Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion (2022)
Journal Article
Wong, A. M., Ding, X., Wong, A. M., Xu, M., Zhang, L., Leung, H. H.-W., Chan, A. W.-H., Song, Q. X., Kwong, J., Chan, L. K.-Y., Man, M., He, M., Chen, J., Zhang, Z., You, W., Lau, C., Yu, A., Wei, Y., Yuan, Y., Lai, P. B.-S., …Wong, N. (2022). Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion. Journal of Hepatology, 77(2), 410-423. https://doi.org/10.1016/j.jhep.2022.03.015

Background & Aims
Metabolic syndrome can lead to the clinical manifestation of non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) as part of the natural history of NAFLD. Despite a strong causative link, NAFLD-HCC is often... Read More about Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion.

Short-Form Thymic Stromal Lymphopoietin (sfTSLP) Is the Predominant Isoform Expressed by Gynaecologic Cancers and Promotes Tumour Growth (2021)
Journal Article
Kwong, J. (2021). Short-Form Thymic Stromal Lymphopoietin (sfTSLP) Is the Predominant Isoform Expressed by Gynaecologic Cancers and Promotes Tumour Growth. Cancers,

Thymic stromal lymphopoietin (TSLP) is an epithelial cell derived cytokine belonging to the IL-7 family and a key initiator of allergic inflammation. Two main isoforms of TSLP, classified as long- (lfTSLP) and short-form (sfTSLP), have been reported... Read More about Short-Form Thymic Stromal Lymphopoietin (sfTSLP) Is the Predominant Isoform Expressed by Gynaecologic Cancers and Promotes Tumour Growth.

Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer (2020)
Journal Article
kwong, J. (2020). Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer. BMC Cancer, https://doi.org/10.1186/s12885-020-07455-3

Abstract

Background
Previous studies have shown a major green tea polyphenol (-)-epigallocatechin-3-gallate ((-)-EGCG) as a powerful anti-cancer agent. However, its poor bioavailability and requirement of a high dosage to manifest activity have... Read More about Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer.

Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system. (2018)
Journal Article
Kwong, J. (2018). Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system. Journal of Ovarian Research, 36 - ?. https://doi.org/10.1186/s13048-018-0403-2

BACKGROUND: Ovarian cancer stem cells (OCSCs) contribute to the poor prognosis of ovarian cancer. Involvement of the androgen receptor (AR) in the malignant behaviors of other tumors has been reported. However, whether AR associates with Nanog (a ste... Read More about Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system..

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. (2017)
Journal Article
Kwong, J. (2017). A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. Oncogene, 3576 - 3587. https://doi.org/10.1038/onc.2016.509

Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts... Read More about A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR..