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Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models (2023)
Thesis

Alzheimer’s disease is the most common type of dementia characterised by cognitive impairments such as memory loss as well as behavioural symptoms like depression and aggression. The hallmark of the disease is the accumulation of beta-Amyloid (Aβ) as... Read More about Alzheimer's Disease: Investigating the neuroprotective role of Polyunsaturated fatty acids against β-Amyloid accumulation using SH-SY5Y cell models.

Anxiety predicts impulsive-compulsive behaviours in Parkinson’s Disease: clinical relevance and theoretical implications (2022)
Journal Article

Patients with Parkinson’s Disease (PD) often present symptoms of anxiety, depression and apathy. These negative affect manifestations have been recently associated with the presence of Impulsive-Compulsive Behaviours (ICBs). However, their relation w... Read More about Anxiety predicts impulsive-compulsive behaviours in Parkinson’s Disease: clinical relevance and theoretical implications.

Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies (2021)
Thesis

Spinal cord injury is a devastating condition affecting thousands of people every year. The spinal cord does not have the intrinsic capacity for regeneration due to a complex cascade of physical and chemical barriers that prevent axonal growth and le... Read More about Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies.

Improving Sleep Quality Leads to Better Mental Health: A Meta-Analysis of Randomised Controlled Trials (2021)
Journal Article

The extent to which sleep is causally related to mental health is unclear. One way to test the causal link is to evaluate the extent to which interventions that improve sleep quality also improve mental health. We conducted a meta-analysis of randomi... Read More about Improving Sleep Quality Leads to Better Mental Health: A Meta-Analysis of Randomised Controlled Trials.

Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study (2021)
Journal Article

Abstract Background Rapid treatment of stroke improves outcomes, but accurate early recognition can be challenging. Between 20 and 40% of patients suspected to have stroke by ambulance and emergency department staff later receive a non-stroke ‘mimic’... Read More about Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study.

Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models (2021)
Thesis

Parkinson’s disease (PD) is characterised by motor symptoms caused by degeneration of dopaminergic neurons in the substantia nigra. The cause remains elusive and current treatments cannot halt or reverse progression. This thesis explores the effects... Read More about Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models.

Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex (2020)
Thesis

Projection neurons located in the superficial layers of the entorhinal cortex provide the hippocampus with nearly all its sensory input. This innervation occurs via multiple discrete pathways to different targets within the hippocampus, including the... Read More about Dopaminergic modulation of superficial layer projection neuron excitability in the lateral entorhinal cortex.

Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans (2020)
Journal Article

BACKGROUND: Cough is a defense mechanism that protects the airways and lungs in response to airway irritation. The sensory neurons involved in detecting airway irritants and the neural pathways mediating cough share similarities with those that encod... Read More about Behavioral and Regional Brain Responses to Inhalation of Capsaicin Modified by Painful Conditioning in Humans.

Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases (2020)
Journal Article

Note: In lieu of an abstract, this is an excerpt from the first page. Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), severely impact the function of neuronal cells in the brain... Read More about Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases.

Incentive-driven decision-making networks in de novo and drug-treated Parkinson’s disease patients with impulsive-compulsive behaviors: A systematic review of neuroimaging studies (2020)
Journal Article

Background: In Parkinson’s disease (PD), impulsive-compulsive behaviors (ICBs) may develop as side-effect of dopaminergic medications. Abnormal incentive-driven decision-making, which is supported by the cognitive control and motivation interaction,... Read More about Incentive-driven decision-making networks in de novo and drug-treated Parkinson’s disease patients with impulsive-compulsive behaviors: A systematic review of neuroimaging studies.

Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial. (2020)
Journal Article

BACKGROUND: With the development of evidence-based interventions for treatment of priority mental health conditions in humanitarian settings, it is important to establish the cost-effectiveness of such interventions to enable their scale-up. AIMS: To... Read More about Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial..