Plasmodium falciparum (2017)
Journal Article
(2017). Plasmodium falciparum. Emerging Topics in Life Sciences, 517-523. https://doi.org/10.1042/ETLS20170099

Plasmodium falciparum is a protozoan parasite that causes the most severe form of human malaria. Five other Plasmodium species can also infect humans — P. vivax, P. malariae, P. ovale curtisi, P. ovale wallikeri and P. knowlesi — but P. falciparum is... Read More about Plasmodium falciparum.

Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover (2017)
Journal Article
Channon. (2017). Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover. Scientific reports, https://doi.org/10.1038/s41598-017-14628-x

The critical mutation rate (CMR) determines the shift between survival-of-the-fittest and survival of individuals with greater mutational robustness (“flattest”). We identify an inverse relationship between CMR and sequence length in an in silico sys... Read More about Critical Mutation Rate has an Exponential Dependence on Population Size for Eukaryotic-length Genomes with Crossover.

In vivo analysis of the Escherichia coli ultrastructure by small-angle scattering (2017)
Journal Article
(2017). In vivo analysis of the Escherichia coli ultrastructure by small-angle scattering. IUCrJ, 751 -757. https://doi.org/10.1107/S2052252517013008

The flagellated Gram-negative bacterium Escherichia coli is one of the most studied microorganisms. Despite extensive studies as a model prokaryotic cell, the ultrastructure of the cell envelope at the nanometre scale has not been fully elucidated. H... Read More about In vivo analysis of the Escherichia coli ultrastructure by small-angle scattering.

Analysis of XFEL serial diffraction data from individual crystalline fibrils (2017)
Journal Article
(2017). Analysis of XFEL serial diffraction data from individual crystalline fibrils. IUCrJ, 795 -811. https://doi.org/10.1107/S2052252517014324

Serial diffraction data collected at the Linac Coherent Light Source from crystalline amyloid fibrils delivered in a liquid jet show that the fibrils are well oriented in the jet. At low fibril concentrations, diffraction patterns are recorded from s... Read More about Analysis of XFEL serial diffraction data from individual crystalline fibrils.

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence (2017)
Journal Article
Skidmore, M., Mohd Fadzli Mustaffa, K., Cooper, L. C., Guimond, S. E., Yates, E. A., & Craig, A. G. (2017). A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence. PloS one, 12(10), Article e0186276. https://doi.org/10.1371/journal.pone.0186276

A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the parasite-derived surface protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).... Read More about A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence.

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells (2017)
Journal Article
Ghezzi, S., Cooper, L., Rubio, A., Pagani, I., Rosaria Capobianchi, M., Ippolito, G., Pelletier, J., Meneghetti, M. C. Z., Lima, M. A., Skidmore, M., Broccoli, V., Yates, E. A., & Vicenzi, E. (2017). Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Research, 140, 13-17. https://doi.org/10.1016/j.antiviral.2016.12.023

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to tr... Read More about Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells.