Calcification Microstructure Reflects Breast Tissue Microenvironment (2019)
Journal Article
Gosling, S., Scott, R., Greenwood, C., Bouzy, P., Nallala, J., D. Lyburn, I., Stone, N., & Rogers, K. (2019). Calcification Microstructure Reflects Breast Tissue Microenvironment. Journal of Mammary Gland Biology and Neoplasia, 333-342. https://doi.org/10.1007/s10911-019-09441-3

Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. Hydroxyapatite microcalcific... Read More about Calcification Microstructure Reflects Breast Tissue Microenvironment.

Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening (2019)
Journal Article
Jinsakul, N., Tsai, C., Tsai, C., & Wu, P. (2019). Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening. Mathematics, 7(12), Article 1170. https://doi.org/10.3390/math7121170

One of the leading forms of cancer is colorectal cancer (CRC), which is responsible for increasing mortality in young people. The aim of this paper is to provide an experimental modification of deep learning of Xception with Swish and assess the poss... Read More about Enhancement of Deep Learning in Image Classification Performance Using Xception with the Swish Activation Function for Colorectal Polyp Preliminary Screening.

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening (2019)
Journal Article
Reynisson. (2019). Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening. Molecules, https://doi.org/10.3390/molecules24234346

Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients' immune systems, leading to poor disease outcomes.... Read More about Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening.

Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial (2019)
Journal Article
Fernando, I. N., Bowden, S. J., Herring, K., Brookes, C. L., Ahmed, I., Marshall, A., Grieve, R., Churn f, M., Spooner, D., Latief, T. N., Agrawal, R. K., Brunt, A. M., Stevens, A., Goodman, A., Canney, P., Bishop, J., Ritchie, D., Dunn, J., Poole, C. J., & Rea, D. W. (2020). Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial. Radiotherapy and Oncology, 142, 52-61. https://doi.org/10.1016/j.radonc.2019.10.014

BACKGROUND: The optimal sequence of adjuvant chemotherapy and radiotherapy for breast cancer is unknown. SECRAB assesses whether local control can be improved without increased toxicity. METHODS: SECRAB was a prospective, open-label, multi-centre, ph... Read More about Synchronous versus sequential chemo-radiotherapy in patients with early stage breast cancer (SECRAB): A randomised, phase III, trial.

Barriers and motivators for uptake of cervical cancer prevention strategies in Eastern Europe: Perspective from Latvia (2019)
Journal Article
Pčolkina, K., Sherman, S., MOSS, E., Redman, C., Zodzika, J., Rezeberga, D., Patel, H., Strazdiņa, K., & Viberga, I. (2019). Barriers and motivators for uptake of cervical cancer prevention strategies in Eastern Europe: Perspective from Latvia. https://doi.org/10.15570/actaapa.2019.27

Introduction
The incidence of cervical cancer in Eastern European countries is high, however uptake of available prevention strategies is suboptimal. We explored the knowledge, behaviours and attitudes towards cervical cancer prevention strategie... Read More about Barriers and motivators for uptake of cervical cancer prevention strategies in Eastern Europe: Perspective from Latvia.

Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology? (2019)
Journal Article
Rutter, A., Crees, J., Wright, H., Raseta, M., van Pittius, D., Roach, P., & Sulé-Suso, J. (2019). Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology?. Applied Spectroscopy, 74(2), 178-186. https://doi.org/10.1177/0003702819875828

The rising incidence of cancer worldwide is causing an increase in the workload in pathology departments. This, coupled with advanced analysis methodologies, supports a developing need for techniques that could identify the presence of cancer cells i... Read More about Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology?.

Synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer agents (2019)
Journal Article
Rosa Johnson-Ajinwo, O., Richardson, A., & Li, W. (2019). Synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer agents. Proceedings, 42. https://doi.org/10.3390/proceedings2019022042

Conference abstract, presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.

long term follow-up of FoRT: a phase 3 multi-center prospective randomized trial of radiation therapy for follicular and marginal zone lymphoma (2019)
Presentation / Conference Contribution
Hoskin, P., Kirkwood, A., Popova, B., Schofield, O., Brammer, C., Robinson, M., Brunt, M., Krishnaswamy, M., Illidge, T., Gallop-Evans, E., Syndikus, I., & Clifton-Hadley, L. long term follow-up of FoRT: a phase 3 multi-center prospective randomized trial of radiation therapy for follicular and marginal zone lymphoma

Supplement article.

A survey of knowledge, attitudes and awareness of the human papillomavirus among healthcare professionals across the UK (2019)
Journal Article
Sherman, S., Cohen, C., Denison, H., Bromhead, C., & Patel, H. (2019). A survey of knowledge, attitudes and awareness of the human papillomavirus among healthcare professionals across the UK. European Journal of Public Health, 30(1), 10-16. https://doi.org/10.1093/eurpub/ckz113

Background
Human papillomavirus (HPV) is a common sexually transmitted infection implicated in 5% of cancers worldwide including most cervical cancer cases. In the UK, the HPV vaccine has been offered routinely to girls aged 11-13 since 2008 while c... Read More about A survey of knowledge, attitudes and awareness of the human papillomavirus among healthcare professionals across the UK.

Percutaneous Coronary Intervention in Cancer Patients: A Report of the Prevalence and Outcomes in the United States (2019)
Journal Article
Potts, J., Lopez Mattei, J., Martinez, S., Fischman, D., Mamas, M., Iliescu, C., Holmvang, L., Kwok, C., Ludman, P., De Belder, M., & Rashid, M. (2019). Percutaneous Coronary Intervention in Cancer Patients: A Report of the Prevalence and Outcomes in the United States. European Heart Journal, 1790-+. https://doi.org/10.1093/eurheartj/ehy769

This study aims to examine the temporal trends and outcomes in patients who undergo percutaneous coronary intervention (PCI) with a previous or current diagnosis of cancer, according to cancer type and the presence of metastases.

Methods and resul... Read More about Percutaneous Coronary Intervention in Cancer Patients: A Report of the Prevalence and Outcomes in the United States.

Can patients with multiple breast cancers in the same breast avoid mastectomy by having multiple lumpectomies to achieve equivalent rates of local breast cancer recurrence? A randomised controlled feasibility trial called MIAMI UK (2019)
Journal Article
Brunt. (2019). Can patients with multiple breast cancers in the same breast avoid mastectomy by having multiple lumpectomies to achieve equivalent rates of local breast cancer recurrence? A randomised controlled feasibility trial called MIAMI UK. Annals of Surgical Oncology, 58 - 60

Meeting abstract, from the 20th Annual Meeting of the American-Society-of-Breast-Surgeons Conference, Dallas, Texas, 30 Apr - 5 May, 2019.

Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset (2019)
Journal Article
Agnoletto, C., Corrà, F., Minotti, L., Baldassari, F., Crudele, F., Cook, W. J. J., Di Leva, G., Pio d’Adamo, A., Gasparini, P., & Volinia, S. (2019). Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset. Cancers, 11(4), Article 483. https://doi.org/10.3390/cancers11040483

The release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process. The analysis of CTCs in patients has recently received widespread attention because of its clinical implications, particularly for precision m... Read More about Heterogeneity in Circulating Tumor Cells: The Relevance of the Stem-Cell Subset.

Investigation into the role of small nucleolar RNA U44 in leukaemia (2019)
Thesis
Gawlik, C. Investigation into the role of small nucleolar RNA U44 in leukaemia. (Thesis). Keele University. https://keele-repository.worktribe.com/output/417894

Small nucleolar RNAs (snoRNAs) are a class of small non-coding RNAs that act as guide RNAs for post-transcriptional chemical modifications of ribosomal and spliceosome RNAs. Recent independent reports have indicated that these small non-coding RNAs a... Read More about Investigation into the role of small nucleolar RNA U44 in leukaemia.

RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate (2019)
Journal Article
Bountal, A., Tonge, D. P., & Mourtada-Maarabouni, M. (2019). RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate. International Journal of Biological Macromolecules, 878-891. https://doi.org/10.1016/j.ijbiomac.2019.03.005

Myocardial Infarction Associated Transcript (MIAT) is a subnuclear lncRNA that interferes with alternative splicing and is associated with increased risk of various heart conditions and nervous system tumours. The current study aims to elucidate the... Read More about RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate.

Striking lung cancer response to self-administration of cannabidiol: a case report and literature review (2019)
Journal Article
Sule-Suso, J., Watson, N., van Pittius, D., & Jegannathen, A. (2019). Striking lung cancer response to self-administration of cannabidiol: a case report and literature review. SAGE Open Medical Case Reports, https://doi.org/10.1177/2050313X19832160

In spite of new drugs, lung cancer is associated with a very poor prognosis. Whilst targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow up. Thus, new drugs or re-e... Read More about Striking lung cancer response to self-administration of cannabidiol: a case report and literature review.

Breast reconstruction affects coping mechanisms in breast cancer survivors. (2019)
Journal Article
Lake, B., Fuller, H., Rastall, S., & Usman, T. (2019). Breast reconstruction affects coping mechanisms in breast cancer survivors. Indian Journal of Surgery, 43-50. https://doi.org/10.1007/s12262-017-1712-1

Coping strategies used by women with breast cancer are vital for adjustment to their disease. Whilst it is clear that factors such as age at diagnosis, social support and ethnicity can influence coping mechanisms, there is currently no information ab... Read More about Breast reconstruction affects coping mechanisms in breast cancer survivors..