A comparison of self-reported and device measured sedentary behaviour in adults: a systematic review and meta-analysis (2020)
Journal Article
Buckley, J. P., Prince, S. A., Cardilli, L., Reed, J. L., Saunders, T. J., Kite, C., Douillette, K., & Fournier, K. (2020). A comparison of self-reported and device measured sedentary behaviour in adults: a systematic review and meta-analysis. International Journal of Behavioral Nutrition and Physical Activity, 17(1), Article ARTN 31. https://doi.org/10.1186/s12966-020-00938-3

BACKGROUND: Sedentary behaviour (SB) is a risk factor for chronic disease and premature mortality. While many individual studies have examined the reliability and validity of various self-report measures for assessing SB, it is not clear, in general,... Read More about A comparison of self-reported and device measured sedentary behaviour in adults: a systematic review and meta-analysis.

Telescopic otology referrals: Evaluation of feasibility and acceptability. (2020)
Journal Article
(2020). Telescopic otology referrals: Evaluation of feasibility and acceptability. Laryngoscope Investigative Otolaryngology, 221 - 227. https://doi.org/10.1002/lio2.367

Objective: A remote telemedical otology referral and advice service was introduced to interested general practices. General practitioners (GPs) were given a new device, "endoscope-i" that combines an optimized smartphone high definition video app wit... Read More about Telescopic otology referrals: Evaluation of feasibility and acceptability..

Is Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic. Lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future (2020)
Journal Article
Kapata, N., Ihekweazu, C., Ntoumi, F., Raji, T., Chanda-Kapata, P., Mwaba, P., Mukonka, V., Bates, M., Tembo, J., Corman, V., Mfinanga, S., Asogun, D., Elton, L., Arruda, L., Thomason, M., Mboera, L., Yavlinsky, A., Haider, N., Simons, D., Hollmann, L., …Zumla, A. (2020). Is Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic. Lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future. International Journal of Infectious Diseases, 93, 233 - 236. https://doi.org/10.1016/j.ijid.2020.02.049

Multiple unplanned readmissions after discharge for an admission with percutaneous coronary intervention (2020)
Journal Article
Mamas, Kwok, C. S., Chatterjee, S., Bagur, R., Sharma, K., Alraies, M. C., Fischman, D., Savage, M., Mohamed, M., Shoaib, A., Patel, T., & Mamas, M. A. (2021). Multiple unplanned readmissions after discharge for an admission with percutaneous coronary intervention. Catheterization and Cardiovascular Interventions, 97(3), 395-408. https://doi.org/10.1002/ccd.28797

Objective This study aims to describe temporal trends, characteristics, and clinical outcomes of patients with more than one unplanned readmission within 30 and 180 days aer admission with percutaneous coronary intervention (PCI). Background There is... Read More about Multiple unplanned readmissions after discharge for an admission with percutaneous coronary intervention.

Biomedical Applications of Wrinkling Polymers (2020)
Journal Article
Fu, Y., & Yang, Y. (2020). Biomedical Applications of Wrinkling Polymers. https://doi.org/10.21926/rpm.2001005

Advancements in surface engineering and material fabrication techniques have enabled the creation and replication of naturally occurring surface topographies or the extrapolation of natural patterns to become achievable targets. Polymers are used ext... Read More about Biomedical Applications of Wrinkling Polymers.

Passengers' destinations from China: low risk of Novel Coronavirus (2019-nCoV) transmission into Africa and South America (2020)
Journal Article
Haider, N., Yavlinsky, A., Simons, D., Yusuf Osman, A., Ntoumi, F., Zumla, A., & Kock, R. (2020). Passengers' destinations from China: low risk of Novel Coronavirus (2019-nCoV) transmission into Africa and South America. Epidemiology and Infection, 148, Article e41. https://doi.org/10.1017/s0950268820000424

Novel Coronavirus (2019-nCoV [SARS-COV-2]) was detected in humans during the last week of December 2019 at Wuhan city in China, and caused 24 554 cases in 27 countries and territories as of 5 February 2020. The objective of this study was to estimate... Read More about Passengers' destinations from China: low risk of Novel Coronavirus (2019-nCoV) transmission into Africa and South America.

Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex (2020)
Journal Article
Viana, G. M., Gonzalez, E. A., Palacio Alvarez, M. M., Cavalheiro, R. P., do Nascimento, C. C., Baldo, G., D’Almeida, V., Andrade De Lima, M., Pshezhetsky, A., & Nader, H. B. (2020). Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex. International Journal of Molecular Sciences, 21, https://doi.org/10.3390/ijms21041459

Mucopolysaccharidosis type I (MPS I) is caused by genetic deficiency of alpha-l-iduronidase and impairment of lysosomal catabolism of heparan sulfate and dermatan sulfate. In the brain, these substrates accumulate in the lysosomes of neurons and glia... Read More about Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex.

Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial (2020)
Journal Article
Hill, J., Garvin, S., Chen, Y., Cooper, V., Wathall, S., Saunders, B., Lewis, A. M., Protheroe, J., Chudyk, A., Dunn, K., Hay, E., Van Der Windt, D., Mallen, C., & Foster, N. E. (2020). Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial. BMC Family Practice, 21, Article 30. https://doi.org/10.1186/s12875-019-1074-9

Background: Musculoskeletal (MSK) pain from the five most common presentations to primary care (back, neck, shoulder, knee or multi-site pain), where the majority of patients are managed, is a costly global health challenge. At present, first-line de... Read More about Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial.

The impact of the enhanced recovery pathway and other factors on outcomes and costs following hip and knee replacement: routine data study (2020)
Journal Article
(2020). The impact of the enhanced recovery pathway and other factors on outcomes and costs following hip and knee replacement: routine data study. Health Services and Delivery Research, https://doi.org/10.3310/hsdr08040

BACKGROUND:There is limited evidence concerning the effectiveness of enhanced recovery programmes in hip and knee replacement surgery, particularly when applied nationwide across a health-care system. OBJECTIVES:To determine the effect of hospital or... Read More about The impact of the enhanced recovery pathway and other factors on outcomes and costs following hip and knee replacement: routine data study.

Intravascular imaging and 12-month mortality after unprotected left main stem PCI: an analysis of 11,624 cases from British Cardiovascular Intervention Society database (2020)
Journal Article
Mamas. (2020). Intravascular imaging and 12-month mortality after unprotected left main stem PCI: an analysis of 11,624 cases from British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 346-357. https://doi.org/10.1016/j.jcin.2019.10.007

Background: Limited registry data supports the use of intravascular imaging during unprotected left main-stem PCI (uLMS-PCI) to improve outcomes. We used the BCIS national PCI database to explore temporal changes in the use of intravascular imaging f... Read More about Intravascular imaging and 12-month mortality after unprotected left main stem PCI: an analysis of 11,624 cases from British Cardiovascular Intervention Society database.

Developing a core outcome set for children with protracted bacterial bronchitis. (2020)
Journal Article
Gilchrist. (2020). Developing a core outcome set for children with protracted bacterial bronchitis. ERJ Open Research, https://doi.org/10.1183/23120541.00344-2019

Background: Protracted bacterial bronchitis (PBB) is a chronic endobrochial infection and a leading cause of chronic wet cough in children. There is an urgent need for a randomised controlled trial to investigate the optimal treatment but there is no... Read More about Developing a core outcome set for children with protracted bacterial bronchitis..

ACTN3's R577X Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players according to Their Field Position. (2020)
Journal Article
(2020). ACTN3's R577X Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players according to Their Field Position. Medical Principles and Practice, 92 - 97. https://doi.org/10.1159/000509089

INTRODUCTION: Football is characterised by intermittent high-intensity efforts varying according to the field position of a player. We aimed to ascertain whether polymorphisms in the ACTN3 gene are associated with different playing positions in elite... Read More about ACTN3's R577X Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players according to Their Field Position..

Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study. (2020)
Journal Article
Pan, S., Tsakok, T., Dand, N., Lonsdale, D. O., Loeff, F. C., Bloem, K., de Vries, A., Baudry, D., Duckworth, M., Mahil, S., Pushpa-Rajah, A., Russell, A., Alsharqi, A., Becher, G., Murphy, R., Wahie, S., Wright, A., Griffiths, C. E., Reynolds, N. J., Barker, J., …Study Group, B. (2020). Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study. Clinical and Translational Science, 13(2), 400 - 409. https://doi.org/10.1111/cts.12725

Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line... Read More about Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study..

International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis (2020)
Journal Article
Brown, E. A., Blake, P. G., Boudville, N., Davies, S., de Arteaga, J., Dong, J., Finkelstein, F., Foo, M., Hurst, H., Johnson, D. W., Johnson, M., Liew, A., Moraes, T., Perl, J., Shroff, R., Teitelbaum, I., Wang, A. Y.-M., & Warady, B. (2020). International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 40(3), 244- 253. https://doi.org/10.1177/0896860819895364

The International Society for Peritoneal Dialysis last published a guideline on prescribing peritoneal dialysis (PD) in 2006. This focused on clearance of toxins and used a measure of waste product removal by dialysis using urea as an example. This g... Read More about International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis.

Comparing the influence of ‘describing findings to the examiner’ or ‘examining as in usual practice’ on the students’ performance and assessors’ judgements during physical examination skills assessment (2020)
Journal Article
Stephenson, C., Yeates, P., & Lefroy, J. (2020). Comparing the influence of ‘describing findings to the examiner’ or ‘examining as in usual practice’ on the students’ performance and assessors’ judgements during physical examination skills assessment. MedEdPublish, 9(18), https://doi.org/10.15694/mep.2020.000018.1

Background:

Within assessment of physical examination skills, two approaches are common: “Describing Findings” (students comment throughout); and examining as “Usual Practice” (students only report findings at the end). Despite numerous potential... Read More about Comparing the influence of ‘describing findings to the examiner’ or ‘examining as in usual practice’ on the students’ performance and assessors’ judgements during physical examination skills assessment.

Scoliosis in paediatric onset spinal cord injuries. (2020)
Journal Article
Kuiper. (2020). Scoliosis in paediatric onset spinal cord injuries. Spinal Cord, https://doi.org/10.1038/s41393-020-0418-6

STUDY DESIGN: This is a retrospective longitudinal review. OBJECTIVE: The purpose of this review was to identify predictors of developing clinical scoliosis and compare between traumatic and neurological aetiologies of SCI. SETTING: This study was co... Read More about Scoliosis in paediatric onset spinal cord injuries..

Accuracy of the estimation of V and the implications this has when applying Kt/Vurea for measuring dialysis dose in peritoneal dialysis (2020)
Journal Article
Davies, S., & Finkelstein, F. O. (2020). Accuracy of the estimation of V and the implications this has when applying Kt/Vurea for measuring dialysis dose in peritoneal dialysis. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 40(3), 261 - 269. https://doi.org/10.1177/0896860819893817

BACKGROUND: Current guidelines for the prescription of peritoneal dialysis dose rely on a single cut-off 'minimal' value of Kt/V. To apply this in the clinic, this requires an accurate estimation of V, the volume of urea distribution that equates to... Read More about Accuracy of the estimation of V and the implications this has when applying Kt/Vurea for measuring dialysis dose in peritoneal dialysis.

Unplanned hospital readmissions after acute myocardial infarction: A nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014 (2020)
Journal Article
Capers I, Q., Fischmann, D., Kwok, C., Savage, M., Gulati, M., Potts, J., Mohamed, M., Nagaraja, V., Patwala, A., Heatlie, G., Kontopantelis, E., & Mamas, M. (2020). Unplanned hospital readmissions after acute myocardial infarction: A nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014. Coronary Artery Disease, 354-364. https://doi.org/10.1097/MCA.0000000000000844

Background
Unplanned hospital readmissions are an important quality metric for benchmarking but there is limited data following an acute myocardial infarction (AMI). This study aims to examine the 30-day unplanned readmission rate, predictors, cause... Read More about Unplanned hospital readmissions after acute myocardial infarction: A nationwide analysis of rates, trends, predictors and causes in the United States between 2010 and 2014.

Management Strategies and Clinical Outcomes of Acute Myocardial Infarction in Leukemia Patients: Insights from Nationwide United States Hospitalizations. (2020)
Journal Article
Mohamed, M., Lopez-Mattei, J., Iliesc, C., Parwani, P., Bharadwaj, A., Kim, P., Palaskas, N., Rashid, M., Potts, J., Rashid, M., Kwok, C., Gulati, M., Al Zubaidi, A., & Mamas, M. (2020). Management Strategies and Clinical Outcomes of Acute Myocardial Infarction in Leukemia Patients: Insights from Nationwide United States Hospitalizations. International Journal of Clinical Practice, -. https://doi.org/10.1111/ijcp.13476

BACKGROUND: Patients with leukemia are at increased risk of cardiovascular events. There are limited outcomes data for patients with a history of leukemia who present with an acute myocardial infarction (AMI). METHODS: We queried the Nationwide Inpat... Read More about Management Strategies and Clinical Outcomes of Acute Myocardial Infarction in Leukemia Patients: Insights from Nationwide United States Hospitalizations..

Spacers and Valved Holding Chambers—The Risk of Switching to Different Chambers (2020)
Journal Article
(2020). Spacers and Valved Holding Chambers—The Risk of Switching to Different Chambers. Journal of allergy and clinical immunology in practice, 1569 - 1573. https://doi.org/10.1016/j.jaip.2019.12.035

Spacers are pressurized metered-dose inhaler (pMDI) accessory devices developed to reduce problems of poor inhaler technique with pMDIs. Spacers that feature a 1-way inspiratory valve are termed valved holding chambers (VHCs); they act as aerosol res... Read More about Spacers and Valved Holding Chambers—The Risk of Switching to Different Chambers.