Applying electron microscopy analysis to assess neural tissue engineering outcomes (2024)
Thesis
Lindop, G. E. (2024). Applying electron microscopy analysis to assess neural tissue engineering outcomes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/884963

Spinal cord injury (SCI) has a major socio-economic impact with treatments providing little to no functional recovery due to the SCI environment hindering regeneration through chemical and physical barriers. Novel approaches to alter the injury envir... Read More about Applying electron microscopy analysis to assess neural tissue engineering outcomes.

Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models (2023)
Thesis
Ali, R. (2023). Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models. (Thesis). Keele University

Alzheimer’s disease is the most common type of dementia characterised by cognitive impairments such as memory loss as well as behavioural symptoms like depression and aggression. The hallmark of the disease is the accumulation of beta-Amyloid (Aβ) as... Read More about Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models.

A Scoping Review of Transgender Policies in the 15 Most Commonly Played UK Professional Sports (2023)
Journal Article
McLarnon, M., Thornton, J., Knudson, G., Jones, N., Glover, D., Murray, A., …Heron, N. (2023). A Scoping Review of Transgender Policies in the 15 Most Commonly Played UK Professional Sports. International Journal of Environmental Research and Public Health, 20(4), 3568. https://doi.org/10.3390/ijerph20043568

INTRODUCTION: There has been much debate recently on the participation of transgender and gender-diverse (TGD) athletes in sport, particularly in relation to fairness, safety and inclusion. The 2021 IOC Framework on Fairness, Inclusion and Non-discri... Read More about A Scoping Review of Transgender Policies in the 15 Most Commonly Played UK Professional Sports.

Anxiety predicts impulsive-compulsive behaviours in Parkinson’s Disease: clinical relevance and theoretical implications (2022)
Journal Article
Di Rosa, E., Mapelli, D., Ronconi, L., Macchia, E., Gentili, C., Bisiacchi, P., & Edelstyn, N. (2022). Anxiety predicts impulsive-compulsive behaviours in Parkinson’s Disease: clinical relevance and theoretical implications. Journal of Psychiatric Research, 220-229. https://doi.org/10.1016/j.jpsychires.2022.01.052

Patients with Parkinson’s Disease (PD) often present symptoms of anxiety, depression and apathy. These negative affect manifestations have been recently associated with the presence of Impulsive-Compulsive Behaviours (ICBs). However, their relation w... Read More about Anxiety predicts impulsive-compulsive behaviours in Parkinson’s Disease: clinical relevance and theoretical implications.

Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials (2022)
Thesis
Chowdhury, F. (2022). Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials. (Thesis). Keele University

Oligodendrocyte lineage and neuronal cells are essential neural populations required for axonal remyelination after spinal cord injury (SCI). Injection of an exogenous cell population into the site of neural injury has posed translational barriers, s... Read More about Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials.

What can Jane Goodall teach us about addiction? (2022)
Journal Article
Frisher. (2023). What can Jane Goodall teach us about addiction?. Drugs: Education, Prevention, and Policy, 30(1), 55-59. https://doi.org/10.1080/09687637.2022.2033164

In 2017, Jane Goodall, the well-known primatologist, wrote a letter to the United States Food and Drug Administration criticising the use of animals to test brain-based theories of addiction. She reasoned that we already know about addiction by obser... Read More about What can Jane Goodall teach us about addiction?.

Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies (2021)
Thesis
Mogas Barcons, A. (2021). Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies. (Thesis). Keele University

Spinal cord injury is a devastating condition affecting thousands of people every year. The spinal cord does not have the intrinsic capacity for regeneration due to a complex cascade of physical and chemical barriers that prevent axonal growth and le... Read More about Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies.

Improving Sleep Quality Leads to Better Mental Health: A Meta-Analysis of Randomised Controlled Trials (2021)
Journal Article
Scott, A., Webb, T. L., Martyn-St James, M., Rowse, G., & Weich, S. (2021). Improving Sleep Quality Leads to Better Mental Health: A Meta-Analysis of Randomised Controlled Trials. Sleep Medicine Reviews, 60, Article 101556. https://doi.org/10.31234/osf.io/t2efb

<p>The extent to which sleep is causally related to mental health is unclear. One way to test the causal link is to evaluate the extent to which interventions that improve sleep quality also improve mental health. We conducted a meta-analysis of rand... Read More about Improving Sleep Quality Leads to Better Mental Health: A Meta-Analysis of Randomised Controlled Trials.

Stem cell sprays for neurological injuries: a perspective (2021)
Journal Article
Woods, W., Evans, D., Mogas Barcons, A., Tzerakis, N., Adams, C., & Chari, D. (2021). Stem cell sprays for neurological injuries: a perspective. Emerging Topics in Life Sciences, https://doi.org/10.1042/ETLS20210113

<jats:p>Injuries to the brain and spinal cord have major clinical consequences with high costs for healthcare systems. Neural cell transplantation therapies have significant translational potential to promote regeneration post-injury with clinical tr... Read More about Stem cell sprays for neurological injuries: a perspective.

Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study (2021)
Journal Article
Roffe. (2021). Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study. Diagnostic and Prognostic Research, https://doi.org/10.1186/s41512-021-00098-3

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Rapid treatment of stroke improves outcomes, but accurate early recognition can be challenging. Between 20 and 40% of patients suspected to have stroke by ambulan... Read More about Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study.

Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex (2021)
Thesis
Pettitt, G. (2021). Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex. (Thesis). Keele University

Despite receiving the second largest dopaminergic projection from the ventral tegmental area (VTA) and having a pivotal role in conveying non-spatial information received from sensory cortices, the physiological functions of the lateral entorhinal co... Read More about Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex.

Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex (2021)
Thesis
Wells, T. R. (2021). Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex. (Thesis). Keele University

The entorhinal cortex serves as the interface region between allocortical input and the hippocampus, with current theories suggesting that the region is involved in memory encoding, with dopamine serving as a “motivational currency” provided to memor... Read More about Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex.

Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models (2021)
Thesis
Green, E. L. (2021). Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models. (Thesis). Keele University

Parkinson’s disease (PD) is characterised by motor symptoms caused by degeneration of dopaminergic neurons in the substantia nigra. The cause remains elusive and current treatments cannot halt or reverse progression. This thesis explores the effects... Read More about Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models.

Use and evaluation of assistive technologies for upper limb function in tetraplegia (2021)
Journal Article
Readioff, R., Kamran Siddiqui, Z., Stewart, C., Fulbrook, L., O’Connor, R. J., & Chadwick, E. K. (2021). Use and evaluation of assistive technologies for upper limb function in tetraplegia. Journal of Spinal Cord Medicine, 45(6), 1 - 12. https://doi.org/10.1080/10790268.2021.1878342

Context More than half of all spinal cord injuries (SCI) occur at the cervical level leading to loss of upper limb function, restricted activity and reduced independence. Several technologies have been developed to assist with upper limb functions in... Read More about Use and evaluation of assistive technologies for upper limb function in tetraplegia.

Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex (2020)
Thesis
Harvey, L. A. (2020). Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex. (Thesis). Keele University

Projection neurons located in the superficial layers of the entorhinal cortex provide the hippocampus with nearly all its sensory input. This innervation occurs via multiple discrete pathways to different targets within the hippocampus, including the... Read More about Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex.

New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies (2020)
Thesis
Basit, R. H. (2020). New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418094

Penetrating traumatic brain injury (pTBI) causes significant neural damage and debilitation. The management of pTBI is largely supportive currently, with no clinically established regenerative therapies. Researchers have previously evaluated the rege... Read More about New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies.

Developing neural transplant cell sprays for neurological injuries (2020)
Thesis
Woods, W. A. (2020). Developing neural transplant cell sprays for neurological injuries. (Thesis). Keele University

Regeneration of the central nervous system following penetrating traumatic brain injury (pTBI) represents a significant clinical challenge. Neural cell therapies have the potential to promote regeneration in central neural injury. However, such thera... Read More about Developing neural transplant cell sprays for neurological injuries.

Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans (2020)
Journal Article
Dimmock, M., Abubakar, A. B., Bautista, T. G., Mazzone, S. B., & Farrell, M. J. (2021). Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans. Chest, 159(3), 1136-1146. https://doi.org/10.1016/j.chest.2020.08.2105

BACKGROUND: Cough is a defense mechanism that protects the airways and lungs in response to airway irritation. The sensory neurons involved in detecting airway irritants and the neural pathways mediating cough share similarities with those that encod... Read More about Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans.

Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases (2020)
Journal Article
Bowerman, M. (2020). Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases. Brain Sciences, 10(9), Article 633. https://doi.org/10.3390/brainsci10090633

Note: In lieu of an abstract, this is an excerpt from the first page.

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), severely impact the function of neuronal cells in the brain... Read More about Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases.

Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial. (2020)
Journal Article
Farooq. (2020). Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial. British Journal of Psychiatry, 623-629. https://doi.org/10.1192/bjp.2020.138

BACKGROUND: With the development of evidence-based interventions for treatment of priority mental health conditions in humanitarian settings, it is important to establish the cost-effectiveness of such interventions to enable their scale-up. AIMS: To... Read More about Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial..