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Patella resurfacing during total knee arthroplasty is cost-effective and has lower re-operation rates compared to non-resurfacing. (2021)
Journal Article
(2021). Patella resurfacing during total knee arthroplasty is cost-effective and has lower re-operation rates compared to non-resurfacing. Journal of Orthopaedic Surgery and Research, 185 - ?. https://doi.org/10.1186/s13018-021-02295-8

BACKGROUND: The decision to resurface the patella as part of total knee arthroplasty may be influenced by the surgeon's preference, education, training, tradition and geographic location. Advocates for non-resurfacing or selectively resurfacing may c... Read More about Patella resurfacing during total knee arthroplasty is cost-effective and has lower re-operation rates compared to non-resurfacing..

Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity (2021)
Journal Article
Kuiper. (2021). Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity. BONE, https://doi.org/10.1016/j.bone.2020.115769

It is well founded that the mechanical environment may regulate bone regeneration in orthopedic applications. The purpose of this study is to investigate the mechanical contributions of the scaffold and the host to bone regeneration, in terms of subj... Read More about Mechano-driven regeneration predicts response variations in large animal model based on scaffold implantation site and individual mechano-sensitivity.

Autologous Matrix-Induced Chondrogenesis (AMIC) and Microfractures for Focal Chondral Defects of the Knee: A Medium-Term Comparative Study (2021)
Journal Article
(2021). Autologous Matrix-Induced Chondrogenesis (AMIC) and Microfractures for Focal Chondral Defects of the Knee: A Medium-Term Comparative Study. Life, https://doi.org/10.3390/life11030183

INTRODUCTION: The potential of autologous matrix-induced chondrogenesis (AMIC) to restore unipolar focal chondral defects of the knee is promising. However, the outcome compared to microfracturing (MFx) for certain defect sizes (2-3 cm2) is still unc... Read More about Autologous Matrix-Induced Chondrogenesis (AMIC) and Microfractures for Focal Chondral Defects of the Knee: A Medium-Term Comparative Study.

Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury (2021)
Journal Article
Bahsoun, S., Kuiper, J.-H., Hulme, C., Twigg, A., El Masri, W., Glass, C., Soni, B., Kumar, N., Chowdhury, J., Osman, A., & Wright, K. (2021). Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury. Scientific reports, 11, Article 4361. https://doi.org/10.1038/s41598-021-83211-2

A questionnaire was developed to evaluate patients' perspective on research aimed at improving functions and overcoming complications associated with spinal cord injury (SCI). The first three sections were based on published and validated assessment... Read More about Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury.

Use and evaluation of assistive technologies for upper limb function in tetraplegia (2021)
Journal Article
Readioff, R., Kamran Siddiqui, Z., Stewart, C., Fulbrook, L., O’Connor, R. J., & Chadwick, E. K. (2021). Use and evaluation of assistive technologies for upper limb function in tetraplegia. Journal of Spinal Cord Medicine, 45(6), 1 - 12. https://doi.org/10.1080/10790268.2021.1878342

Context More than half of all spinal cord injuries (SCI) occur at the cervical level leading to loss of upper limb function, restricted activity and reduced independence. Several technologies have been developed to assist with upper limb functions in... Read More about Use and evaluation of assistive technologies for upper limb function in tetraplegia.

The use of hypnotherapy as treatment for functional stroke: A case series from a single center in the UK (2021)
Journal Article
Sanyal, R., Raseta, M., Natarajan, I., & Roffe, C. (2022). The use of hypnotherapy as treatment for functional stroke: A case series from a single center in the UK. International Journal of Stroke, 17(1), 59-66. https://doi.org/10.1177/1747493021995590

Background Functional neurological disorder is defined by symptoms not explained by the current model of disease and its pathophysiology. It is found in 8.4% of patients presenting as acute stroke. Treatment is difficult and recurrence rates are high... Read More about The use of hypnotherapy as treatment for functional stroke: A case series from a single center in the UK.

Asymptomatic Foot and Ankle Abnormalities in Elite Professional Soccer Players. (2021)
Journal Article
(2021). Asymptomatic Foot and Ankle Abnormalities in Elite Professional Soccer Players. Orthopaedic Journal of Sports Medicine, https://doi.org/10.1177/2325967120979994

Background: Professional soccer players are often evaluated with asymptomatic lesions of the ankle and foot, and such abnormalities may eventually become clinically relevant. Purpose: To ascertain the prevalence of foot and ankle abnormalities in eli... Read More about Asymptomatic Foot and Ankle Abnormalities in Elite Professional Soccer Players..

Impact of tourniquet during knee arthroplasty: a bayesian network meta-analysis of peri-operative outcomes. (2021)
Journal Article
(2021). Impact of tourniquet during knee arthroplasty: a bayesian network meta-analysis of peri-operative outcomes. Archives of Orthopaedic and Trauma Surgery, https://doi.org/10.1007/s00402-020-03725-8

INTRODUCTION: The role of tourniquet during knee arthroplasty is controversial. The present study compares various tourniquet protocols using a Bayesian network meta-analysis of peri-operative data.

MATERIAL AND METHODS: The present study was con... Read More about Impact of tourniquet during knee arthroplasty: a bayesian network meta-analysis of peri-operative outcomes..

The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures (2021)
Journal Article
Andersen, C., Wragg, N., Shariatzadeh, M., & Wilson, S. L. (2021). The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures. Current Osteoporosis Reports, 19, 1-14. https://doi.org/10.1007/s11914-020-00643-x

PURPOSE OF REVIEW: The treatment of non-union fractures represents a significant challenge for orthopaedic surgeons. In recent years, biologic agents have been investigated and utilised to support and improve bone healing. Among these agents, platele... Read More about The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures.

Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. (2020)
Journal Article
Gómez-Gálvez, Y., & Gates, M. (2020). Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons. Journal of Neuroscience Methods, 109065 - ?. https://doi.org/10.1016/j.jneumeth.2020.109065

BACKGROUND: Primary embryonic ventral mesencephalic (VM) cultures are a high throughput tool for understanding and manipulating dopamine neurons, to study the mechanisms that trigger their degeneration during Parkinson's disease (PD), and to test new... Read More about Paclitaxel is effective for controlling astrocyte proliferation in vitro: Implications for generating ventral mesencephalic cultures enriched with dopamine neurons..

Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues (2020)
Journal Article
Wang, J., Roberts, S., Kuiper, J., Zhang, W., Garcia, J., Cui, Z., & Wright, K. (2020). Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues. Scientific reports, 10, Article 21658. https://doi.org/10.1038/s41598-020-78757-6

Meniscus degeneration is closely related to the progression of knee osteoarthritis (OA). However, there is currently a lack of quantitative and objective metrics to assess OA meniscal cell phenotypes. In this study we investigated the phenotypic mark... Read More about Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues.

Periodization in Anterior Cruciate Ligament Rehabilitation: A Novel Framework (2020)
Journal Article
(2020). Periodization in Anterior Cruciate Ligament Rehabilitation: A Novel Framework. Medical Principles and Practice, 1 - 8. https://doi.org/10.1159/000511228

More than 250,000 anterior cruciate ligament (ACL) injuries occur each year in the USA, and approximately 65% of these injuries undergo reconstructive surgery. Appropriate rehabilitation after ACL reconstruction can yield predictably good outcomes, w... Read More about Periodization in Anterior Cruciate Ligament Rehabilitation: A Novel Framework.

Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo (2020)
Journal Article
Jones, F. K., Stefan, A., Kay, A. G., Hyland, M., Morgan, R., Forsyth, N. R., Pisconti, A., & Kehoe, O. (2020). Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo. Scientific reports, https://doi.org/10.1038/s41598-020-77514-z

Rheumatoid arthritis (RA) is a debilitating and painful inflammatory autoimmune disease characterised by the accumulation of leukocytes in the synovium, cartilage destruction and bone erosion. The immunomodulatory effects of bone marrow derived mesen... Read More about Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo.

A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN (2020)
Journal Article
Rademacher, S., Detering, N. . T., Schüning, T., Lindner, R., Santonicola, P., Wefel, I.-M., Dehus, J., Walter, L. M., Brinkmann, H., Niewienda, A., Janek, K., Varela, M. A., Bowerman, M., Di Schiavi, E., & Claus, P. (2020). A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN. Cells, 9(11), Article 2405. https://doi.org/10.3390/cells9112405

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms for regulation of its stability are still elusive. Thus, we aimed to identify regulatory ph... Read More about A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN.

Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress (2020)
Journal Article
Rummun, N., Pires, E., McCullagh, J., Claridge, T. W., Bahorun, T., Li, W., & Neergheen, V. S. (2021). Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress. South African Journal of Botany, 137, 149 - 158. https://doi.org/10.1016/j.sajb.2020.10.014

Whilst the pharmacological potential of Syzygium species is well reported in the literature, data on the Mauritian endemic Syzygium species is limited. Thus, the in vitro antioxidant and anti-proliferative properties of three endangered Syzygium spec... Read More about Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress.

Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases (2020)
Journal Article
Bowerman, M. (2020). Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases. Brain Sciences, 10(9), Article 633. https://doi.org/10.3390/brainsci10090633

Note: In lieu of an abstract, this is an excerpt from the first page.

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD), severely impact the function of neuronal cells in the brain... Read More about Recent Advances and Future Perspectives in the Development of Therapeutic Approaches for Neurodegenerative Diseases.

Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis (2020)
Other
Kay, A., Roach, P., Treadwell, K., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., Kehoe, O., & Forsyth, N. R. (2020). Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis

Abstract Background Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling via growth f... Read More about Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce Disease Severity and Immune Responses in Inflammatory Arthritis.

Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury (2020)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Osman, A., Roy Chowdhury, J., Kumar, N., Budithi, S., & Wright, K. (2020). Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury. Journal of Neurotrauma, 38(3), https://doi.org/10.1089/neu.2020.7144

Neurological outcomes following spinal cord injury (SCI) are currently difficult to predict. Whilst the initial American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade can give an estimate of outcome, the high remaining degree of uncer... Read More about Routinely Measured Hematological Markers Can Help to Predict American Spinal Injury Association Impairment Scale Scores after Spinal Cord Injury.