A CRISPR-Cas9 sex-ratio distortion system for genetic control (2016)
Journal Article
Galizi, R., Hammond, A., Kyrou, K., Taxiarchi, C., Bernardini, F., O’Loughlin, S. M., Papathanos, P.-A., Nolan, T., Windbichler, N., & Crisanti, A. (2016). A CRISPR-Cas9 sex-ratio distortion system for genetic control. Scientific Reports, 31139 - ?. https://doi.org/10.1038/srep31139

Genetic control aims to reduce the ability of insect pest populations to cause harm via the release of modified insects. One strategy is to bias the reproductive sex ratio towards males so that a population decreases in size or is eliminated altogeth... Read More about A CRISPR-Cas9 sex-ratio distortion system for genetic control.

Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-Length Genomes (2016)
Book Chapter
(2016). Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-Length Genomes. In Proceedings of the Artificial Life Conference 2016 (172-179)

Monotonicity of fitness landscapes and mutation rate control (2016)
Journal Article
Channon. (2016). Monotonicity of fitness landscapes and mutation rate control. Journal of Mathematical Biology, 1491-1524. https://doi.org/10.1007/s00285-016-0995-3

A common view in evolutionary biology is that mutation rates are minimised. However, studies in combinatorial optimisation and search have shown a clear advantage of using variable mutation rates as a control parameter to optimise the performance of... Read More about Monotonicity of fitness landscapes and mutation rate control.

The genomic basis of parasitism in the Strongyloides clade of nematodes. (2016)
Journal Article
(2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature genetics, 299 - 307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes..