Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells (2024)
Thesis
Alfred, K. I. Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/1015802

Extracellular vesicles (EVs) are nanoscale, lipid-bound particles carrying bioactive molecules produced by cells. Mesenchymal stem cells (MSC) are preferred sources for producing therapeutically relevant EVs (MSC-EVs). Nonetheless, harnessing MSC-EVs... Read More about Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells.

Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate (2024)
Thesis
Logan, S. J. Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956315

Background
Methotrexate is recommended as initial disease modifying anti-rheumatic drug (DMARD) therapy to treat Rheumatoid Arthritis (RA). Rheumatology nurses provide information in DMARD counselling consultations to support people to take treatme... Read More about Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate.

Textile based medical devices and their role in sustainable health systems (2024)
Thesis
Morris, H. V. Textile based medical devices and their role in sustainable health systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/956321

The field of medical textiles is one of the fastest growing areas within the technical textiles sector of the textile industry. Part of this expansion is because of advances in technology, such as nanotechnology, electrospinning, and the ability to i... Read More about Textile based medical devices and their role in sustainable health systems.

The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope (2024)
Journal Article
Mercer, L., Abhishek, A., Kavirayani, A., Ahmed, A., Davidson, A., Foulkes, A., …Galloway, J. (in press). The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(3), Article rkae077. https://doi.org/10.1093/rap/rkae077

Lay Summary: What does this mean for patients? A revised guideline, produced by the British Society for Rheumatology (BSR), will provide up-to-date information about the safe prescribing and monitoring of the effects of non-biologic (or conventional... Read More about The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope.

Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug (2024)
Journal Article
Porter, J., Noble, A. R., Signoret, N., Fascione, M. A., & Miller, G. J. (in press). Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug. ACS Omega, 9(29), 31703-31713. https://doi.org/10.1021/acsomega.4c02417

Nucleoside analogues are established treatments for cancer and viral infection. Gemcitabine is a commonly employed nucleoside analogue displaying anticancer properties against a range of tumor types but is rapidly inactivated in vivo. Efforts to bols... Read More about Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug.

The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation (2024)
Thesis
Essel, D. Y. (2024). The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849930

Augmented reality (AR) generates immersive, engaging environments that has been shown to improve learners’ motivation, knowledge and spatial awareness in some science-based subjects. Therefore, this study aimed to design, then evaluate the effectiven... Read More about The use of a Pharma Compounds augmented reality educational tool in sixth form and undergraduate students: a mixed methods evaluation.

Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease (2024)
Thesis
Hassan, H. (2024). Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/849849

Alzheimer's disease (AD) is the most common form of dementia, affecting around 26 million people worldwide, with an expected four-fold increase by 2050. It is characterized by cognitive and mental deficits and is caused by the accumulation of toxic a... Read More about Neuroprotective and anti-inflammatory potentials of rutin in an in vitro model of Alzheimer's disease.

Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma (2024)
Thesis
Franklin, L. H. K. (2024). Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775420

Background: In 2020, the NHS developed its carbon net zero goals and highlighted metered dose inhalers (MDIs) as a focal point for change. MDIs are commonly prescribed for asthma in primary care and contain potent greenhouse gases, accounting for 3%... Read More about Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma.

Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy (2023)
Thesis
Storey, E. C. (2023). Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674333

LMNA-related congenital muscular dystrophy (L-CMD) is a rare disorder predominantly causing muscle weakness and wasting, over time, leading to development of dysphagia and life-threating respiratory insufficiency, and sometimes cardiac arrhythmias. T... Read More about Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy.

FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice? (2023)
Thesis
Dowling, L. M. M. (2023). FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice?. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674513

Cancer incidence rates are increasing world-wide including in the UK. An increase in cancer cases puts further pressure on pathology departments that are often already struggling to meet targets to diagnose cancers in a timely manner. Delays in diagn... Read More about FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice?.

Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques (2023)
Thesis
Xie, B. (2023). Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674529

Non-degradable and biodegradable implants inevitably generate debris or degradation products in the body, and these induce acute and chronic inflammation. Polyglycolic acid (PGA) is a simple linear aliphatic polyester with a wide set of medical appli... Read More about Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques.

The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study (2023)
Thesis
Ballantyne, S. J. (2023). The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study. (Thesis). Keele University

Introduction
Globally, Chronic Obstructive Pulmonary Disease (COPD) is one of the most important non-communicable diseases with a progressive downhill course.1 Guidelines recommend regular review of patients with COPD.2 In the UK traditionally, ann... Read More about The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study.

Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites (2023)
Journal Article
Li, C., Barroeta, A. B., Wong, S. S., Kim, H. J., Pathak, M., Dreveny, I., …Emsley, J. (2023). Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites. Journal of Thrombosis and Haemostasis, 21(9), 2378-2389. https://doi.org/10.1016/j.jtha.2023.03.042

Background
High–molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK). HK is both a substrate and a cofactor for activated plasma kallikrein, and the principal exosite interactions occur between PK N-termi... Read More about Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites.

Latonduine-1-Amino-Hydantoin Hybrid, Triazole-Fused Latonduine Schiff Bases and Their Metal Complexes: Synthesis, X-ray and Electron Diffraction, Molecular Docking Studies and Antiproliferative Activity (2023)
Journal Article
Wittmann, C., Gruene, T., Prado-Roller, A., Aranđelović, S., Reynisson, J., & Arion, V. B. (2023). Latonduine-1-Amino-Hydantoin Hybrid, Triazole-Fused Latonduine Schiff Bases and Their Metal Complexes: Synthesis, X-ray and Electron Diffraction, Molecular Docking Studies and Antiproliferative Activity. Inorganics, 11(1), Article 30. https://doi.org/10.3390/inorganics11010030

A series of latonduine derivatives, namely 11-nitro-indolo[2,3-d]benzazepine-7-(1-amino-hydantoin) (B), triazole-fused indolo[2,3-d]benzazepine-based Schiff bases HL1 and HL2 and metal complexes [M(p-cymene)(HL1)Cl]Cl, where M = Ru (1), Os (2), and [... Read More about Latonduine-1-Amino-Hydantoin Hybrid, Triazole-Fused Latonduine Schiff Bases and Their Metal Complexes: Synthesis, X-ray and Electron Diffraction, Molecular Docking Studies and Antiproliferative Activity.

Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary (2022)
Journal Article
Fuller, H., & Storey, E. (2022). Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary. Cells, https://doi.org/10.3390/cells11244065

Mutations in genes encoding proteins associated with the linker of nucleoskel-eton and cytoskeleton (LINC) complex within the nuclear envelope cause dif-ferent diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous... Read More about Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary.

Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England (2022)
Thesis
Thayer, N. M. (2022). Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England. (Thesis). Keele University

In England, community pharmacies provide services commissioned either nationally or locally. Local commissioning exhibits variation in specification and implementation, exemplified by Emergency Hormonal Contraception (EHC) services. A literature revi... Read More about Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England.

Remote control healing for osteoarthritis repair (2022)
Thesis
Echevarria, I. (2022). Remote control healing for osteoarthritis repair. (Thesis). Keele University

Articular cartilage is a key tissue for the normal functioning of the joints, with a trend for degradation with aging and physical activity. The lack of vascularisation hinders the self-repair, and often a scar tissue replaces the damaged cartilage,... Read More about Remote control healing for osteoarthritis repair.

Determining the role of epigenetics in telomerase regulation (2022)
Thesis
Dogan, F. (2022). Determining the role of epigenetics in telomerase regulation. (Thesis). Keele University

Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization. Telomerase macromolecule is the primary enzyme responsible for telomere elongation. Telom... Read More about Determining the role of epigenetics in telomerase regulation.

Phenotypic characterization of regional human meniscus progenitor cells. (2022)
Journal Article
(2022). Phenotypic characterization of regional human meniscus progenitor cells. Frontiers in Bioengineering and Biotechnology, 1003966 - ?. https://doi.org/10.3389/fbioe.2022.1003966

Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues. In... Read More about Phenotypic characterization of regional human meniscus progenitor cells..

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation (2022)
Journal Article
Mottershead. (2022). Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation. https://doi.org/10.22074/CELLJ.2022.8155

Objective: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation.