Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture (2022)
Journal Article
Chen, R., Ahmed, M. A., & Forsyth, N. R. (2022). Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture. Biomolecules, 12(4), 541. https://doi.org/10.3390/biom12040541

Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this study is t... Read More about Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture.

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. (2021)
Journal Article
Chen. (2021). Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. Alzheimer's Research and Therapy, 194 - ?. https://doi.org/10.1186/s13195-021-00935-z

BACKGROUND: Alzheimer's disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IH... Read More about Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain..

Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. (2020)
Journal Article
Chen, R., Hassan, H., Rawlinson, C., & Morgan, D. (2020). Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. Journal of Experimental Stroke and Translational Medicine, 13(2), 1-12

Rutin, a flavonoid with a wide range of biological activities, has a long history of use in nutritional supplements owing to its action against oxidative stress, inflammation, and hyperglycemia. Because of its pharmacological properties such as antio... Read More about Pharmacological properties of rutin and its potential uses for Alzheimer’s disease..