technology for a sustainable futur... Read More about Symmetric double-layer capacitor with natural rubber and sodium salt-based solid polymer electrolyte and reduced graphene oxide electrodes.