A note on estimating the Cox-Snell R2 from a reported C statistic (AUROC) to inform sample size calculations for developing a prediction model with a binary outcome. (2020)
Journal Article
(2020). A note on estimating the Cox-Snell R2 from a reported C statistic (AUROC) to inform sample size calculations for developing a prediction model with a binary outcome. Statistics in Medicine, https://doi.org/10.1002/sim.8806

In 2019 we published a pair of articles in Statistics in Medicine that describe how to calculate the minimum sample size for developing a multivariable prediction model with a continuous outcome, or with a binary or time-to-event outcome. As for any... Read More about A note on estimating the Cox-Snell R2 from a reported C statistic (AUROC) to inform sample size calculations for developing a prediction model with a binary outcome..

Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology. (2020)
Journal Article
(2020). Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology. Journal of Medical Imaging and Radiation Sciences, 22-28. https://doi.org/10.1016/j.jmir.2020.11.008

INTRODUCTION: Diagnostic radiographers working in oncology will have frequent contact with the same patients over a prolonged period. This can be mentally exhausting for the radiographer. Compassion fatigue (CF) occurs after repeated exposure to stre... Read More about Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology..

Transoral Robotic Surgery for Residual and Recurrent Oropharyngeal Cancers (2020)
Journal Article
(2020). Transoral Robotic Surgery for Residual and Recurrent Oropharyngeal Cancers. Otolaryngologic Clinics of North America, 1091 -1108. https://doi.org/10.1016/j.otc.2020.07.016

Trans-oral robotic surgery (TORS) was approved by the FDA in 2009 and over the past decade head and neck surgeons have adopted the technology for the benefit of their patients. Whilst the surgical methods have evolved, there has been little considera... Read More about Transoral Robotic Surgery for Residual and Recurrent Oropharyngeal Cancers.

An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure (2020)
Journal Article
(2020). An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure. Radiology Research and Practice, 3246531 - ?. https://doi.org/10.1155/2020/3246531

Introduction: The incidence of pressure ulcers (PUs) presents a substantial threat to patients, especially geriatric patients, those with restricted mobility, and patients suffering from chronic diseases such as cancer. PUs creates a huge financial b... Read More about An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure.

Psychosocial determinants of adherence with oral anticancer treatment: 'we don't need no education' (2020)
Journal Article
(2020). Psychosocial determinants of adherence with oral anticancer treatment: 'we don't need no education'. Acta oncologica, 1 - 9. https://doi.org/10.1080/0284186x.2020.1843190

INTRODUCTION: Given the potentially fatal consequences of inadequate adherence with oral anticancer treatment in persons with cancer, understanding the determinants of adherence is vital. This paper aims at identifying psychosocial determinants of ad... Read More about Psychosocial determinants of adherence with oral anticancer treatment: 'we don't need no education'.

Development of an automated radiotherapy dose accumulation workflow for locally advanced high-risk prostate cancer - A technical report. (2020)
Journal Article
Knight, K., Panettieri, V., Dimmock, M., Ong, A., Tuan, J., Tan, H., …Wright, C. (2020). Development of an automated radiotherapy dose accumulation workflow for locally advanced high-risk prostate cancer - A technical report. Journal of Medical Radiation Sciences, 203 - 210. https://doi.org/10.1002/jmrs.442

An automated dose accumulation and contour propagation workflow using daily cone beam computed tomography (CBCTs) images for prostate cases that require pelvic lymph nodes irradiation (PLNs) was developed. This workflow was constructed using MIM® sof... Read More about Development of an automated radiotherapy dose accumulation workflow for locally advanced high-risk prostate cancer - A technical report..

Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer (2020)
Journal Article
kwong, J. (2020). Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer. BMC Cancer, https://doi.org/10.1186/s12885-020-07455-3

Abstract

Background
Previous studies have shown a major green tea polyphenol (-)-epigallocatechin-3-gallate ((-)-EGCG) as a powerful anti-cancer agent. However, its poor bioavailability and requirement of a high dosage to manifest activity have... Read More about Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer.

Breast Cancer Management Guidelines During COVID-19 Pandemic (2020)
Journal Article
Gowda S, M., Katherine Kabeer, K., Jafferbhoy, S., Marla, S., Soumian, S., Misra, V., …Brunt, A. M. (2020). Breast Cancer Management Guidelines During COVID-19 Pandemic. Indian Journal of Surgery, 82, 251-258. https://doi.org/10.1007/s12262-020-02466-7

The coronavirus disease (COVID-19) pandemic in 2020 has brought about complex challenges in healthcare delivery. With the new rules of lockdown and social distancing and with resources diverted to the management of COVID-19, there are difficulties in... Read More about Breast Cancer Management Guidelines During COVID-19 Pandemic.

Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition (2020)
Journal Article
Paliouras, A. R., Buzzetti, M., Shi, L., Donaldson, I. J., Magee, P., Sahoo, S., …Garofalo, M. (2020). Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition. EMBO Molecular Medicine, 12(7), Article e11099. https://doi.org/10.15252/emmm.201911099

A subset of lung adenocarcinomas is driven by the EML4-ALK translocation. Even though ALK inhibitors in the clinic lead to excellent initial responses, acquired resistance to these inhibitors due to on-target mutations or parallel pathway alterations... Read More about Vulnerability of drug-resistant EML4-ALK rearranged lung cancer to transcriptional inhibition.

Comparison of propagation-based phase-contrast CT and absorption-based CT for breast imaging using synchrotron radiation (2020)
Journal Article
Taba, S., Lewis, S., Baran, P., Arhatari, B., Nesterets, Y., Mayo, S., …Brennan, P. (2020). Comparison of propagation-based phase-contrast CT and absorption-based CT for breast imaging using synchrotron radiation. Proceedings of SPIE, https://doi.org/10.1117/12.2564053

Propagation-based phase-contrast CT (PB-CT) is a novel imaging technique that visualises variations in both X-ray attenuation and refraction. This study aimed to compare the clinical image quality of breast PB-CT using synchrotron radiation with conv... Read More about Comparison of propagation-based phase-contrast CT and absorption-based CT for breast imaging using synchrotron radiation.

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. (2020)
Journal Article
Guinan, M., Benckendorff, C., Smith, M., & Miller, G. (2020). Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules, 25(9), https://doi.org/10.3390/molecules25092050

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, thes... Read More about Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues..

Adherence to Pre-operative Exercise and the Response to Prehabilitation in Oesophageal Cancer Patients (2020)
Journal Article
Halliday, L. J., Doganay, E., Wynter-Blyth, V., Osborn, H., Buckley, J., & Moorthy, K. (2021). Adherence to Pre-operative Exercise and the Response to Prehabilitation in Oesophageal Cancer Patients. Journal of Gastrointestinal Surgery, 25(4), 890-899. https://doi.org/10.1007/s11605-020-04561-2

BACKGROUND: Prehabilitation is thought to reduce post-operative respiratory complications by optimising fitness before surgery. This prospective, single-centre study aimed to establish the effect of pre-operative exercise on cardiorespiratory fitness... Read More about Adherence to Pre-operative Exercise and the Response to Prehabilitation in Oesophageal Cancer Patients.

The impact of migration on the awareness of and attitudes towards cervical cancer prevention in eastern european women in England (2020)
Journal Article
Patel, H., Moss, E., Tincello, D., & Sherman, S. (2020). The impact of migration on the awareness of and attitudes towards cervical cancer prevention in eastern european women in England. Journal of Medical Screening, 40-47

Objectives
It has been hypothesised that the rise in incidence of cervical cancer in England and the fall in screening coverage might be attributable to the effect of migration of Eastern European (EE) born women. The attitudes and behaviours of mig... Read More about The impact of migration on the awareness of and attitudes towards cervical cancer prevention in eastern european women in England.