Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

Fluorinated nucleosides, nucleotides and sugar nucleotides (2023)
Journal Article
P Dolan, J., MM Benckendorff, C., A Field, R., & J Miller, G. (2023). Fluorinated nucleosides, nucleotides and sugar nucleotides. Future Medicinal Chemistry, 15(13), 1111-1114. https://doi.org/10.4155/fmc-2023-0159

Reduced order model approaches for predicting the magnetic polarizability tensor for multiple parameters of interest (2023)
Journal Article
Elgy, J., & Ledger, P. D. (2023). Reduced order model approaches for predicting the magnetic polarizability tensor for multiple parameters of interest. Engineering with Computers, 39(6), 4061-4076. https://doi.org/10.1007/s00366-023-01868-x

The design of magnets for magnetic resonance imaging (MRI) scanners requires the numerical simulation of a coupled magneto-mechanical system where the effects that different material parameters and in-service loading conditions have on both imaging a... Read More about Reduced order model approaches for predicting the magnetic polarizability tensor for multiple parameters of interest.

Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial (2023)
Journal Article
Farooq, S., Sheikh, S., Dikomitis, L., Haq, M. M. U., Khan, A. J., Sanauddin, N., …Lewis, M. (2023). Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial. BMJ Open, 13(7), Article e072471. https://doi.org/10.1136/bmjopen-2023-072471

Objectives In low/middle-income countries (LMICs), more than half of patients with first-episode psychosis initially seek treatment from traditional and religious healers as their first care. This contributes to an excessively long duration of untrea... Read More about Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial.

Within- and between-host dynamics of producer and non-producer pathogens (2023)
Journal Article
Pike, V. L., Stevens, E. J., Griffin, A. S., & King, K. C. (2023). Within- and between-host dynamics of producer and non-producer pathogens. Parasitology, https://doi.org/10.1017/S0031182023000586

For infections to be maintained in a population, pathogens must compete to colonize hosts and transmit between them. We use an experimental approach to investigate within-and-between host dynamics using the pathogen Pseudomonas aeruginosa and the ani... Read More about Within- and between-host dynamics of producer and non-producer pathogens.

Three Saturn-mass planets transiting F-type stars revealed with TESS and HARPS: TOI-615b, TOI-622b, and TOI-2641b (2023)
Journal Article
Psaridi, A., Bouchy, F., Lendl, M., Akinsanmi, B., Stassun, K. G., Smalley, B., …Zapata, A. (2023). Three Saturn-mass planets transiting F-type stars revealed with TESS and HARPS: TOI-615b, TOI-622b, and TOI-2641b. Astronomy & Astrophysics, 675, A39. https://doi.org/10.1051/0004-6361/202346406

While the sample of confirmed exoplanets continues to grow, the population of transiting exoplanets around early-type stars is still limited. These planets allow us to investigate the planet properties and formation pathways over a wide range of stel... Read More about Three Saturn-mass planets transiting F-type stars revealed with TESS and HARPS: TOI-615b, TOI-622b, and TOI-2641b.

Decellularisation and characterisation of porcine pleura for lung tissue engineering (2023)
Journal Article
Vikranth, T., Dale, T., & Forsyth, N. R. (in press). Decellularisation and characterisation of porcine pleura for lung tissue engineering. bioRxiv, https://doi.org/10.1101/2023.06.20.545830

Decellularisation offers a broad range of biomimetic scaffolds of allogeneic and xenogeneic origins, exhibiting innate tissue-specific characteristics. We explored a physico-chemical method for decellularising porcine pleural membranes (PPM) as poten... Read More about Decellularisation and characterisation of porcine pleura for lung tissue engineering.

The establishment, maintenance, and adaptation of high- and low-impact chronic pain: a framework for biopsychosocial pain research. (2023)
Journal Article
Eccleston, C., Begley, E., Birkinshaw, H., Choy, E., Crombez, G., Fisher, E., …Keogh, E. (in press). The establishment, maintenance, and adaptation of high- and low-impact chronic pain: a framework for biopsychosocial pain research. PAIN, 164(10), 2143-2147. https://doi.org/10.1097/j.pain.0000000000002951

An empirical investigation of intuitions about uptake (2023)
Journal Article
Fisher, S. A., A. Fisher, S., Francis, K. B., B. Francis, K., & Townsend, L. (2023). An empirical investigation of intuitions about uptake. Inquiry, 1-33. https://doi.org/10.1080/0020174X.2023.2220359

Since Austin’s introduction of the locutionary-illocutionary-perlocutionary distinction, it has been a matter of debate within speech act theory whether illocutionary acts like promising, warning, refusing and telling require audience ‘uptake’ in ord... Read More about An empirical investigation of intuitions about uptake.

Refined parameters of the HD 22946 planetary system and the true orbital period of planet d (2023)
Journal Article
Garai, Z., Osborn, H. P., Gandolfi, D., Brandeker, A., Sousa, S. G., Lendl, M., …Walton, N. (2023). Refined parameters of the HD 22946 planetary system and the true orbital period of planet d. Astronomy & Astrophysics, 674, Article A44. https://doi.org/10.1051/0004-6361/202345943

Context. Multi-planet systems are important sources of information regarding the evolution of planets. However, the long-period planets in these systems often escape detection. These objects in particular may retain more of their primordial character... Read More about Refined parameters of the HD 22946 planetary system and the true orbital period of planet d.

Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort. (2023)
Journal Article
Chew, N. W. S., Chong, B., Kuo, S. M., Jayabaskaran, J., Cai, M., Zheng, H., …Chan, M. Y. (2023). Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort. The Lancet Regional Health - Western Pacific, 37, Article 100803. https://doi.org/10.1016/j.lanwpc.2023.100803

Understanding the trajectories of metabolic risk factors for acute myocardial infarction (AMI) is necessary for healthcare policymaking. We estimated future projections of the incidence of metabolic diseases in a multi-ethnic population with AMI. The... Read More about Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort..

Chemical Diversification of Carbocyclic Fluorinated Pyrimidine Nucleosides: Introducing 2'-Arabino Analogues and Ring Unsaturation (2023)
Journal Article
Benckendorff, C. M. M., Hawes, C. S., Smith, M., & Miller, G. J. (2023). Chemical Diversification of Carbocyclic Fluorinated Pyrimidine Nucleosides: Introducing 2'-Arabino Analogues and Ring Unsaturation. SYNLETT, 35(06), 659-664. https://doi.org/10.1055/a-2079-9310

Analogues of the canonical nucleosides have a longstanding presence and proven capability within medicinal chemistry and drug-discovery research. Herein, we report chemical diversification of carbocyclic pyrimidine nucleosides containing CF2 and CHF... Read More about Chemical Diversification of Carbocyclic Fluorinated Pyrimidine Nucleosides: Introducing 2'-Arabino Analogues and Ring Unsaturation.

Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides. (2023)
Journal Article
Porter, J., Parisi, D., Miller, T., Cheallaigh, A. N., & Miller, G. J. (2023). Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides. Carbohydrate Research, 530, Article 108854. https://doi.org/10.1016/j.carres.2023.108854

Amphiphilic glycoconjugates offer an important prospect for development as chemical biology tools and biosurfactants. The chemical synthesis of such materials is required to expedite such prospect, compounded by the example of oleyl glycosides. Herei... Read More about Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides..

Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset) (2023)
Journal Article
Terry, J., Ross, R. M., Nagy, T., Salgado, M., Garrido-Vásquez, P., Sarfo, J. O., …Field, A. P. (in press). Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset). Journal of Open Psychology Data, 11(1), Article 8. https://doi.org/10.5334/jopd.80

This large, international dataset contains survey responses from N = 12,570 students from 100 universities in 35 countries, collected in 21 languages. We measured anxieties (statistics, mathematics, test, trait, social interaction, performance, creat... Read More about Data from an International Multi-Centre Study of Statistics and Mathematics Anxieties and Related Variables in University Students (the SMARVUS Dataset).

Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release (2023)
Journal Article
Davies, R., Allen, S., Mennan, C., Platt, M., Wright, K., & Kehoe, O. (2023). Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release. International Journal of Molecular Sciences, 24(11), 9242. https://doi.org/10.3390/ijms24119242

The immunomodulatory properties of MSCs can be recreated using their extracellular vesicles (EVs). Yet, the true capabilities of the MSC EVs cannot be distinguished from contaminating bovine EVs and protein derived from supplemental foetal bovine ser... Read More about Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release.

Recognition, remember-know, and confidence judgments: no evidence of cross-contamination here! (2023)
Journal Article
Williams, H. L., Bodner, G. E., & Lindsay, D. S. (2023). Recognition, remember-know, and confidence judgments: no evidence of cross-contamination here!. Memory, 31(7), 905-917. https://doi.org/10.1080/09658211.2023.2207804

We report three experiments designed to reveal the mechanisms that underlie subjective experiences of recognition by examining effects of how those experiences are measured. Prior research has explored the potential influences of collecting metacogni... Read More about Recognition, remember-know, and confidence judgments: no evidence of cross-contamination here!.

Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. (2023)
Other
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., …Galizi, R. (2023). Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. [PREPRINT]

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome..

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence (2023)
Journal Article
Jangir, P., Ogunlana, L., Szili, P., Czikkely, M., P Shaw, L., Stevens, E. J., …R MacLean, C. (2023). The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence. eLife, 12, 1-22. https://doi.org/10.7554/elife.84395

Antimicrobial peptides (AMPs) offer a promising solution to the antibiotic resistance crisis. However, an unresolved serious concern is that the evolution of resistance to therapeutic AMPs may generate cross-resistance to host AMPs, compromising a co... Read More about The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence.

Mapping the distribution of OB stars and associations in Auriga (2023)
Journal Article
Quintana, A. L., Wright, N. J., & Jeffries, R. D. (2023). Mapping the distribution of OB stars and associations in Auriga. Monthly Notices of the Royal Astronomical Society, 522(2), 3124-3137. https://doi.org/10.1093/mnras/stad1160

OB associations are important probes of recent star formation and Galactic structure. In this study, we focus on the Auriga constellation, an important region of star formation due to its numerous young stars, star-forming regions, and open clusters.... Read More about Mapping the distribution of OB stars and associations in Auriga.

Rural businesses and levelling up: A rural-urban analysis of business innovation and exporting in England's north and midlands (2023)
Journal Article
Tiwasing, P., Gorton, M., Phillipson, J., & Maioli, S. (2023). Rural businesses and levelling up: A rural-urban analysis of business innovation and exporting in England's north and midlands. Journal of Rural Studies, 100, Article ARTN 103007. https://doi.org/10.1016/j.jrurstud.2023.103007

In the face of persistent and widening regional imbalances in economic and social outcomes, the UK Government seeks to ‘level up’ less prosperous communities, reigniting debates on the relationships between geography and business innovation. A key qu... Read More about Rural businesses and levelling up: A rural-urban analysis of business innovation and exporting in England's north and midlands.