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Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions (2021)
Journal Article
Hafezi, M., Nouri Khorasani, S., Zare, M., Esmaeely Neisiany, R., & Davoodi, P. (2021). Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions. Polymers, 13(23), Article 4199. https://doi.org/10.3390/polym13234199

Cartilage is a tension- and load-bearing tissue and has a limited capacity for intrinsic self-healing. While microfracture and arthroplasty are the conventional methods for cartilage repair, these methods are unable to completely heal the damaged tis... Read More about Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions.

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. (2021)
Journal Article
Chen. (2021). Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. Alzheimer's Research and Therapy, 194 - ?. https://doi.org/10.1186/s13195-021-00935-z

BACKGROUND: Alzheimer's disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IH... Read More about Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain..

Facile synthesis and biological evaluation of chrysin derivatives (2021)
Journal Article
Omonga, N., Zia, Z., Ghanbour, H., Ragazzon-Smith, A., Foster, H., Hadfield, J., & Ragazzon, P. (2021). Facile synthesis and biological evaluation of chrysin derivatives. Journal of Chemical Research, 1083-1092. https://doi.org/10.1177/17475198211057467

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,... Read More about Facile synthesis and biological evaluation of chrysin derivatives.

Building Capacity Through ICCPR Cardiovascular Rehabilitation Foundations Certification (CRFC) (2021)
Journal Article
Grace, S., Atrey, A., Ghisi, G., Buckley, J., Mola, A., Heald, F., Contractor, A., Lopez-Jimenez, F., & Babu, A. (2021). Building Capacity Through ICCPR Cardiovascular Rehabilitation Foundations Certification (CRFC). Journal of Cardiopulmonary Rehabilitation and Prevention, https://doi.org/10.1097/hcr.0000000000000655

Purpose: The International Council of Cardiovascular Prevention and Rehabilitation (ICCPR) developed an online Cardiovascular Rehabilitation Foundations Certification (CRFC; https://globalcardiacrehab.com/Certification) in October 2017, to build card... Read More about Building Capacity Through ICCPR Cardiovascular Rehabilitation Foundations Certification (CRFC).

The changing landscape of cardiac rehabilitation; from early mobilisation and reduced mortality to chronic multi-morbidity management (2021)
Journal Article
Buckley, J. (2021). The changing landscape of cardiac rehabilitation; from early mobilisation and reduced mortality to chronic multi-morbidity management. Disability and Rehabilitation, 3515 - 3522. https://doi.org/10.1080/09638288.2021.1921062

Aim
This paper aims to demonstrate how the rationale and delivery of cardiac rehabilitation (CR), in those countries with long term established standards of practice, has changed over the past eight decades.

Methods
A narrative report based on t... Read More about The changing landscape of cardiac rehabilitation; from early mobilisation and reduced mortality to chronic multi-morbidity management.

GRADE concept paper 2: Concepts for Judging Certainty on the Calibration of Prognostic Models in a Body of Validation Studies. (2021)
Journal Article
(2021). GRADE concept paper 2: Concepts for Judging Certainty on the Calibration of Prognostic Models in a Body of Validation Studies. Journal of Clinical Epidemiology, 202-211. https://doi.org/10.1016/j.jclinepi.2021.11.024

Prognostic models combine several prognostic factors to provide an estimate of the likelihood (or risk) of future events in individual patients, conditional on their prognostic factor values. A fundamental part of evaluating prognostic models is unde... Read More about GRADE concept paper 2: Concepts for Judging Certainty on the Calibration of Prognostic Models in a Body of Validation Studies..

Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study). (2021)
Journal Article
Mamas. (2021). Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study). American Journal of Cardiology, 8 - 18. https://doi.org/10.1016/j.amjcard.2021.07.054

Little is known about how frequently do-not-resuscitate (DNR) orders are placed in patients with acute myocardial infarction (AMI), the types of patients in which they are placed, treatment strategies or clinical outcomes of such patients. Using the... Read More about Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study)..

Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates (2021)
Journal Article
Reynisson, J., Wieczorek-Błauż, A., Kowalczyk, K., Błauż, A., Makal, A., Pawlędzio, S., Eurtivong, C., Arabshahi, H. J., Hartinger, C. G., Rychlik, B., & Plażuk, D. (2021). Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates. Dalton Transactions, 51(2), 491-508. https://doi.org/10.1039/d1dt03553c

The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol - the first low molecular weight kinesin spin... Read More about Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates.

How children in Sweden accessed and perceived information during the first phase of the Covid-19 pandemic (2021)
Journal Article
Protheroe. (2021). How children in Sweden accessed and perceived information during the first phase of the Covid-19 pandemic. Scandinavian Journal of Public Health, 144-151. https://doi.org/10.1177/14034948211051884

Aim: To describe how children in Sweden accessed and perceived information about SARS-CoV2 and Covid-19 during the first phase of the outbreak. Methods: This study is a substudy of an international cross-sectional online mixed methods survey examinin... Read More about How children in Sweden accessed and perceived information during the first phase of the Covid-19 pandemic.

Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles (2021)
Journal Article
Curtis. (2021). Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles. Nanomaterials, 2976 - 2976. https://doi.org/10.3390/nano11112976

Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or 'know-how'. Additionally, standard protocols do no... Read More about Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles.

Association of SARS-CoV-2 Infection With Psychological Distress, Psychotropic Prescribing, Fatigue, and Sleep Problems Among UK Primary Care Patients. (2021)
Journal Article
Chew-Graham. (2021). Association of SARS-CoV-2 Infection With Psychological Distress, Psychotropic Prescribing, Fatigue, and Sleep Problems Among UK Primary Care Patients. Jama Network Open, e2134803 - ?. https://doi.org/10.1001/jamanetworkopen.2021.34803

Importance: Infection with SARS-CoV-2 is associated with fatigue and sleep problems long after the acute phase of COVID-19. In addition, there are concerns of SARS-CoV-2 infection causing psychiatric illness; however, evidence of a direct effect is i... Read More about Association of SARS-CoV-2 Infection With Psychological Distress, Psychotropic Prescribing, Fatigue, and Sleep Problems Among UK Primary Care Patients..

Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT (2021)
Journal Article
Adab, P., Jordan, R. E., Fitzmaurice, D., Ayres, J. G., Cheng, K., Cooper, B. G., Daley, A., Dickens, A., Enocson, A., Greenfield, S., Haroon, S., Jolly, K., Jowett, S., Lambe, T., Martin, J., Miller, M. R., Rai, K., Riley, R. D., Sadhra, S., Sitch, A., …Turner, A. (2021). Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT. Programme Grants for Applied Research, 9(13), 1 - 148. https://doi.org/10.3310/pgfar09130

BackgroundChronic obstructive pulmonary disease is a major contributor to morbidity, mortality and health service costs but is vastly underdiagnosed. Evidence on screening and how best to approach this is not clear. There are also uncertainties aroun... Read More about Case-finding and improving patient outcomes for chronic obstructive pulmonary disease in primary care: the BLISS research programme including cluster RCT.

Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance (2021)
Journal Article
Pearson. (2021). Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules, 6581 - 6581. https://doi.org/10.3390/molecules26216581

Glyceryl trinitrate (GTN) is one of the earliest known treatments for angina with a fascinating history that bridges three centuries. However, despite its central role in the nitric oxide (NO) story as a NO-donating compound, establishing the precise... Read More about Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance.

Physoxia alters human mesenchymal stem cell secretome (2021)
Journal Article
(2021). Physoxia alters human mesenchymal stem cell secretome. Journal of Tissue Engineering, https://doi.org/10.1177/20417314211056132

The human mesenchymal stem cell (hMSC) secretome has pleiotropic effects which underpin their therapeutic potential. hMSC serum-free conditioned media (SFCM) has been determined to contain a variety of cytokines with roles in regeneration and suppres... Read More about Physoxia alters human mesenchymal stem cell secretome.

Predictors of postoperative hospital length of stay after total knee arthroplasty. (2021)
Journal Article
(2021). Predictors of postoperative hospital length of stay after total knee arthroplasty. https://doi.org/10.11622/smedj.2021142

INTRODUCTION: To collect and analyse clinical and functional variables of patients undergoing rehabilitation after total knee arthroplasty (TKA), in order to identify which amongst them could influence the post-operative length of hospital stay (LOS)... Read More about Predictors of postoperative hospital length of stay after total knee arthroplasty..

What non-pharmacological treatments do people with polymyalgia rheumatica try: results from the PMR Cohort Study (2021)
Journal Article
Weddell, J., Hider, S., Mallen, C., & Muller, S. (2022). What non-pharmacological treatments do people with polymyalgia rheumatica try: results from the PMR Cohort Study. Rheumatology International, 285-290. https://doi.org/10.1007/s00296-021-05036-6

Polymyalgia rheumatica (PMR) is common. The mainstay of treatment, glucocorticoids, are associated with significant adverse effects and many patients remain on high doses for a number of years. Little is known about the use of other, non-pharmacologi... Read More about What non-pharmacological treatments do people with polymyalgia rheumatica try: results from the PMR Cohort Study.

AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. (2021)
Journal Article
Morelle, J., Marechal, C., Yu, Z., Debaix, H., Corre, T., Lambie, M., Verduijn, M., Dekker, F., Bovy, P., Evenepoel, P., Bammens, B., Selgas, R., Bajo, M. A., Coester, A. M., Sow, A., Hautem, N., Struijk, D. G., Krediet, R. T., Balligand, J.-L., Goffin, E., …Devuyst, O. (2021). AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. New England Journal of Medicine, 385, 1570 - 1580. https://doi.org/10.1056/NEJMoa2034279

BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribut... Read More about AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis..

Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. (2021)
Journal Article
(2021). Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. Cells, https://doi.org/10.3390/cells10112819

BACKGROUND: Liver transplantation remains the only viable therapy for liver failure but has a severely restricted utility. Here, we aimed to decellularize rat livers to form acellular 3D bio-scaffolds suitable for seeding with induced pluripotent cel... Read More about Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation..

COVID-19 vaccination acceptability in the UK at the start of the vaccination programme: a nationally representative cross-sectional survey (CoVAccS – wave 2) (2021)
Journal Article
Sherman, S., Sim, J., Cutts, M., Rubin, G., Sevdalis, N., Smith, L., Dasch, H., & Amlôt, R. (2022). COVID-19 vaccination acceptability in the UK at the start of the vaccination programme: a nationally representative cross-sectional survey (CoVAccS – wave 2). Public Health, 202, 1-9. https://doi.org/10.1016/j.puhe.2021.10.008

Objectives: To investigate factors associated with intention to have the COVID-19 vaccination following initiation of the UK national vaccination programme. Study Design: 1,500 adults completed an online cross-sectional survey (13th–15th January 2021... Read More about COVID-19 vaccination acceptability in the UK at the start of the vaccination programme: a nationally representative cross-sectional survey (CoVAccS – wave 2).