Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer. (2020)
Journal Article
Wragg, N. (2020). Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms21228579

Mesenchymal stem cells (MSCs) can differentiate into multiple different tissue lineages and have favourable immunogenic potential making them an attractive prospect for regenerative medicine. As an essential part of the manufacturing process, preserv... Read More about Cryopreservation of Mesenchymal Stem Cells Using Medical Grade Ice Nucleation Inducer..

Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. (2019)
Journal Article
Wragg, N. (2019). Systematic Review of miRNA as Biomarkers in Alzheimer's Disease. Molecular Neurobiology, 6156 - 6167. https://doi.org/10.1007/s12035-019-1500-y

Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of amyloid-beta plaques and hyperphosphorylated tau in the brain causing a... Read More about Systematic Review of miRNA as Biomarkers in Alzheimer's Disease..

Development of tissue-engineered skeletal muscle manufacturing variables. (2019)
Journal Article
Wragg, N. (2019). Development of tissue-engineered skeletal muscle manufacturing variables. Biotechnology and Bioengineering, 2364 - 2376. https://doi.org/10.1002/bit.27074

Three-dimensional tissue-engineered structures enable more representative determination of novel drug or material effects on tissue than traditional monolayer cell cultures. This study sought to better understand how key manufacturing variables affec... Read More about Development of tissue-engineered skeletal muscle manufacturing variables..

A critical review of current progress in 3D kidney biomanufacturing: advances, challenges, and recommendations (2019)
Journal Article
Wragg, N., Burke, L., & Wilson, S. L. (2019). A critical review of current progress in 3D kidney biomanufacturing: advances, challenges, and recommendations. Renal Replacement Therapy, 5, Article 18. https://doi.org/10.1186/s41100-019-0218-7

The widening gap between organ availability and need is resulting in a worldwide crisis, particularly concerning kidney transplantation. Regenerative medicine options are becoming increasingly advanced and are taking advantage of progress in novel ma... Read More about A critical review of current progress in 3D kidney biomanufacturing: advances, challenges, and recommendations.