Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines (2023)
Journal Article
van Beek, C. M., Swarbrook, A. M., Creissen, C. E., Hawes, C. S., Gazis, T. A., & Matthews, P. D. (2023). Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines. Chemistry - A European Journal, 30(8), Article e202301944. https://doi.org/10.1002/chem.202301944

Boron‐ and nitrogen‐doped polycyclic aromatic hydrocarbons (B‐PAHs) have established a strong foothold in the realm of organic electronics. However, their catalytic potential remains largely untapped. In this study, we synthesise and characterise two... Read More about Juggling Optoelectronics and Catalysis: The Dual Talents of Bench Stable 1,4‐Azaborinines.

Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes (2023)
Journal Article
Hegarty, I. N., Hawes, C. S., & Gunnlaugsson, T. (2023). Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes. Organic Chemistry Frontiers, 10(8), 1915-1926. https://doi.org/10.1039/D3QO00232B

The synthesis of chiral a-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands 4-6 designed by combining the coordination properties of two well-known ligand structures within a single unit is described. The self-assembly formation bet... Read More about Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes.

Fused aza-heterocyclic ligands: expanding the MOF chemist's toolbox (2022)
Journal Article
Wood, O. G., & Hawes, C. S. (2022). Fused aza-heterocyclic ligands: expanding the MOF chemist's toolbox. CrystEngComm, 24(47), 8197-8207. https://doi.org/10.1039/d2ce01475k

Azolate-containing ligands have played an important role in the development of water-stable metal-organic frameworks (MOFs) and related materials due to their particularly strong bonding with earth-abundant first row transition metal ions. Fused ring... Read More about Fused aza-heterocyclic ligands: expanding the MOF chemist's toolbox.

Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands (2022)
Journal Article
Slyusarchuk, V. D., O’Brien, B. J., & Hawes, C. S. (in press). Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands. Journal of Coordination Chemistry, 75(15-16), 2039-2061. https://doi.org/10.1080/00958972.2022.2130059

Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands

Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase. (2022)
Journal Article
Ahmadipour, S., Wahart, A., Dolan, J., Beswick, L., Hawes, C., Field, R., & Miller, G. (2022). Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase. Beilstein Journal of Organic Chemistry, 18, 1379 - 1384. https://doi.org/10.3762/bjoc.18.142

Sufferers of cystic fibrosis are at significant risk of contracting chronic bacterial lung infections. The dominant pathogen in these cases is mucoid Pseudomonas aeruginosa. Such infections are characterised by overproduction of the exopolysaccharide... Read More about Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase..

A Reversibly Porous Supramolecular Peptide Framework** (2022)
Journal Article
Brightwell, D. F., Truccolo, G., Samanta, K., Fenn, E. J., Holder, S. J., Shepherd, H. J., …Palma, A. (2022). A Reversibly Porous Supramolecular Peptide Framework**. Chemistry - A European Journal, 28(66), https://doi.org/10.1002/chem.202202368

The ability to use bio‐inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self‐assemble into a reversibly porous, crystallin... Read More about A Reversibly Porous Supramolecular Peptide Framework**.

An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions (2022)
Journal Article
Chernobryva, M., Motevalli, M., Hawes, C. S., & Watkinson, M. (2022). An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions. Journal of Molecular Structure, 1259, 132736 - 132736. https://doi.org/10.1016/j.molstruc.2022.132736

The steric influences of the triazole side chains in two tripodal chelating ligands tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) and tris[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]amine (TPTA) are explored through structural studies of four... Read More about An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions.

Tripodal 1,3,5-benzenetricarboxamide ligand with dipicolinic acid units and its binding with Eu(III) ions (2022)
Journal Article
Klangwart, N., Ruijs, C., Hawes, C. S., Gunnlaugsson, T., & Kotova, O. (2022). Tripodal 1,3,5-benzenetricarboxamide ligand with dipicolinic acid units and its binding with Eu(III) ions. Supramolecular Chemistry, 34(1), 10-19. https://doi.org/10.1080/10610278.2023.2177162

The synthesis and characterisation of tripodal ligand 1 containing 1,3,5-benzenetricarboxamide core and diethyl 4-(phenylethynyl)pyridine-2,6-dicarboxylate is described. The crystal structure of the intermediate tripodal molecule 7 exhibits an unusua... Read More about Tripodal 1,3,5-benzenetricarboxamide ligand with dipicolinic acid units and its binding with Eu(III) ions.

Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues (2021)
Journal Article
Guinan, M., Huang, N., Hawes, C. S., Lima, M. A., Smith, M., & Miller, G. J. (2021). Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues. Organic and Biomolecular Chemistry, 20(7), 1401-1406. https://doi.org/10.1039/d1ob02097h

Analogues of the canonical nucleosides required for nucleic acid synthesis have a longstanding presence and proven capability within antiviral and anticancer research. 4'-Thionucleosides, that incorporate bioisosteric replacement of furanose oxygen w... Read More about Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues.

Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition (2021)
Journal Article
Kumawat, L. K., Wynne, C., Cappello, E., Fisher, P., Brennan, L. E., Strofaldi, A., …Elmes, R. B. P. (2021). Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition. ChemPlusChem, 86(8), 1058-1068. https://doi.org/10.1002/cplu.202100275

The synthesis and characterisation of two novel self‐assembled amphiphiles (SSAs) SQS‐1 and SQS‐2 are reported. Both compounds, based on the squaramide motif, were fully soluble in a range of solvents and were shown to undergo self‐assembly through a... Read More about Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition.

Coordination Sphere Hydrogen Bonding as a Structural Element in Metal-Organic Frameworks (2021)
Journal Article
Hawes, C. S. (2021). Coordination Sphere Hydrogen Bonding as a Structural Element in Metal-Organic Frameworks. Dalton Transactions, 50(18), 6034-6049. https://doi.org/10.1039/d1dt00675d

In the design of new metal–organic frameworks, the constant challenges of framework stability and structural predictability continue to influence ligand choice in favour of well-studied dicarboxylates and similar ligands. However, a small subset of k... Read More about Coordination Sphere Hydrogen Bonding as a Structural Element in Metal-Organic Frameworks.

Supramolecular aggregation properties of 4-(N-morpholino)-1,8-naphthalimide based fluorescent materials (2021)
Journal Article
Hawes, C. S. (2021). Supramolecular aggregation properties of 4-(N-morpholino)-1,8-naphthalimide based fluorescent materials. Materials Chemistry Frontiers, https://doi.org/10.1039/d1qm00091h

Here we report the synthesis of two morpholino-substituted naphthalimide ligands, N-(3-picolyl)-4-(N-morpholino)-1,8-naphthalimide L1 and N-benzyl-4-(N-morpholino)-1,8-naphthalimide L2, and study their supramolecular properties in the crystalline, so... Read More about Supramolecular aggregation properties of 4-(N-morpholino)-1,8-naphthalimide based fluorescent materials.

Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline (2020)
Journal Article
Goodwin, J. W., Kruger, P. E., & Hawes, C. S. (2020). Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline. Journal of Coordination Chemistry, 74(1-3), 341-360. https://doi.org/10.1080/00958972.2020.1868041

In this work we report the coordination chemistry of a rigid heterotopic ligand 1H-pyrazolo[4,3-h]quinoline HL1 in copper(II) and zinc(II) complexes for the first time, and examine both the structural properties and solution-phase behaviour of these... Read More about Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline.

Balancing connectivity with function in silver(i) networks of pyridyltriazole (tzpa) ligands results in the formation of a metallogel (2020)
Journal Article
Hegarty, I. N., Dalton, H. L., Lynes, A. D., Haffner, B., Möbius, M. E., Hawes, C. S., & Gunnlaugsson, T. (2020). Balancing connectivity with function in silver(i) networks of pyridyltriazole (tzpa) ligands results in the formation of a metallogel. Dalton Transactions, 7364-7372. https://doi.org/10.1039/D0DT01421D

A new flexible and divergent 1,2,3-triazol-4-yl-picolinamide (tzpa) ligand 2 and the half-equivalent model ligand 1, both functionalised with pendant 3-pyridyl groups, are reported and their coordination behaviour with silver(i) ions is explored, bot... Read More about Balancing connectivity with function in silver(i) networks of pyridyltriazole (tzpa) ligands results in the formation of a metallogel.

A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme. (2020)
Journal Article
Yuan, D., Cai, N., Xu, J., Miao, D., Zhang, S., Woodfine, S. E., …Watkinson, M. (2020). A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme. ChemPlusChem, 85(6), 1210 - 1219. https://doi.org/10.1002/cplu.202000337

The development of a team-based approach to research-led transnational practical chemistry teaching is described in which a team of five Chinese students on an articulated transnational degree programme, supported by a team of academic and technical... Read More about A Series of Manganese(III) Salen Complexes as a Result of Team-Based Inquiry in a Transnational Education Programme..

Cyclic Aliphatic Hydrocarbons as Linkers in Metal-Organic Frameworks: New Frontiers for Ligand Design. (2020)
Journal Article
Hawes, C. S. (2020). Cyclic Aliphatic Hydrocarbons as Linkers in Metal-Organic Frameworks: New Frontiers for Ligand Design. ChemPlusChem, 845 - 854. https://doi.org/10.1002/cplu.202000206

In this Minireview we outline the development of cyclic aliphatic moieties as ligands in metal-organic frameworks (MOFs), with a focus on the relationship between ligand design and synthesis and the properties of the subsequent materials. Aliphatic l... Read More about Cyclic Aliphatic Hydrocarbons as Linkers in Metal-Organic Frameworks: New Frontiers for Ligand Design..

Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+ (2019)
Journal Article
Fang, L., Trigiante, G., Crespo-Otero, R., Hawes, C. S., Philpott, M. P., Jones, C. R., & Watkinson, M. (2019). Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. Chemical Science, 10(47), 10881-10887. https://doi.org/10.1039/C9SC04300D

Zn2+ plays an important role in the normal function of the endoplasmic reticulum (ER) and its deficiency can cause ER stress, which is related to a wide range of diseases. In order to provide tools to better understand the role of mobile Zn2+ in ER p... Read More about Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+.

Synthesis, coordination chemistry and photophysical properties of naphtho-fused pyrazole ligands (2019)
Journal Article
Hawes, C. S. (2019). Synthesis, coordination chemistry and photophysical properties of naphtho-fused pyrazole ligands. CrystEngComm, 5152-5163. https://doi.org/10.1039/c9ce01074b

The synthesis of two p-extended pyrazole ligands is reported, with naphtho[2,1-d]-1H-pyrazole HL1 prepared in a modified Jacobson indazole synthesis from 1-amino-2-methylnaphthalene, and subsequent arylation with 2-bromopyridine giving the chelating... Read More about Synthesis, coordination chemistry and photophysical properties of naphtho-fused pyrazole ligands.

Unexpected linkage isomerism in chiral tetranuclear bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) grids (2019)
Journal Article
Hegarty, I. N., Dalton, H. L., Henwood, A. F., Hawes, C. S., & Gunnlaugsson, T. (2019). Unexpected linkage isomerism in chiral tetranuclear bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) grids. Chemical Communications, 9523-9526. https://doi.org/10.1039/c9cc03316e

The synthesis of a chiral bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligand is described and its coordination chemistry with Cu(NO3)2 and [Cu(MeCN)4]PF6 is explored in the crystalline phase as well as in solution. Chiral [2 × 2] tetranuc... Read More about Unexpected linkage isomerism in chiral tetranuclear bis-tridentate (1,2,3-triazol-4-yl)-picolinamide (tzpa) grids.

Substituent effects in the zinc(II) coordination chemistry of isomeric pyridylpyrazole ligands (2019)
Journal Article
Chen, P., Ge, W., Lu, Y., Wu, Z., Xu, J., Woodfine, S. E., …Hawes, C. S. (2019). Substituent effects in the zinc(II) coordination chemistry of isomeric pyridylpyrazole ligands. Journal of Coordination Chemistry, https://doi.org/10.1080/00958972.2019.1587613

Pyrazoles with unsymmetric substitution are useful ligands in coordination chemistry, but are under-developed due to synthetic challenges in accessing the pure isomers. We have prepared four new structurally related N-(2-pyridyl)-3,5-dialkylpyrazole... Read More about Substituent effects in the zinc(II) coordination chemistry of isomeric pyridylpyrazole ligands.