Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine (2021)
Journal Article
Harper. (2022). Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine. Cell Calcium, 101, 102522 - 102522. https://doi.org/10.1016/j.ceca.2021.102522

Human platelets regulate agonist-evoked Ca2+ signalling through Ca2+ release from and sequestration into acidic organelles. Previous studies have pharmacologically characterised the presence of a Ca2+-H+ exchanger in these organelles. This exchanger... Read More about Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine.

The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models (2021)
Journal Article
Njoroge, W., Hernández Hernández, A. C., Idris Musa, F., Butler, R., Harper, A. G. S., & Yang, Y. (2021). The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models. Pharmaceutics, 13(3), Article 340. https://doi.org/10.3390/pharmaceutics13030340

Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo... Read More about The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models.

Controlling human platelet activation with calcium-binding nanoparticles (2020)
Journal Article
Cabrera, D., Walker, K., Moise, S., Telling, N. D., & Harper, A. G. (2020). Controlling human platelet activation with calcium-binding nanoparticles. Nano Research, 13, Article 2697–2705. https://doi.org/10.1007/s12274-020-2912-8

We introduce a neural method that is able to fuse concepts from a knowledge base with the context information for the task of grouping of aspect terms. Rather than only using context information, we use the corresponding concepts of aspect terms as a... Read More about Controlling human platelet activation with calcium-binding nanoparticles.

Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation (2020)
Journal Article
Harper. (2020). Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation. Cell Calcium, 90, Article 102248. https://doi.org/10.1016/j.ceca.2020.102248

Human platelets use a rise in cytosolic Ca2+ concentration to activate all stages of thrombus formation, however, how they are able to decode cytosolic Ca2+ signals to trigger each of these independently is unknown. Other cells create local Ca2+ sign... Read More about Human platelets use a cytosolic Ca2+ nanodomain to activate Ca2+-dependent shape change independently of platelet aggregation.