How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England (2024)
Journal Article
Allen, K., Shaw, K. L., Spry, J. L., Dikomitis, L., Coyle, D., Damery, S., …Davies, S. (2024). How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England. BMJ Open, 14(12), https://doi.org/10.1136/bmjopen-2024-085754

Objective: The proportion of people having home dialysis for kidney disease varies considerably by treating centre, socioeconomic deprivation levels in the area and to some extent ethnicity. This study aimed to gain in-depth insights into cultural an... Read More about How does organisational culture facilitate uptake of home dialysis? An ethnographic study of kidney centres in England.

Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two RCTs (2024)
Journal Article
Slob, E. M. A., Vijverberg, S. J. H., Ruffles, T., Noij, L. C. E., Biermann, J., Brouwer, A. F. J., …Maitland‐van der Zee, A. H. (in press). Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two RCTs. Allergy, https://doi.org/10.1111/all.16438

Background: Long‐acting beta2‐agonists (LABA) in combination with inhaled corticosteroids (ICS) are commonly used to treat asthma, however, some children lack response to the addition of LABA. This might be partially due to the presence of the Arg16G... Read More about Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two RCTs.

How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. (2024)
Journal Article
Murphy, A. C., Carroll, W., Gotsell, M., Potter, C., Quint, J. K., & Malone, R. (in press). How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey. BMJ Open Respiratory Research, 11(1), e002579. https://doi.org/10.1136/bmjresp-2024-002579

Inhalers are widely used for the management of asthma and chronic obstructive pulmonary disease. However, there is little knowledge about the extent to which an inhaler is used and when it is disposed of, despite the implications for an individual's... Read More about How do patients determine when their inhaler is empty? Insights from an analysis of returned inhalers and a patient survey..

Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022 (2024)
Journal Article
Ahmed, M., Nofal, A., Shafiq, A., Javaid, H., Ahsan, A., Nadeem, Z. A., …Fonarow, G. C. (in press). Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022. Journal of Diabetes Investigation, https://doi.org/10.1111/jdi.14386

Background: The prevalence of type 2 diabetes (T2D) and obesity are increasing in the United States. However, population‐level data for mortality trends due to T2D and obesity are limited. This study aims to assess these death trends among adults in... Read More about Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022.

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides (2024)
Journal Article
Shen, Z., Simard, M., Brand, D., Andrei, V., Al-Khader, A., Oumlil, F., …Collins-Fekete, C.-A. (in press). A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides. Communications Biology, 7(1), 1674. https://doi.org/10.1038/s42003-024-07398-6

Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incor... Read More about A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.

Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA) (2024)
Journal Article
Yeates, P., & McCray, G. (in press). Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA). BMC Medical Education, 24(1), 1466. https://doi.org/10.1186/s12909-024-06462-3

Introduction: Ensuring examiner equivalence across distributed assessment locations is a priority within distributed Objective Structured Clinical Exams (OSCEs) but is challenging as examiners are typically fully nested within locations (i.e. no over... Read More about Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA).

Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. (2024)
Journal Article
Migliorini, F., Schäfer, L., Pilone, M., Bell, A., Simeone, F., & Maffulli, N. (in press). Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Archives of Orthopaedic and Trauma Surgery, 145(1), 68. https://doi.org/10.1007/s00402-024-05614-w

The present meta-analysis compared the efficacy of intra-articular hyaluronic acid (HA) injections in patients with early to mild knee osteoarthritis (OA) (Kellgren Lawrence I-II) versus other commonly injected biologically active compounds using pat... Read More about Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis..

Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey (2024)
Journal Article
Austin, R., Khair, E., Blakeman, T., Hossain, M. Z., Sowden, E., Chew-Graham, C., …Deaton, C. (2024). Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey. BMJ Open, 14(12), bmjopen-2024-092993. https://doi.org/10.1136/bmjopen-2024-092993

Aim: As heart failure (HF) with preserved ejection fraction (HFpEF) prevalence increases, it remains frequently underdiagnosed and poorly managed. Recent positive pharmacological trials have increased interest in HFpEF but challenges of diagnosis and... Read More about Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey.

Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation (2024)
Journal Article
Carolan, A., Hynes-Ryan, C., Agarwal, S. M., Bourke, R., Cullen, W., Gaughran, F., …O’Donoghue, B. (in press). Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation. Schizophrenia Bulletin, https://doi.org/10.1093/schbul/sbae205

Background Overweight and obesity are highly prevalent in people with severe mental illness (SMI). Antipsychotic-induced weight gain (AIWG) is one of the most commonly reported and distressing side effects of treatment and people living with SMI plac... Read More about Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation.

The digital prescription: A systematic review and meta-analysis of smartphone apps for blood pressure control. (2024)
Journal Article
Motta-Yanac, E., Riley, V., Ellis, N. J., Mankoo, A., & Gidlow, C. J. (in press). The digital prescription: A systematic review and meta-analysis of smartphone apps for blood pressure control. International Journal of Medical Informatics, 195, 105755. https://doi.org/10.1016/j.ijmedinf.2024.105755

Assess the effectiveness of digital health interventions (DHIs) in reducing blood pressure (BP) among individuals with high blood pressure and identify the impact of age, sex, and phone-based delivery methods on BP. A systematic review and meta-analy... Read More about The digital prescription: A systematic review and meta-analysis of smartphone apps for blood pressure control..

Temporal Trends in Mortality Related to Stroke and Atrial Fibrillation in the United States: A 21‐Year Retrospective Analysis of CDC‐WONDER Database (2024)
Journal Article
Ahmad, O., Farooqi, H. A., Ahmed, I., Jamil, A., Nabi, R., Ullah, I., …Mamas, M. A. (2024). Temporal Trends in Mortality Related to Stroke and Atrial Fibrillation in the United States: A 21‐Year Retrospective Analysis of CDC‐WONDER Database. Clinical Cardiology, 47(12), e70058. https://doi.org/10.1002/clc.70058

Aims: Atrial Fibrillation (AF) is one of the most strongly associated risk factors for stroke. Our study aims to analyze changes in mortality from 1999 to 2020 in patients with AF and stroke. Methods: Using the Centre for Disease Control and Preventi... Read More about Temporal Trends in Mortality Related to Stroke and Atrial Fibrillation in the United States: A 21‐Year Retrospective Analysis of CDC‐WONDER Database.

Prediction of Distant Metastasis of Lymph-Node-Negative Primary Breast Cancer From Gene Expression Profiling Using Cox-Boost Regression Model (2024)
Journal Article
Hamidi, O., Amini, P., Tapak, L., Zohrab Beigi, Y., Afshar, S., & Dinu, I. (in press). Prediction of Distant Metastasis of Lymph-Node-Negative Primary Breast Cancer From Gene Expression Profiling Using Cox-Boost Regression Model. Cancer Informatics, 23, https://doi.org/10.1177/11769351241297493

Backgrounds:: Distant metastasis in breast cancer patients contributes to increased breast cancer mortality, highlighting the urgent need for effective predictive strategies. Understanding metastasis mechanisms and identifying relevant biomarkers are... Read More about Prediction of Distant Metastasis of Lymph-Node-Negative Primary Breast Cancer From Gene Expression Profiling Using Cox-Boost Regression Model.

Cost-effectiveness of psychological and psychosocial interventions for adults, children and young people who have self-harmed (2024)
Journal Article
Mavranezouli, I., Pelone, F., Connolly, R., Mughal, F., Witt, K. G., Hawton, K., …Kapur, N. (2024). Cost-effectiveness of psychological and psychosocial interventions for adults, children and young people who have self-harmed. BMJ Mental Health, 27(1), https://doi.org/10.1136/bmjment-2024-301220

Background: Self-harm is a major health issue resulting in high societal costs. Few psychological and psychosocial interventions have shown effectiveness in reducing repeat self-harm. Objective: To assess the cost-effectiveness of psychological and p... Read More about Cost-effectiveness of psychological and psychosocial interventions for adults, children and young people who have self-harmed.

Peripartum Cardiomyopathy and Social Vulnerability: An Epidemiological Analysis of Mortality Outcomes. (2024)
Journal Article
Shahid, M., Ibrahim, R., Ulhaque, T., Nhat, H., Sainbayar, E., Lee, K., & Mamas, M. A. (in press). Peripartum Cardiomyopathy and Social Vulnerability: An Epidemiological Analysis of Mortality Outcomes. Journal of the American Heart Association, 13(21), Article e034825. https://doi.org/10.1161/JAHA.124.034825

Peripartum cardiomyopathy (PPCM) outcomes have been previously linked to demographic and social factors. The social vulnerability index (SVI) is a measure of social vulnerability in the United States. We explored PPCM disparities and the impact of SV... Read More about Peripartum Cardiomyopathy and Social Vulnerability: An Epidemiological Analysis of Mortality Outcomes..

Care gaps among people presenting to the hospital following self-harm: observational study of three emergency departments in England (2024)
Journal Article
Steeg, S., Bickley, H., Clements, C., Quinlivan, L. M., Barlow, S., Monaghan, E., …Kapur, N. (2024). Care gaps among people presenting to the hospital following self-harm: observational study of three emergency departments in England. BMJ Open, 14(10), https://doi.org/10.1136/bmjopen-2024-085672

Objectives: This study aims to examine the proportions of patients referred to mental health, social and voluntary, community and social enterprise (VCSE) services and general practice and to assess care gaps among people presenting to the hospital f... Read More about Care gaps among people presenting to the hospital following self-harm: observational study of three emergency departments in England.

A genome-wide association analysis reveals new pathogenic pathways in gout. (2024)
Journal Article
Major, T. J., Takei, R., Matsuo, H., Leask, M. P., Sumpter, N. A., Topless, R. K., …Merriman, T. R. (in press). A genome-wide association analysis reveals new pathogenic pathways in gout. Nature Genetics, https://doi.org/10.1038/s41588-024-01921-5

Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of go... Read More about A genome-wide association analysis reveals new pathogenic pathways in gout..

Exploring online public survey lifestyle datasets with statistical analysis, machine learning and semantic ontology (2024)
Journal Article
Chatterjee, A., Riegler, M. A., Johnson, M. S., Das, J., Pahari, N., Ramachandra, R., …Bajpai, R. (2024). Exploring online public survey lifestyle datasets with statistical analysis, machine learning and semantic ontology. Scientific Reports, 14(1), 1-24. https://doi.org/10.1038/s41598-024-74539-6

Lifestyle diseases significantly contribute to the global health burden, with lifestyle factors playing a crucial role in the development of depression. The COVID-19 pandemic has intensified many determinants of depression. This study aimed to identi... Read More about Exploring online public survey lifestyle datasets with statistical analysis, machine learning and semantic ontology.

Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project) (2024)
Journal Article
Granviken, F., Meisingset, I., Bach, K., Bones, A. F., Simpson, M. R., Hill, J. C., …Vasseljen, O. (2024). Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project). PAIN, https://doi.org/10.1097/j.pain.0000000000003456

We developed the SupportPrim PT clinical decision support system (CDSS) using the artificial intelligence method case-based reasoning to support personalised musculoskeletal pain management. The aim of this study was to evaluate the effectiveness of... Read More about Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project).

Quality Indicators for the Primary and Community Care of Musculoskeletal Conditions: A Systematic Review: Quality Indicators for MSK Conditions. (2024)
Journal Article
Braybrooke, A., Baraks, K., Burgess, R., Banerjee, A., & Hill, J. (in press). Quality Indicators for the Primary and Community Care of Musculoskeletal Conditions: A Systematic Review: Quality Indicators for MSK Conditions. Archives of Physical Medicine and Rehabilitation, https://doi.org/10.1016/j.apmr.2024.08.022

To identify, appraise, and synthesise common themes from quality indicator (QI) sets designed for the assessment, management, and rehabilitation of musculoskeletal conditions in primary and community care contexts. A systematic search was performed o... Read More about Quality Indicators for the Primary and Community Care of Musculoskeletal Conditions: A Systematic Review: Quality Indicators for MSK Conditions..

Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model (2024)
Working Paper
Shan, Y., Jiang, S., Yu, D., Fan, W., Gao, J., Lu, W., …Wang, C. Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model

Background
As life expectancy increases, so does the risk of age-related diseases and functional disability, which significantly raises the risk of all-cause mortality in older adults. Individuals with disabilities may die up to 20 years earlier tha... Read More about Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model.