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Effect of Low Back Pain Risk-Stratification Strategy on Patient Outcomes and Care Processes: the MATCH Randomized Trial in Primary Care (2018)
Journal Article
Cherkin, D., Balderson, B., Wellman, R., Hsu, C., Sherman, K., Evers, S., Hawkes, R., Cook, A., Levine, M., Piekara, D., Rock, P., Estlin, K., Brewer, G., Jensen, M., LaPorte, A.-M., Yeoman, J., Sowden, G., Hill, J., & Foster, N. (2018). Effect of Low Back Pain Risk-Stratification Strategy on Patient Outcomes and Care Processes: the MATCH Randomized Trial in Primary Care. Journal of General Internal Medicine, 1324-1336. https://doi.org/10.1007/s11606-018-4468-9

BACKGROUND: The STarT Back strategy for categorizing and treating patients with low back pain (LBP) improved patients' function while reducing costs in England. OBJECTIVE: This trial evaluated the effect of implementing an adaptation of this approach... Read More about Effect of Low Back Pain Risk-Stratification Strategy on Patient Outcomes and Care Processes: the MATCH Randomized Trial in Primary Care.

Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial (2018)
Journal Article
Chew-Graham, C. (2018). Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial. British Journal of Psychiatry, 456-463. https://doi.org/10.1192/bjp.2018.70

Background
Collaborative care can support the treatment of depression in people with long-term conditions, but long-term benefits and costs are unknown.

Aims
To explore the long-term (24-month) effectiveness and cost-effectiveness of collaborati... Read More about Long-term clinical and cost-effectiveness of collaborative care (versus usual care) for people with mental–physical multimorbidity: cluster-randomised trial.

Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study. (2018)
Journal Article
(2018). Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study. Journal of Neurology, 265, 1795 - 1802. https://doi.org/10.1007/s00415-018-8903-y

Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary prog... Read More about Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study..

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC) (2018)
Journal Article
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., Foster, N. E., Walsh, D., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S., & Wilkinson, C. (2018). Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). Trials, 19, Article 408. https://doi.org/10.1186/s13063-018-2801-6

BACKGROUND: Adalimumab, a biological treatment targeting tumour necrosis factor a, might be useful in sciatica. This paper describes the challenges faced when developing a new treatment pathway for a randomised controlled trial of adalimumab for peop... Read More about Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

Effect of Comorbidity On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmission Database). (2018)
Journal Article
Kwok, C., Mamas, M., Martinez, S., Pancholy, S., Ahmed, W., Al-Shaibi, K., Potts, J., Mohamed, M., Kontopantelis, E., & Curzen, N. (2018). Effect of Comorbidity On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmission Database). Scientific reports, 11156 -?. https://doi.org/10.1038/s41598-018-29303-y

It is unclear how comorbidity influences rates and causes of unplanned readmissions following percutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database who were admitted to hospital between 2010 and 2014. T... Read More about Effect of Comorbidity On Unplanned Readmissions After Percutaneous Coronary Intervention (From The Nationwide Readmission Database)..

Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients (2018)
Journal Article
Yu. (2018). Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients. Kidney and Blood Pressure Research, https://doi.org/10.1159/000492048

Background/Aims:
Cerebrovascular disease (CeVD) is one of the leading causes of death in patients initialising peritoneal dialysis (PD). Currently there is no risk score to predict the future risk of CeVD on entry into PD. This study aimed to derive... Read More about Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients.

Justifications for using complementary and alternative medicine reported by persons with musculoskeletal conditions: A narrative literature synthesis (2018)
Journal Article
Corp, N., Jordan, J. L., & Croft, P. R. (2018). Justifications for using complementary and alternative medicine reported by persons with musculoskeletal conditions: A narrative literature synthesis. PloS one, 13(7), Article e0200879. https://doi.org/10.1371/journal.pone.0200879

BACKGROUND: Complementary and alternative medicine (CAM) is very popular with patients frequently combining it with orthodox health care. The high prevalence of CAM use and satisfaction with CAM reported by patients directly challenges an orthodox sy... Read More about Justifications for using complementary and alternative medicine reported by persons with musculoskeletal conditions: A narrative literature synthesis.

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., Evans, A., Holden, M., Stevenson, K., Menon, A., Bromley, K., Roberts, P., Hall, A., Peat, G., Jinks, C., Oppong, R., Lewis, M., Foster, N. E., Mallen, C., & Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.

Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States (2018)
Journal Article
Al Shaibi, K., Gulati, R., Bell, M., Anderson, V., Potts, J., Rashid, M., Kontopantelis, E., Bagur, R., Mamas, M., & Kwok, C. (2018). Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States. JACC. Cardiovascular interventions, 1354-1364. https://doi.org/10.1016/j.jcin.2018.03.049

Discharge against medical advice (DAMA) in the context of PCI has not been described in the literature. Among the 2,021,104 patients, the proportion of patients who DAMA was 0.5% (n=10,049). Important predictors of DAMA included diagnosis of acute my... Read More about Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States.

Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database) (2018)
Journal Article
Martinez, S., Rao, S., Gilchrist, I., Kwok, C., Al Ayoubi, F., Myint, P., Mamas, M., Potts, J., Rashid, M., & Kontopantelis, E. (2018). Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database). American Journal of Cardiology, 220-228. https://doi.org/10.1016/j.amjcard.2018.03.367

It is unclear how age affects rates and causes of unplanned early readmissions after per cutaneous coronary intervention (PCI). We analyzed patients in the Nationwide Readmission Database in the United States from 2010 to 2014 and examined the impact... Read More about Relation Between Age and Unplanned Readmissions After Percutaneous Coronary Intervention (Findings From The Nationwide Readmission Database).

The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes. (2018)
Journal Article
Ramachandran, S., Strange, R., Fryer, A., Saad, F., & Hackett, G. (2018). The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes. Andrology, 6(6), 846-853. https://doi.org/10.1111/andr.12520

BACKGROUND:
Serum sex hormone-binding globulin levels have been associated with mortality in adult men with type 2 diabetes (T2DM).

OBJECTIVES:
To confirm the association of serum sex hormone-binding globulin with mortality and then determine wh... Read More about The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes..

A mixed methods study to evaluate the feasibility of using the Adolescent Diabetes Needs Assessment Tool App in paediatric diabetes care in preparation for a longitudinal cohort study. (2018)
Journal Article
(2018). A mixed methods study to evaluate the feasibility of using the Adolescent Diabetes Needs Assessment Tool App in paediatric diabetes care in preparation for a longitudinal cohort study. Pilot and Feasibility Studies, 13 - ?. https://doi.org/10.1186/s40814-017-0164-5

BACKGROUND: An evaluation study was carried out to determine the feasibility of integrating the Adolescent Diabetes Needs Assessment Tool (ADNAT) App into UK paediatric diabetes care, to ascertain best practice standards and to determine methodologic... Read More about A mixed methods study to evaluate the feasibility of using the Adolescent Diabetes Needs Assessment Tool App in paediatric diabetes care in preparation for a longitudinal cohort study..

Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. (2018)
Journal Article
Mallen. (2018). Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. Pilot and Feasibility Studies, 93 - ?. https://doi.org/10.1186/s40814-018-0288-2

Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was to test the feasibility and e... Read More about Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care..

Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study (2018)
Journal Article
Mallen, Roddy, Bucknall, Muller, Hider, Helliwell, & Paskins. (2018). Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study. Osteoporosis International, 1659-1664. https://doi.org/10.1007/s00198-018-4491-z

This study aimed to examine fracture risk in patients with late-onset psoriasis. A cohort study was conducted using primary care records from the Clinical Practice Research Datalink. Psoriasis patients had a 10% increased risk of fracture compared to... Read More about Risk of fragility fracture among patients with late-onset psoriasis: a United Kingdom population-based study.

Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk? (2018)
Journal Article
Hider, S. (2018). Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk?. Drug Safety, https://doi.org/10.1007/s40264-018-0651-5

Two different Janus kinase (JAK) inhibitors-baricitinib and tofacitinib-are effective and licensed in active rheumatoid arthritis (RA). There have been recent concerns about potential thromboembolic risks with these drugs. Concerns about baricitinib... Read More about Thromboembolism with Janus Kinase (JAK) Inhibitors for Rheumatoid Arthritis: How Real is the Risk?.

Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design (2018)
Journal Article
Mamas, Chew-Graham, & Mallen. (2018). Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design. BMJ Open, https://doi.org/10.1136/bmjopen-2017-020926

Introduction: The increasing prevalence of type 2 diabetes (T2DM) presents a significant burden on affected individuals and health-care systems internationally. There is, however, no agreed validated measure to infer diabetes severity from electronic... Read More about Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design.

Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry (2018)
Journal Article
Mamas. (2018). Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry. Cardiovascular Medicine, https://doi.org/10.1136/bmjopen-2018-022543

Objectives
Previous studies indicate frailty to be associated with poor outcomes following transcatheter aortic valve implantation (TAVI), but there is limited evidence from multicentre registries. The aim was to investigate the independent associat... Read More about Do frailty measures improve prediction of mortality and morbidity following transcatheter aortic valve implantation? An analysis of the UK TAVI registry.

Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes (2018)
Thesis
Elttayef, A. A. J. Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411158

The islets of Langerhans are multicellular aggregates within the pancreas containing beta cells that sense changes in blood glucose level and respond by secreting insulin. The cells within the islets communicate with each other through gap junctions.... Read More about Generation and characterisation of tissue-engineered Pseudoislet models for the study of diabetes.

Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds. (2018)
Journal Article
Yang. (2018). Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds. Interface, https://doi.org/10.1098/rsif.2018.0310

Cartilage is anisotropic in nature and organized into distinct zones. Our goal was to develop zonal-specific three-dimensional hybrid scaffolds which could induce the generation of zonal-specific cellular morphology and extracellular matrix (ECM) com... Read More about Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds..