Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease (2024)
Thesis
Hassan, H. (2024). Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849849

Alzheimer's disease (AD) is the most common form of dementia, affecting around 26 million people worldwide, with an expected four-fold increase by 2050. It is characterized by cognitive and mental deficits and is caused by the accumulation of toxic a... Read More about Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease.

The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation (2024)
Thesis
Essel, D. Y. (2024). The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849930

Augmented reality (AR) generates immersive, engaging environments that has been shown to improve learners’ motivation, knowledge and spatial awareness in some science-based subjects. Therefore, this study aimed to design, then evaluate the effectiven... Read More about The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation.

Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma (2024)
Thesis
Franklin, L. H. K. (2024). Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775420

Background: In 2020, the NHS developed its carbon net zero goals and highlighted metered dose inhalers (MDIs) as a focal point for change. MDIs are commonly prescribed for asthma in primary care and contain potent greenhouse gases, accounting for 3%... Read More about Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma.

FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice? (2023)
Thesis
Dowling, L. M. M. (2023). FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice?. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674513

Cancer incidence rates are increasing world-wide including in the UK. An increase in cancer cases puts further pressure on pathology departments that are often already struggling to meet targets to diagnose cancers in a timely manner. Delays in diagn... Read More about FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice?.

Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy (2023)
Thesis
Storey, E. C. (2023). Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674333

LMNA-related congenital muscular dystrophy (L-CMD) is a rare disorder predominantly causing muscle weakness and wasting, over time, leading to development of dysphagia and life-threating respiratory insufficiency, and sometimes cardiac arrhythmias. T... Read More about Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy.

Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques (2023)
Thesis
Xie, B. (2023). Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674529

Non-degradable and biodegradable implants inevitably generate debris or degradation products in the body, and these induce acute and chronic inflammation. Polyglycolic acid (PGA) is a simple linear aliphatic polyester with a wide set of medical appli... Read More about Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques.

The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study (2023)
Thesis
Ballantyne, S. J. (2023). The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study. (Thesis). Keele University

Introduction
Globally, Chronic Obstructive Pulmonary Disease (COPD) is one of the most important non-communicable diseases with a progressive downhill course.1 Guidelines recommend regular review of patients with COPD.2 In the UK traditionally, ann... Read More about The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study.

Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites (2023)
Journal Article
Li, C., Barroeta, A. B., Wong, S. S., Kim, H. J., Pathak, M., Dreveny, I., …Emsley, J. (2023). Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites. Journal of Thrombosis and Haemostasis, 21(9), 2378-2389. https://doi.org/10.1016/j.jtha.2023.03.042

Background
High–molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK). HK is both a substrate and a cofactor for activated plasma kallikrein, and the principal exosite interactions occur between PK N-termi... Read More about Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites.

Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary (2022)
Journal Article
Fuller, H., & Storey, E. (2022). Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary. Cells, https://doi.org/10.3390/cells11244065

Mutations in genes encoding proteins associated with the linker of nucleoskel-eton and cytoskeleton (LINC) complex within the nuclear envelope cause dif-ferent diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous... Read More about Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary.

Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England (2022)
Thesis
Thayer, N. M. (2022). Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England. (Thesis). Keele University

In England, community pharmacies provide services commissioned either nationally or locally. Local commissioning exhibits variation in specification and implementation, exemplified by Emergency Hormonal Contraception (EHC) services. A literature revi... Read More about Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England.

Remote control healing for osteoarthritis repair (2022)
Thesis
Echevarria, I. (2022). Remote control healing for osteoarthritis repair. (Thesis). Keele University

Articular cartilage is a key tissue for the normal functioning of the joints, with a trend for degradation with aging and physical activity. The lack of vascularisation hinders the self-repair, and often a scar tissue replaces the damaged cartilage,... Read More about Remote control healing for osteoarthritis repair.

Determining the role of epigenetics in telomerase regulation (2022)
Thesis
Dogan, F. (2022). Determining the role of epigenetics in telomerase regulation. (Thesis). Keele University

Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization. Telomerase macromolecule is the primary enzyme responsible for telomere elongation. Telom... Read More about Determining the role of epigenetics in telomerase regulation.

Phenotypic characterization of regional human meniscus progenitor cells. (2022)
Journal Article
(2022). Phenotypic characterization of regional human meniscus progenitor cells. Frontiers in Bioengineering and Biotechnology, 1003966 - ?. https://doi.org/10.3389/fbioe.2022.1003966

Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues. In... Read More about Phenotypic characterization of regional human meniscus progenitor cells..

Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking. (2022)
Journal Article
Reynisson. (2022). Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2022.128909

Tyrosyl-DNA phosphodiesterase 1(TDP1) is a promising target for a new therapy in oncological disease as an adjunct to topoisomerase 1 (TOP1) drugs. In this paper, novel thiazolidin-4-one derivatives with a benzyl and monoterpene substituents were syn... Read More about Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking..

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation (2022)
Journal Article
Mottershead. (2022). Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation. https://doi.org/10.22074/CELLJ.2022.8155

Objective: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation.

A clinical pharmacists role in primary general practice (2022)
Journal Article
(2022). A clinical pharmacists role in primary general practice. The Journal of Academic Development and Education, https://doi.org/10.21252/y0q3-sn26

Clinical pharmacist leaders are valued by the NHS because they are well educated, demonstrating excellent analytical and evidence-based thinking skills and professional competency. This reliability often stems from seeing the pharmacy team accepting... Read More about A clinical pharmacists role in primary general practice.

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study (2022)
Journal Article
Simons, G., Ismail, N., Sandhu, K., Mallen, C. D., Stack, R. J., Pontefract, S., …Falahee, M. (in press). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 6, Article 50. https://doi.org/10.1186/s41927-022-00280-0

<h4>Background: </h4> Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. Howeve... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study.

Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine (2022)
Journal Article
Dale. (2022). Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine. Tissue engineering. Part A, 249 - 250. https://doi.org/10.1089/ten.tea.2022.29030.abstracts

*Purpose/Objectives: Prolonged alveolar air leaks as post-surgical complications to routine lung resections and biopsies are a significant cause for patient morbidity. Extended duration of chest tube drainage and emergency revision surgeries are the... Read More about Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine.

Exploring community pharmacists' use of health literacy interventions in their everyday practice. (2022)
Journal Article
White, S., & Cork, T. (2022). Exploring community pharmacists' use of health literacy interventions in their everyday practice. Research in Social and Administrative Pharmacy, 18(11), 3948-3952. https://doi.org/10.1016/j.sapharm.2022.06.007

BACKGROUND: Limited health literacy often results in people inadequately understanding medicines-related information and subsequently not taking medicines as prescribed. Using health literacy interventions is important for community pharmacists, as t... Read More about Exploring community pharmacists' use of health literacy interventions in their everyday practice..

Educational supervision, assessment and feedback for pharmacists (2022)
Journal Article
O'Byrne, R., & Warren, S. (2022). Educational supervision, assessment and feedback for pharmacists. Pharmaceutical Journal, https://doi.org/10.1211/pj.2022.1.148078

Workplace learning has formed part of preregistration training (now foundation training) for many years, and supervision of this is becoming more embedded into pharmacy education and development — both at foundation and advanced level. Effective supe... Read More about Educational supervision, assessment and feedback for pharmacists.