Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary (2022)
Journal Article
Fuller, H., & Storey, E. (2022). Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary. Cells, https://doi.org/10.3390/cells11244065

Mutations in genes encoding proteins associated with the linker of nucleoskel-eton and cytoskeleton (LINC) complex within the nuclear envelope cause dif-ferent diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous... Read More about Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary.

Determining the role of epigenetics in telomerase regulation (2022)
Thesis
Dogan, F. Determining the role of epigenetics in telomerase regulation. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424526

Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization. Telomerase macromolecule is the primary enzyme responsible for telomere elongation. Telom... Read More about Determining the role of epigenetics in telomerase regulation.

Remote control healing for osteoarthritis repair (2022)
Thesis
Echevarria, I. Remote control healing for osteoarthritis repair. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424544

Articular cartilage is a key tissue for the normal functioning of the joints, with a trend for degradation with aging and physical activity. The lack of vascularisation hinders the self-repair, and often a scar tissue replaces the damaged cartilage,... Read More about Remote control healing for osteoarthritis repair.

Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England (2022)
Thesis
Thayer, N. M. Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424548

In England, community pharmacies provide services commissioned either nationally or locally. Local commissioning exhibits variation in specification and implementation, exemplified by Emergency Hormonal Contraception (EHC) services. A literature revi... Read More about Factors influencing the commissioning and provision of community pharmacy Emergency Hormonal Contraception services in England.

Phenotypic characterization of regional human meniscus progenitor cells. (2022)
Journal Article
(2022). Phenotypic characterization of regional human meniscus progenitor cells. Frontiers in Bioengineering and Biotechnology, 1003966 - ?. https://doi.org/10.3389/fbioe.2022.1003966

Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues. In... Read More about Phenotypic characterization of regional human meniscus progenitor cells..

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation (2022)
Journal Article
Mottershead. (2022). Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation. https://doi.org/10.22074/CELLJ.2022.8155

Objective: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation.

Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking. (2022)
Journal Article
Reynisson. (2022). Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2022.128909

Tyrosyl-DNA phosphodiesterase 1(TDP1) is a promising target for a new therapy in oncological disease as an adjunct to topoisomerase 1 (TOP1) drugs. In this paper, novel thiazolidin-4-one derivatives with a benzyl and monoterpene substituents were syn... Read More about Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking..

A clinical pharmacists role in primary general practice (2022)
Journal Article
(2022). A clinical pharmacists role in primary general practice. The Journal of Academic Development and Education, https://doi.org/10.21252/y0q3-sn26

Clinical pharmacist leaders are valued by the NHS because they are well educated, demonstrating excellent analytical and evidence-based thinking skills and professional competency. This reliability often stems from seeing the pharmacy team accepting... Read More about A clinical pharmacists role in primary general practice.

Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics (2022)
Journal Article
Hu, B., Rotherham, M., Farrow, N., Roach, P., Dobson, J., & El Haj, A. J. (2022). Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics. International Journal of Molecular Sciences, 23(17), Article 10164. https://doi.org/10.3390/ijms231710164

Wnt signaling plays an important role in embryogenesis and adult stem cell homeostasis. Its diminished activation is implicated in osteoporosis and degenerative neural diseases. However, systematic administration of Wnt-signaling agonists carries ris... Read More about Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics.

Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors (2022)
Journal Article
Xie, M., Leng, T., Maysami, S., Pearson, A., Simon, R., Xiong, Z.-G., & Meller, R. (2022). Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors. Biomolecules, 12(9), Article 1214. https://doi.org/10.3390/biom12091214

In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning). Electrophysiological studies show NMDA receptor function is reduced following preconditioning... Read More about Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors.

New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model (2022)
Journal Article
Dragomanova, S., Lazarova, M., Munkuev, A., Suslov, E., Volcho, K., Salakhutdinov, N., Bibi, A., Reynisson, J., Tzvetanova, E., Alexandrova, A., Georgieva, A., Uzunova, D., Stefanova, M., Kalfin, R., & Tancheva, L. (2022). New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model. Molecules, 27(17), Article 5456. https://doi.org/10.3390/molecules27175456

Alzheimer’s disease (AD) is a neurodegenerative disease associated with memory impairment and other central nervous system (CNS) symptoms. Two myrtenal–adamantane conjugates (MACs) showed excellent CNS potential against Alzheimer’s models. Adamantane... Read More about New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model.

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study (2022)
Journal Article
Simons, G., Ismail, N., Sandhu, K., Mallen, C. D., Stack, R. J., Pontefract, S., Raza, K., & Falahee, M. (in press). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 6, Article 50. https://doi.org/10.1186/s41927-022-00280-0

<h4>Background: </h4> Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. Howeve... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study.

Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine (2022)
Journal Article
Dale. (2022). Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine. Tissue engineering. Part A, 249 - 250. https://doi.org/10.1089/ten.tea.2022.29030.abstracts

*Purpose/Objectives: Prolonged alveolar air leaks as post-surgical complications to routine lung resections and biopsies are a significant cause for patient morbidity. Extended duration of chest tube drainage and emergency revision surgeries are the... Read More about Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine.

Exploring community pharmacists' use of health literacy interventions in their everyday practice. (2022)
Journal Article
White, S., & Cork, T. (2022). Exploring community pharmacists' use of health literacy interventions in their everyday practice. Research in Social and Administrative Pharmacy, 18(11), 3948-3952. https://doi.org/10.1016/j.sapharm.2022.06.007

BACKGROUND: Limited health literacy often results in people inadequately understanding medicines-related information and subsequently not taking medicines as prescribed. Using health literacy interventions is important for community pharmacists, as t... Read More about Exploring community pharmacists' use of health literacy interventions in their everyday practice..

Educational supervision, assessment and feedback for pharmacists (2022)
Journal Article
O'Byrne, R., & Warren, S. (2022). Educational supervision, assessment and feedback for pharmacists. Pharmaceutical Journal, https://doi.org/10.1211/pj.2022.1.148078

Workplace learning has formed part of preregistration training (now foundation training) for many years, and supervision of this is becoming more embedded into pharmacy education and development — both at foundation and advanced level. Effective supe... Read More about Educational supervision, assessment and feedback for pharmacists.

A multimodal approach to biomarker discovery for spinal cord injury (2022)
Thesis
Bernardo Harrington, G. M. A multimodal approach to biomarker discovery for spinal cord injury. (Thesis). Keele University. https://keele-repository.worktribe.com/output/423508

The extent of the devastating outcomes following spinal cord injury, particularly with respect to neurological function, are difficult to predict. This can make it difficult to plan clinical care and manage patient expectations, both of which can hav... Read More about A multimodal approach to biomarker discovery for spinal cord injury.

Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke (2022)
Thesis
Singh, A. Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke. (Thesis). Keele University. https://keele-repository.worktribe.com/output/423512

Ischaemic stroke is the most common form of stroke, accounting for appropriate 87% of all strokes. Reperfusion is the only immediate treatment option following ischaemic stroke, however, this option is only applicable to a small percentage of patient... Read More about Activation of Hypoxia Inducible Factor pathway for neuroprotection in in vitro models of ischaemic stroke.

Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka. (2022)
Journal Article
Gunasekara, S., Nuwangi, H., Wickramasinghe, N., Weerakoon, K., Price, H. P., Dikomitis, L., & Agampodi, S. B. (2022). Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka. Pathogens, 11(6), Article 680. https://doi.org/10.3390/pathogens11060680

Having an effective surveillance system is imperative to take timely and appropriate actions for disease control and prevention. In Sri Lanka, leishmaniasis was declared as a notifiable disease in 2008. This paper presents a comprehensive compilation... Read More about Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka..

Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice (2022)
Journal Article
Allinson, M., Black, P., & White, S. (2022). Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice. American journal of pharmaceutical education, 86(5), Article 8643. https://doi.org/10.5688/ajpe8643

Objective. For many UK pharmacy students there are minimal opportunities to learn, or be exposed to, different ways of dealing with ethical and professional dilemmas in real life practice during undergraduate education. This study aimed to explore th... Read More about Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice.

Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells (2022)
Journal Article
Dogan, F., Aljumaily, R. M. K., Kitchen, M., & Forsyth, N. R. (2022). Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells. International Journal of Molecular Sciences, 23(10), Article 5854. https://doi.org/10.3390/ijms23105854

Pluripotent stem cells (PSC) possess unlimited proliferation, self-renewal, and a differentiation capacity spanning all germ layers. Appropriate culture conditions are important for the maintenance of self-renewal, pluripotency, proliferation, differ... Read More about Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells.