Wharton's jelly and osteoarthritis of the knee. (2023)
Journal Article
Aratikatla, A., Maffulli, N., Gupta, M., Potti, I. A., Potty, A. G., & Gupta, A. (in press). Wharton's jelly and osteoarthritis of the knee. British Medical Bulletin, https://doi.org/10.1093/bmb/ldad030

The existing treatment modalities for knee osteoarthritis (OA) do not actually address the pathology. Biological therapies, including those using material derived from perinatal tissues, represent a ground-breaking approach to alleviating the symptom... Read More about Wharton's jelly and osteoarthritis of the knee..

Demographic characteristics influencing the stem subsidence in total hip arthroplasty: an imaging study. (2023)
Journal Article
Migliorini, F., Maffulli, N., Pilone, M., Velaj, E., Hofmann, U. K., & Bell, A. (in press). Demographic characteristics influencing the stem subsidence in total hip arthroplasty: an imaging study. Archives of Orthopaedic and Trauma Surgery, https://doi.org/10.1007/s00402-023-05054-y

The present study evaluated whether patient demographic characteristics influence the subsidence of the stem in total hip arthroplasty (THA). The following characteristics were evaluated: age, height, weight, and sex. The association between the time... Read More about Demographic characteristics influencing the stem subsidence in total hip arthroplasty: an imaging study..

Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review (2023)
Journal Article
Migliorini, F., Maffulli, N., Pilone, M., Bell, A., Hildebrand, F., & Konrads, C. (in press). Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review. Scientific reports, 13(1), 15612. https://doi.org/10.1038/s41598-023-42809-4

Total hip arthroplasty (THA) is a successful orthopaedic surgical procedure, and its longevity depends on bearing components and implant fixation. Optimizing polyethylene and ceramics has led to improved wear parameters and contributed to improved lo... Read More about Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review.

Clinical Movement Analysis Society– UK and Ireland (2023)
Journal Article
Stewart, C., Eve, L., Durham, S., Holmes, G., Stebbins, J., Harrington, M., …Noble, J. (2023). Clinical Movement Analysis Society– UK and Ireland. Gait & Posture, 106, 86-94. https://doi.org/10.1016/j.gaitpost.2023.08.006

Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study (2023)
Journal Article
Mason, K. J., Jordan, K. P., Heron, N., Edwards, J. J., Bailey, J., Achana, F. A., …Marshall, M. (2023). Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study. Musculoskeletal Care, 21(3), 749-762. https://doi.org/10.1002/msc.1748

OBJECTIVE: Musculoskeletal painful conditions are a risk factor for cardiovascular disease (CVD), but less is known about whether musculoskeletal pain also worsens prognosis from CVD. The objective was to determine whether patients with musculoskelet... Read More about Musculoskeletal pain and its impact on prognosis following acute coronary syndrome or stroke: A linked electronic health record cohort study.

Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial (2022)
Journal Article
Roffe. (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.

Elderly Patients' Perspectives on the Acceptability of Deprescribing Medicines: A Qualitative Study Protocol (2022)
Journal Article
Channa, K. K., Venables, R., & White, S. (2022). Elderly Patients' Perspectives on the Acceptability of Deprescribing Medicines: A Qualitative Study Protocol. International Journal of Qualitative Methods, 21, https://doi.org/10.1177/16094069221116975

The ageing population has resulted in an increase in multimorbidity and polypharmacy, and subsequently the complexity of optimising elderly patients’ medicines. The need for deprescribing can arise from factors such as increased susceptibility to adv... Read More about Elderly Patients' Perspectives on the Acceptability of Deprescribing Medicines: A Qualitative Study Protocol.

Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics (2022)
Journal Article
Hu, B., Rotherham, M., Farrow, N., Roach, P., Dobson, J., & El Haj, A. J. (2022). Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics. International Journal of Molecular Sciences, 23(17), Article 10164. https://doi.org/10.3390/ijms231710164

Wnt signaling plays an important role in embryogenesis and adult stem cell homeostasis. Its diminished activation is implicated in osteoporosis and degenerative neural diseases. However, systematic administration of Wnt-signaling agonists carries ris... Read More about Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics.

Clot-Targeted Magnetic Hyperthermia Permeabilizes Blood Clots to Make Them More Susceptible to Thrombolysis (2022)
Journal Article
Cabrera, D., Sharifabad, M. E., Ranjbar, J. A., Telling, N. D., & Harper, A. G. (2022). Clot-Targeted Magnetic Hyperthermia Permeabilizes Blood Clots to Make Them More Susceptible to Thrombolysis. Journal of Thrombosis and Haemostasis, 20(11), https://doi.org/10.1111/jth.15846

BACKGROUND: Thrombolysis is a frontline treatment for stroke, which involves the application of tissue plasminogen activator (tPA) to trigger endogenous clot-degradation pathways.However, it is only effective within 4.5 hours of symptom onset due to... Read More about Clot-Targeted Magnetic Hyperthermia Permeabilizes Blood Clots to Make Them More Susceptible to Thrombolysis.

P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study (2022)
Journal Article
Mason, K. J., Jordan, K. P., Achana, F. A., Bailey, J., Chen, Y., Frisher, M., …Edwards, J. J. (2022). P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study. Rheumatology, 61(S1), https://doi.org/10.1093/rheumatology/keac133.180

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background/Aims</jats:title> <jats:p>There is some evidence of an increased risk of cardiovascular disease in patients with painful musculoskeletal conditions, but it is unclear if musculoskele... Read More about P181 Musculoskeletal pain and prognosis of acute coronary syndrome and cerebrovascular accident: a linked electronic health record cohort study.

In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. (2022)
Journal Article
Kaur Sandhu, A., Yang, Y., & Li, W. (2022). In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. ACS Biomaterials Science and Engineering, 1749-1762. https://doi.org/10.1021/acsbiomaterials.1c01307

Biomaterial-associated infection is difficult to detect and brings consequences that can lead to morbidity and mortality. Bacteria can adhere to the implant surface, grow, and form biofilms. Antimicrobial peptides (AMPs) can target and kill bacterial... Read More about In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis..

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties.

Ankle-foot orthosis adherence in children and adolescents with cerebral palsy: A scoping review (2022)
Journal Article
Faux-Nightingale, A., Kelemen, M., & Stewart, C. (2022). Ankle-foot orthosis adherence in children and adolescents with cerebral palsy: A scoping review. Prosthetics and Orthotics International, 46(4), 351-356. https://doi.org/10.1097/pxr.0000000000000095

Background: Ankle-foot orthoses (AFOs) are commonly supplied to children with cerebral palsy (CP) to support their gait. However, usage is reported to decrease through adolescence. Because AFOs can allow users to engage in daily activities and develo... Read More about Ankle-foot orthosis adherence in children and adolescents with cerebral palsy: A scoping review.

Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study (2022)
Journal Article
Abas, S., Kuiper, J. H., Roberts, S., McCarthy, H., Williams, M., Bing, A., …Makwana, N. (2022). Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study. Cells, 11(4), Article 629. https://doi.org/10.3390/cells11040629

Osteochondral defects of the ankle (OCD) are being increasingly identified as a clinically significant consequence of injury to the ankle, with the potential to lead to osteoarthritis if left untreated. The aim of this retrospective cohort study was... Read More about Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study.

The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) (2021)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., McLoughlin, K., Wong, L., …Heald, A. H. (2022). The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). https://doi.org/10.1002/edm2.302

BACKGROUND: Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG monitoring in people with type 1... Read More about The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM).

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device (2021)
Journal Article
Wragg, N. (2021). Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Molecular Therapy - Methods and Clinical Development, 551-566. https://doi.org/10.1016/j.omtm.2021.10.015

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir... Read More about Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device.

Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A systematic review and meta-analysis (2021)
Journal Article
(2021). Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A systematic review and meta-analysis. Journal of Clinical Neuroscience, 159 - 165. https://doi.org/10.1016/j.jocn.2021.10.017

Objective To assess the prognostic values of susceptibility vessel sign (SVS) on T2*-weighted MRI using GRE and SWI sequences for recanalization status and clinical outcomes in patients with acute ischaemic stroke undergoing different therapies. Meth... Read More about Susceptibility vessel sign as a predictor for recanalization and clinical outcome in acute ischaemic stroke: A systematic review and meta-analysis.

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. (2021)
Journal Article
Chen. (2021). Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. Alzheimer's Research and Therapy, 194 - ?. https://doi.org/10.1186/s13195-021-00935-z

BACKGROUND: Alzheimer's disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IH... Read More about Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain..

Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT (2021)
Journal Article
Adab, P., Jordan, R. E., Fitzmaurice, D., Ayres, J. G., Cheng, K., Cooper, B. G., …Turner, A. (2021). Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT. Programme Grants for Applied Research, 9(13), 1 - 148. https://doi.org/10.3310/pgfar09130

BackgroundChronic obstructive pulmonary disease is a major contributor to morbidity, mortality and health service costs but is vastly underdiagnosed. Evidence on screening and how best to approach this is not clear. There are also uncertainties aroun... Read More about Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT.