Computer modelling of optical materials for laser applications: rare earth doping in YLiF4 and BaMgF4
Thesis
(2014). Computer modelling of optical materials for laser applications: rare earth doping in YLiF4 and BaMgF4
Polyhedral oligomeric silsesquioxane based precursors as linkers for porous materials
Thesis
Smith, G. (2016). Polyhedral oligomeric silsesquioxane based precursors as linkers for porous materialsWithin this thesis, the organic synthesis and characterisation of various polyhedral oligomeric silsesquioxane (POSS) based compounds has been explored. The target POSS based compounds studied have been chosen because of their eight functionalised or... Read More about Polyhedral oligomeric silsesquioxane based precursors as linkers for porous materials.
Heterocyclic NO-donors as anti-cancer agents
Thesis
(2012). Heterocyclic NO-donors as anti-cancer agentsNitric oxide (NO) is involved in numerous biological processes including cancer, where this small diatomic radical can exert both pro- and anti-cancer effects. Two series of novel NO-donors were synthesised in this work, the first representing an ext... Read More about Heterocyclic NO-donors as anti-cancer agents.
An investigation into the biotransformation and enzymology of a methyl-imidazole containing cyclin dependent kinase inhibitor
Thesis
(2011). An investigation into the biotransformation and enzymology of a methyl-imidazole containing cyclin dependent kinase inhibitorThe cyclin dependent kinase inhibitor AZD5438 was in development by AstraZeneca for treatment of solid tumours where it showed a pattern of emerging toxicity loosely correlated with exposure during clinical trials in patients. Metabolites identified... Read More about An investigation into the biotransformation and enzymology of a methyl-imidazole containing cyclin dependent kinase inhibitor.
Design of novel porous melamine-formaldehyde materials for molecular recognition
Thesis
(2011). Design of novel porous melamine-formaldehyde materials for molecular recognitionPorous materials have played a pivotal role in the hosting of guest species. They provide a good diffusion medium, display high surface area and often the pores are size specific and bear the correct functionality to enhance retention of analytes. Th... Read More about Design of novel porous melamine-formaldehyde materials for molecular recognition.