All Outputs (32)

An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions (2022)
Journal Article

The steric influences of the triazole side chains in two tripodal chelating ligands tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) and tris[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]amine (TPTA) are explored through structural studies of four... Read More about An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions.

Synthetic Strategies for FRET-Enabled Carbohydrate Active Enzyme Probes (2021)
Book Chapter

Developments in the Chemical Synthesis of Heparin and Heparan Sulfate (2021)
Journal Article

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological importance. As such, their efficiency of synthesis represents a key requirement, to further underst... Read More about Developments in the Chemical Synthesis of Heparin and Heparan Sulfate.

Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy (2021)
Journal Article

The Golgi apparatus requires zinc for its normal function, but the role it plays in these processes at the sub-cellular level is not well-understood due to the lack of appropriate tools to image it. Herein, a small molecule Golgi apparatus targeted p... Read More about Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy.

Subcellular localised small molecule fluorescent probes to image mobile Zn2+ (2020)
Journal Article

Zn2+, as the second most abundant d-block metal in the human body, plays an important role in a wide range of biological processes, and the dysfunction of its homeostasis is related to many diseases, including Type 2 diabetes, Alzheimer's disease and... Read More about Subcellular localised small molecule fluorescent probes to image mobile Zn2+.

Illuminating glycoscience: synthetic strategies for FRET-enabled carbohydrate active enzyme probes (2020)
Journal Article

Carbohydrates are synthesised, refined and degraded by carbohydrate active enzymes. FRET is emerging as a powerful tool to monitor and quantify their activity as well as to test inhibitors as new drug candidates and monitor disease.

A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme. (2020)
Journal Article

The development of a team-based approach to research-led transnational practical chemistry teaching is described in which a team of five Chinese students on an articulated transnational degree programme, supported by a team of academic and technical... Read More about A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme..

Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+ (2019)
Journal Article

Zn2+ plays an important role in the normal function of the endoplasmic reticulum (ER) and its deficiency can cause ER stress, which is related to a wide range of diseases. In order to provide tools to better understand the role of mobile Zn2+ in ER p... Read More about Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+.

An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+ (2019)
Journal Article

Zn2+ is involved in a number of biological processes and its wide-ranging roles at the subcellular level, especially in specific organelles, have not yet been fully established due to a lack of tools to image it effectively. We report a new and effic... Read More about An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+.

Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance (2019)
Journal Article

Inflammatory conditions are frequently accompanied by increased levels of active proteases, and there is rising interest in methods for their detection to monitor inflammation in a point of care setting. In this work, new sensor materials for disposa... Read More about Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance.

Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges (2019)
Journal Article

The surface charge of cells affects cell signaling, cell metabolic processes, adherence to surfaces, and cell proliferation. Our understanding of the role of membrane charges is limited due to the inability to observe changes without interfering, che... Read More about Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges.

Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase (2019)
Journal Article

Peptide cross-linked poly(ethylene glycol) hydrogel has been widely used for drug delivery and tissue engineering. However, the use of this material as a biosensor for the detection of collagenase has not been explored. Proteases play a key role in t... Read More about Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase.

Recent advances in the catalytic oxidation of alkene and alkane substrates using immobilized manganese complexes with nitrogen containing ligands (2019)
Journal Article

In recent years, many supported manganese catalysts for the oxidative transformations of hydrocarbons by various terminal oxidants have been designed and tested. A vast range of inorganic (e.g. silica, carbon, zeolites), organic (e.g. polymers, dendr... Read More about Recent advances in the catalytic oxidation of alkene and alkane substrates using immobilized manganese complexes with nitrogen containing ligands.

Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films (2018)
Conference Proceeding

Peptide cross-linked poly(ethylene glycol) hydrogel is a promising biomaterial that has been used widely for drug delivery and tissue engineering. However, the use of this material as a biosensor material for the detection of collagenase has not been... Read More about Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films.

Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells (2018)
Journal Article

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We... Read More about Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells.

Chelating Rotaxane Ligands as Fluorescent Sensors for Metal Ions (2018)
Journal Article

Although metal-ion-binding interlocked molecules have been under intense investigation for over three decades, their application as scaffolds for the development of sensors for metal ions remains underexplored. In this work, we demonstrate the potent... Read More about Chelating Rotaxane Ligands as Fluorescent Sensors for Metal Ions.

Remarkable increase in the rate of the catalytic epoxidation of electron deficient styrenes through the addition of Sc(OTf)3 to the MnTMTACN catalyst. (2018)
Journal Article

The effect of Lewis acids on the catalytic activity of [Mn2(µ-O)3(TMTACN)2](PF6)2 in the epoxidation of styrenes using hydrogen peroxide as the oxidant has shown that the addition of Sc(OTf)3 at low catalytic loading results in a very significant inc... Read More about Remarkable increase in the rate of the catalytic epoxidation of electron deficient styrenes through the addition of Sc(OTf)3 to the MnTMTACN catalyst..

Aggregation-Induced Emission (AIE) Fluorophore Exhibits a Highly Ratiometric Fluorescent Response to Zn2+ in vitro and in Human Liver Cancer Cells (2017)
Journal Article

Two novel organic fluorophores, containing bis-naphthylamide and quinoline motifs, have been designed and synthesized. One of the fluorophores contains an isobutylene unit and exhibits a significant aggregation-induced emission (AIE) and a remarkable... Read More about Aggregation-Induced Emission (AIE) Fluorophore Exhibits a Highly Ratiometric Fluorescent Response to Zn2+ in vitro and in Human Liver Cancer Cells.

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate (2017)
Journal Article

Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir, has oral bioavailability (25%) limited by intestinal transport (P-glycoprotein), and intestinal degradation (carboxylesterase). However, the influence of luminal pancreatic enzymes is not f... Read More about Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate.

Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click” Reaction Characterized with LAPS and SPIM (2017)
Journal Article

A copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) reaction combined with microcontact printing was used successfully to pattern alkyne-terminated self-assembled organic monolayer-modified silicon surfaces. Despite the absence of a copper peak... Read More about Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click” Reaction Characterized with LAPS and SPIM.