Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40 (2015)
Journal Article
Waring, M. J., Baker, D. J., Bennett, S. N., Dossetter, A. G., Fenwick, M., Garcia, R., …Wilkinson, G. (2015). Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40. MedChemComm, 2015(6), 1024-1029. https://doi.org/10.1039/C5MD00037H

A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable... Read More about Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40.

Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice (2014)
Journal Article
Bake, T., Murphy, M., Morgan, D., & Mercer, J. (2014). Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice. Appetite, 77, 60 - 71. https://doi.org/10.1016/j.appet.2014.02.020

Male C57BL/6 mice fed ad libitum on control diet but allowed access to a palatable high fat diet (HFD) for 2?h a day during the mid-dark phase rapidly adapt their feeding behaviour and can consume nearly 80% of their daily caloric intake during this... Read More about Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice.