Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality (2021)
Journal Article
Mamas. (2021). Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality. MedRxiv, https://doi.org/10.1101/2021.11.11.21266212

<h4>Objectives</h4> To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect NHS England waiting list duration and associated mortality. <h4>Design</h4> We constructed a mathematical model... Read More about Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality.

Predictors of postoperative hospital length of stay after total knee arthroplasty. (2021)
Journal Article
(2021). Predictors of postoperative hospital length of stay after total knee arthroplasty. https://doi.org/10.11622/smedj.2021142

INTRODUCTION: To collect and analyse clinical and functional variables of patients undergoing rehabilitation after total knee arthroplasty (TKA), in order to identify which amongst them could influence the post-operative length of hospital stay (LOS)... Read More about Predictors of postoperative hospital length of stay after total knee arthroplasty..

Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England (2021)
Journal Article
Ferguson, R., Prieto-Alhambra, D., Peat, G., Delmestri, A., P Jordan, K., Y Strauss, V., …Silman, A. (2021). Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England. BMJ Open, e046712 - ?. https://doi.org/10.1136/bmjopen-2020-046712

Total hip arthroplasty (THA) surgery for elderly people with multimorbidity increases the risk of serious health hazards including mortality. Whether such background morbidity reduces the clinical benefit is less clear. OBJECTIVE: To evaluate how pre... Read More about Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England.

Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study (2021)
Journal Article
McClelland, D., Blackwell, J. R., O’Beirne, S., Grocott, N. E., & Ogrodnik, P. (2022). Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study. Journal of Shoulder and Elbow Surgery, 31(2), 413-419. https://doi.org/10.1016/j.jse.2021.08.018

Hypothesis: To determine the angle of osteotomy that produces a circular humeral cut surface.
Methods: 49 cadaveric shoulders, from 25 cadavers, underwent sequential humeral head osteotomy from 180 degrees (vertical, in line with the humeral diaphys... Read More about Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study.

Proceedings of International Conference on Biomedical Engineering (2021)
Presentation / Conference
Yang, & Naire. (2021, September). Proceedings of International Conference on Biomedical Engineering. Presented at International Conference on Biomedical Engineering (ICoBE 2021), UniMAP, Malaysia (Virtual)

Aspiration thrombectomy is a life-saving interventional procedure to remove a blood clot from the brain of stroke patients. The pressure and blood flow dynamics during this procedure are crucial in determining the clinical outcomes. A mathematical mo... Read More about Proceedings of International Conference on Biomedical Engineering.

Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia (2021)
Journal Article
Mamas. (2021). Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia. Metabolomics, https://doi.org/10.1007/s11306-021-01827-x

Introduction Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbati... Read More about Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia.

Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review. (2021)
Journal Article
(2021). Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review. Journal of Orthopaedics and Traumatology, https://doi.org/10.1186/s10195-021-00588-6

BACKGROUND: Matrix-induced autologous chondrocyte implantation (mACI) can be performed in a full arthroscopic or mini-open fashion. A systematic review was conducted to investigate whether arthroscopy provides better surgical outcomes compared with t... Read More about Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review..

Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements. (2021)
Journal Article
Dhawan, R., Spencer Jones, R., & Cool, P. (2021). Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements. Knee, 31, 97 - 109. https://doi.org/10.1016/j.knee.2021.05.008

BACKGROUND: Review of mid-term results (five years) for tumour and revision arthroplasty surgery using the Stanmore METS® distal femoral replacement.

METHODS: Data were collected retrospectively for 90 patients for procedures performed between 20... Read More about Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements..

Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. (2021)
Journal Article
Mamas, & Nolan. (2021). Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England. Circulation: Cardiovascular Interventions, 532-543. https://doi.org/10.1161/CIRCINTERVENTIONS.120.010413

Background:
Aortic stenosis requires timely treatment with either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). This study aimed to investigate the indirect impact of coronavirus disease 2019 (COVID-19) o... Read More about Indirect Impact of the COVID-19 Pandemic on Activity and Outcomes of Transcatheter and Surgical Treatment of Aortic Stenosis in England..

Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients (2021)
Journal Article
Rashid, M., Shoaib, A., Mohamed, M., Curzen, N., Ludman, P., Zaman, A., …Mamas, M. A. (2021). Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients. Catheterization and Cardiovascular Interventions, 99(1), 74-84. https://doi.org/10.1002/ccd.29691

OBJECTIVE: To compare the clinical characteristics and outcomes in patients with stable angina who have undergone chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in native arteries with or without prior coronary artery bypass g... Read More about Clinical outcomes of percutaneous coronary intervention for chronic total occlusion in prior coronary artery bypass grafting patients.

Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy (2021)
Journal Article
Hulme, & Wright Bevans. (2021). Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. American Journal of Sports Medicine, 1512-1523

Background: Biomarkers are needed to predict clinical outcome for microfracture and osteotomy surgeries to ensure patients can be better stratified to receive the most appropriate treatment.
Hypothesis/purpose: To identify novel biomarker candidate... Read More about Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy.

Consensus on pre-operative total knee replacement education and prehabilitation recommendations: a UK-based modified Delphi study (2021)
Journal Article
Anderson, A. M., Comer, C., Smith, T. O., Drew, B. T., Pandit, H., Antcliff, D., …McHugh, G. A. (2021). Consensus on pre-operative total knee replacement education and prehabilitation recommendations: a UK-based modified Delphi study. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-021-04160-5

Over 90,000 total knee replacement (TKR) procedures are performed annually in the United Kingdom (UK). Patients awaiting TKR face long delays whilst enduring severe pain and functional limitations. Almost 20% of patients who undergo TKR are not satis... Read More about Consensus on pre-operative total knee replacement education and prehabilitation recommendations: a UK-based modified Delphi study.

Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure (2021)
Journal Article
Sparrow, R., Sanjoy, S., Choi, Y., Elgendy, I. Y., Jneid, H., Villablanca, P. A., …Bagur, R. (2021). Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure. Heart, 107(24), 1946-1955. https://doi.org/10.1136/heartjnl-2020-318650

OBJECTIVE: This manuscript aims to explore the impact of race/ethnicity and socioeconomic status on in-hospital complication rates after left atrial appendage closure (LAAC). METHODS: The US National Inpatient Sample was used to identify hospitalisat... Read More about Racial, ethnic and socioeconomic disparities in patients undergoing left atrial appendage closure.

Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes. (2021)
Journal Article
Mamas. (2021). Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes. Journal of Interventional Cardiology, https://doi.org/10.1155/2021/6654515

Background: While thinner struts are associated with improved clinical outcomes in bare-metal stents (BMS), reducing strut thickness may affect drug delivery from drug-eluting stents (DES) and there are limited data comparing otherwise similar thin a... Read More about Thin Strut CoCr Biodegradable Polymer Biolimus A9-Eluting Stents versus Thicker Strut Stainless Steel Biodegradable Polymer Biolimus A9-Eluting Stents: Two-Year Clinical Outcomes..

Patella resurfacing during total knee arthroplasty is cost-effective and has lower re-operation rates compared to non-resurfacing. (2021)
Journal Article
(2021). Patella resurfacing during total knee arthroplasty is cost-effective and has lower re-operation rates compared to non-resurfacing. Journal of Orthopaedic Surgery and Research, 185 - ?. https://doi.org/10.1186/s13018-021-02295-8

BACKGROUND: The decision to resurface the patella as part of total knee arthroplasty may be influenced by the surgeon's preference, education, training, tradition and geographic location. Advocates for non-resurfacing or selectively resurfacing may c... Read More about Patella resurfacing during total knee arthroplasty is cost-effective and has lower re-operation rates compared to non-resurfacing..

Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis (2021)
Journal Article
Gelbenegger, G., Schoergenhofer, C., Jilma, B., Gager, G. M., Dizdarevic, A. M., Mamas, M. A., …Siller‐Matula, J. M. (2021). Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis. Clinical Pharmacology and Therapeutics, 110(2), 424-431. https://doi.org/10.1002/cpt.2226

Dual antiplatelet therapy (DAPT) and subsequent P2Y12 inhibitor monotherapy, particularly ticagrelor, is an emerging treatment strategy in patients undergoing percutaneous coronary intervention (PCI). This meta-analysis was designed to investigate wh... Read More about Efficacy and Safety of Ticagrelor Monotherapy in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis.

Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy (2021)
Journal Article
Hulme, & Wright, K. (2021). Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. Journal of Bone and Joint Surgery, British Volume, https://doi.org/10.1302/1358-992X.2021.2.008

Objectives
The ability to predict which patients will improve following routine surgeries aimed at preventing the progression of osteoarthritis is needed to aid patients being stratified to receive the most appropriate treatment. This study aimed to... Read More about Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy.

Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution (2021)
Journal Article
Kirkby, M., Sabri, A. B., Scurr, D. J., & Moss, G. P. (2021). Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution. European Journal of Pharmaceutics and Biopharmaceutics, 159, 77-87. https://doi.org/10.1016/j.ejpb.2020.12.014

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide used in the UK as the first-line skin antiseptic prior to surgery in the UK due to its favourable efficacy and safety profile, high affinity for skin binding and minimal reports of resistance... Read More about Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution.

Use and evaluation of assistive technologies for upper limb function in tetraplegia (2021)
Journal Article
Readioff, R., Kamran Siddiqui, Z., Stewart, C., Fulbrook, L., O’Connor, R. J., & Chadwick, E. K. (2021). Use and evaluation of assistive technologies for upper limb function in tetraplegia. Journal of Spinal Cord Medicine, 45(6), 1 - 12. https://doi.org/10.1080/10790268.2021.1878342

Context More than half of all spinal cord injuries (SCI) occur at the cervical level leading to loss of upper limb function, restricted activity and reduced independence. Several technologies have been developed to assist with upper limb functions in... Read More about Use and evaluation of assistive technologies for upper limb function in tetraplegia.

Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting (2021)
Journal Article
Mamas. (2021). Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.14067

Background: Data on the incidence and outcomes of ischemic stroke in patients undergoing coronary artery bypass grafting (CABG) in the current era is limited. The goal of this study was to examine contemporary trends, predictors, and outcomes of isch... Read More about Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting.