Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells. (2015)
Journal Article
(2015). Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells. Frontiers in Cellular Neuroscience, 130 - ?. https://doi.org/10.3389/fncel.2015.00130

Loud sound exposure exacerbates aminoglycoside ototoxicity, increasing the risk of permanent hearing loss and degrading the quality of life in affected individuals. We previously reported that loud sound exposure induces temporary threshold shifts (T... Read More about Local mechanisms for loud sound-enhanced aminoglycoside entry into outer hair cells..

Targeting male mosquito mating behaviour for malaria control (2015)
Journal Article
(2015). Targeting male mosquito mating behaviour for malaria control. Parasites and Vectors, 347. https://doi.org/10.1186/s13071-015-0961-8

Malaria vector control relies heavily on the use of Long-Lasting Insecticidal Nets (LLINs) and Indoor Residual Spraying (IRS). These, together with the combined drug administration efforts to control malaria, have reduced the death toll to less than... Read More about Targeting male mosquito mating behaviour for malaria control.

Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function. (2014)
Journal Article
(2014). Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function. Journal of proteome research, 5120 - 5135. https://doi.org/10.1021/pr500556d

Viral pathogenesis in the infected cell is a balance between antiviral responses and subversion of host-cell processes. Many viral proteins specifically interact with host-cell proteins to promote virus biology. Understanding these interactions can l... Read More about Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function..

Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins. (2014)
Journal Article
(2014). Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins. PloS one, e103821 -?. https://doi.org/10.1371/journal.pone.0103821

The invasion of Theileria sporozoites into bovine leukocytes is rapidly followed by the destruction of the surrounding host cell membrane, allowing the parasite to establish its niche within the host cell cytoplasm. Theileria infection induces host c... Read More about Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins..

Draft Genome Sequence of "Candidatus Cronobacter colletis" NCTC 14934T, a New Species in the Genus Cronobacter (2014)
Journal Article
Masood. (2014). Draft Genome Sequence of "Candidatus Cronobacter colletis" NCTC 14934T, a New Species in the Genus Cronobacter. Genome Announcements,

Members of the Cronobacter genus are associated with serious infections in neonates. This is the first report of the draft genome sequence for the newly proposed species Cronobacter colletis.

Biting by Anopheles funestus in broad daylight after use of long-lasting insecticidal nets: a new challenge to malaria elimination. (2014)
Journal Article
(2014). Biting by Anopheles funestus in broad daylight after use of long-lasting insecticidal nets: a new challenge to malaria elimination. Malaria Journal, -. https://doi.org/10.1186/1475-2875-13-125

BACKGROUND: Malaria control is mainly based on indoor residual spraying and insecticide-treated bed nets. The efficacy of these tools depends on the behaviour of mosquitoes, which varies by species. With resistance to insecticides, mosquitoes adapt t... Read More about Biting by Anopheles funestus in broad daylight after use of long-lasting insecticidal nets: a new challenge to malaria elimination..

Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension (2014)
Journal Article
Harris, L. E., Morgan, D. G., & Balthasar, N. (2014). Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension. Physiological Reports, 2(3), e00240-?. https://doi.org/10.1002/phy2.240

Growth hormone secretagogue receptor (GHS-R) signaling has been associated with growth hormone release, increases in food intake and pleiotropic cardiovascular effects. Recent data demonstrated that acute GHS-R antagonism leads to increases in mean a... Read More about Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension.

"Wrong, but useful": negotiating uncertainty in infectious disease modelling. (2013)
Journal Article
(2013). "Wrong, but useful": negotiating uncertainty in infectious disease modelling. PloS one, e76277 - ?. https://doi.org/10.1371/journal.pone.0076277

For infectious disease dynamical models to inform policy for containment of infectious diseases the models must be able to predict; however, it is well recognised that such prediction will never be perfect. Nevertheless, the consensus is that althoug... Read More about "Wrong, but useful": negotiating uncertainty in infectious disease modelling..

The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels (2013)
Journal Article
(2013). The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels. Journal of General Physiology, 493 -505. https://doi.org/10.1085/jgp.201311068

Sound stimuli elicit movement of the stereocilia that make up the hair bundle of cochlear hair cells, putting tension on the tip links connecting the stereocilia and thereby opening mechanotransducer (MT) channels. Tmc1 and Tmc2, two members of the t... Read More about The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels.

Draft Genome Sequence of a Meningitic Isolate of Cronobacter sakazakii Clonal Complex 4, Strain 8399 (2013)
Journal Article
(2013). Draft Genome Sequence of a Meningitic Isolate of Cronobacter sakazakii Clonal Complex 4, Strain 8399. Genome Announcements, https://doi.org/10.1128/genomeA.00833-13

The Cronobacter sakazakii clonal lineage defined as clonal complex 4 (CC4), composed of nine sequence types, is associated with
severe cases of neonatal meningitis. To date, only closely related C. sakazakii sequence type 4 (ST4) strains have been s... Read More about Draft Genome Sequence of a Meningitic Isolate of Cronobacter sakazakii Clonal Complex 4, Strain 8399.

Imaging African trypanosomes (2013)
Journal Article
MacLean, L., Myburgh, E., Rodgers, J., & Price, H. (2013). Imaging African trypanosomes. Parasite immunology, 35(9-10), 283 -294. https://doi.org/10.1111/pim.12046

Trypanosoma brucei are extracellular kinetoplastid parasites transmitted by the blood-sucking tsetse fly. They are responsible for the fatal disease human African trypanosomiasis (HAT), also known as sleeping sickness. In late-stage infection, trypan... Read More about Imaging African trypanosomes.

Sialic acid utilization by Cronobacter sakazakii (2013)
Journal Article
Masood. (2013). Sialic acid utilization by Cronobacter sakazakii. Microbial Informatics and Experimentation, 3 - 3. https://doi.org/10.1186/2042-5783-3-3

Background
The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis a... Read More about Sialic acid utilization by Cronobacter sakazakii.

Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites. (2012)
Journal Article
Wastling. (2012). Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites. Nucleic acids research, D706 -D713. https://doi.org/10.1093/nar/gks1139

The Library of Apicomplexan Metabolic Pathways (LAMP, http://www.llamp.net) is a web database that provides near complete mapping from genes to the central metabolic functions for some of the prominent intracellular parasites of the phylum Apicomplex... Read More about Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites..

Structural and functional analysis of the symmetrical Type I restriction endonuclease R.EcoR124I(NT) (2012)
Journal Article
(2012). Structural and functional analysis of the symmetrical Type I restriction endonuclease R.EcoR124I(NT). PloS one, e35263 -?. https://doi.org/10.1371/journal.pone.0035263

Type I restriction-modification (RM) systems are comprised of two multi-subunit enzymes, the methyltransferase (~160 kDa), responsible for methylation of DNA, and the restriction endonuclease (~400 kDa), responsible for DNA cleavage. Both enzymes sha... Read More about Structural and functional analysis of the symmetrical Type I restriction endonuclease R.EcoR124I(NT).

Identification of novel proteins in Neospora caninum using an organelle purification and monoclonal antibody approach (2011)
Journal Article
(2011). Identification of novel proteins in Neospora caninum using an organelle purification and monoclonal antibody approach. PloS one, e18383 -?. https://doi.org/10.1371/journal.pone.0018383

Neospora caninum is an important veterinary pathogen that causes abortion in cattle and neuromuscular disease in dogs. Neospora has also generated substantial interest because it is an extremely close relative of the human pathogen Toxoplasma gondii,... Read More about Identification of novel proteins in Neospora caninum using an organelle purification and monoclonal antibody approach.

A DIGE study on the effects of salbutamol on the rat muscle proteome - an exemplar of best practice for data sharing in proteomics. (2011)
Journal Article
(2011). A DIGE study on the effects of salbutamol on the rat muscle proteome - an exemplar of best practice for data sharing in proteomics. BMC Research Notes, 86 -?. https://doi.org/10.1186/1756-0500-4-86

BACKGROUND: Proteomic techniques allow researchers to perform detailed analyses of cellular states and many studies are published each year, which highlight large numbers of proteins quantified in different samples. However, currently few data sets m... Read More about A DIGE study on the effects of salbutamol on the rat muscle proteome - an exemplar of best practice for data sharing in proteomics..

MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice (2009)
Journal Article
(2009). MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. PLOS genetics, e1000482 -?. https://doi.org/10.1371/journal.pgen.1000482

Myotonic dystrophy type 1 (DM1) is associated with one of the most highly unstable CTG*CAG repeat expansions. The formation of further repeat expansions in transgenic mice carrying expanded CTG*CAG tracts requires the mismatch repair (MMR) proteins M... Read More about MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.

Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features (2008)
Journal Article
(2008). Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. PloS one, e3968 -?. https://doi.org/10.1371/journal.pone.0003968

The genetic basis of myotonic dystrophy type I (DM1) is the expansion of a CTG tract located in the 3' untranslated region of DMPK. Expression of mutant RNAs encoding expanded CUG repeats plays a central role in the development of cardiac disease in... Read More about Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features.

Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human (2008)
Journal Article
(2008). Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. PloS one, e2934 -?. https://doi.org/10.1371/journal.pone.0002934

Mesenchymal stem cells (MSCs) are non-haematopoeitic, stromal cells that are capable of differentiating into mesenchymal tissues such as bone and cartilage. They are rare in bone marrow, but have the ability to expand many-fold in culture, and retain... Read More about Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human.

The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation. (2008)
Journal Article
(2008). The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation. Genome Biology, R116 - ?. https://doi.org/10.1186/gb-2008-9-7-r116

BACKGROUND: Although the genomes of many of the most important human and animal pathogens have now been sequenced, our understanding of the actual proteins expressed by these genomes and how well they predict protein sequence and expression is still... Read More about The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation..