Gender-specific risk factors for gout: a systematic review of cohort studies (2019)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Hay, C. A., Mallen, C. D., & Roddy, E. (2019). Gender-specific risk factors for gout: a systematic review of cohort studies. Advances in Rheumatology, 59, Article 24. https://doi.org/10.1186/s42358-019-0067-7

BACKGROUND:
Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout. We aimed to systematically review all cohort studies examining risk factors for the development of gout by gend... Read More about Gender-specific risk factors for gout: a systematic review of cohort studies.

Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England (2019)
Journal Article
Mallen. (2019). Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England. Canadian Medical Association Journal, E680 - E688. https://doi.org/10.1503/cmaj.190178

BACKGROUND: Most patients with polymyalgia rheumatica or giant cell arteritis are treated with glucocorticoid therapy in primary care. We estimated dose-response risks of infection for this population in England.

METHODS: We conducted a retrospect... Read More about Incidence of infections associated with oral glucocorticoid dose in people diagnosed with polymyalgia rheumatica or giant cell arteritis: a cohort study in England.

2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. (2019)
Journal Article
Richette, P., Doherty, M., Pascual, E., Barskova, V., Becce, F., Castaneda, J., …Bardin, T. (2019). 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. Annals of the Rheumatic Diseases, 79(1), 31 - 38. https://doi.org/10.1136/annrheumdis-2019-215315

Although gout is the most common inflammatory arthritis, it is still frequently misdiagnosed. New data on imaging and clinical diagnosis have become available since the first EULAR recommendations for the diagnosis of gout in 2006. This prompted a sy... Read More about 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout..

Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. (2019)
Journal Article
Mallen, C., Roddy, E., Clarson, L., & Muller, S. (2019). Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. Canadian Medical Association Journal, 191(22), E597 - E603. https://doi.org/10.1503/cmaj.180717

BACKGROUND: Systemic inflammatory diseases have been associated with increased risk of venous thromboembolism. We aimed to quantify the risk of venous thromboembolism in patients with gout, the most common inflammatory arthritis, and to assess how di... Read More about Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy..

Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study (2019)
Journal Article
Protheroe, J., Saunders, B., Bartlam, B., Dunn, K., Cooper, V., Campbell, P., …Foster, N. (2019). Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-019-2587-z

Background
Musculoskeletal (MSK) pain represents a considerable worldwide healthcare burden. This study aimed to gain consensus from practitioners who work with MSK pain patients, on the most appropriate primary care treatment options for subgroups... Read More about Matching treatment options for risk sub-groups in musculoskeletal pain: a consensus groups study.

Is it time to screen for osteoarthritis? (2019)
Other
Mallen. (2019). Is it time to screen for osteoarthritis?

Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review (2019)
Journal Article
Mallen, Chew-Graham, & Mamas. (2019). Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review. Diabetic Medicine, 688-701. https://doi.org/10.1111/dme.13905

Aims
To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes.

Methods
We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data-based diabetes-... Read More about Assessing the Severity of Type 2 Diabetes Using Clinical Data Based Measures: a Systematic Review.

Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey (2019)
Journal Article
Hider, S. L., Muller, S., Helliwell, T., Prior, J. A., Scott, I., Lawton, S. A., …Mallen, C. D. (2019). Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey. Rheumatology, 58(11), 2009-2014. https://doi.org/10.1093/rheumatology/kez184

Objectives: To describe the prevalence of self-reported inflammatory joint symptoms, such as joint pain, stiffness and swelling in UK primary care patients consulting for both musculoskeletal (MSK) and non-musculoskeletal (non-MSK) complaints.

Met... Read More about Symptoms associated with inflammatory arthritis are common in the primary care population: results from the Joint Symptoms Survey.

Temporal relationships between systemic lupus erythematosus and comorbidities (2019)
Journal Article
Mallen. (2019). Temporal relationships between systemic lupus erythematosus and comorbidities. Rheumatology, 840-848. https://doi.org/10.1093/rheumatology/key335

Objective
To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality.

Methods
We identified 1605 incident cases of SLE and 6284 matched controls from the UK primary care. The risks of comorbidities... Read More about Temporal relationships between systemic lupus erythematosus and comorbidities.

Delays between the onset of symptoms and first rheumatology consultation in patients with rheumatoid arthritis in the UK: an observational study. (2019)
Journal Article
Jayne Stack, R., Nightingale, P., Jinks, C., Shaw, K., Herron-Marx, S., Horne, R., …Raza, K. (2019). Delays between the onset of symptoms and first rheumatology consultation in patients with rheumatoid arthritis in the UK: an observational study. BMJ Open, 9(3), Article e024361. https://doi.org/10.1136/bmjopen-2018-024361

OBJECTIVE: To investigate delays from symptom onset to rheumatology assessment for patients with a new onset of rheumatoid arthritis (RA) or unclassified arthritis. METHODS: Newly presenting adults with either RA or unclassified arthritis were recrui... Read More about Delays between the onset of symptoms and first rheumatology consultation in patients with rheumatoid arthritis in the UK: an observational study..

Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV. (2019)
Journal Article
Mallen. (2019). Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV. Rheumatology International, 285-291. https://doi.org/10.1007/s00296-018-4188-9

There are no data from West Africa reporting musculoskeletal (MSK) disease in people living with HIV (PLWH). Our primary outcome was to measure the prevalence of MSK symptoms in PLWH in urban West Africa. Our secondary outcomes were to describe the d... Read More about Musculoskeletal symptoms and non-prescribed treatments are common in an urban African population of people living with HIV..

How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study (2019)
Journal Article
Holden, M. A., Waterfield, J., Whittle, R., Bennell, K., Quicke, J. G., Chesterton, L., & Mallen, C. (2019). How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study. Musculoskeletal Care, 17(1), 133-144. https://doi.org/10.1002/msc.1383

BACKGROUND
Weight loss is recommended as a core treatment for individuals with hip osteoarthritis who are overweight or obese. Physiotherapists play an important role in managing patients with hip osteoarthritis, but little is known about how they a... Read More about How do UK physiotherapists address weight loss among individuals with hip osteoarthritis? A mixed-methods study.

The emerging role of physiotherapists in the management of people with Polymyalgia Rheumatica; findings from a UK qualitative study (2019)
Journal Article
O'Brien, A., Muller, S., Liddle, J., Thomas, M., & Mallen, C. (2019). The emerging role of physiotherapists in the management of people with Polymyalgia Rheumatica; findings from a UK qualitative study. Physiotherapy, e178 - e179. https://doi.org/10.1016/j.physio.2018.11.187

Development and validation of a clinical rule for recognition of early inflammatory arthritis (2018)
Journal Article
Mallen, C., & Hider, S. (2018). Development and validation of a clinical rule for recognition of early inflammatory arthritis. BMJ Open, https://doi.org/10.1136/bmjopen-2018-023552

Objectives
National and international guidelines recommend prompt referral of patients presenting with inflammatory arthritis (IA), but general practitioners (GPs) feel uncertain in their proficiency to detect synovitis through joint examination, th... Read More about Development and validation of a clinical rule for recognition of early inflammatory arthritis.

Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care (2018)
Journal Article
Mallen, Roddy, & Muller. (2018). Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care. Arthritis Care and Research, 1822-1828. https://doi.org/10.1002/acr.23562

Objective
To examine the association between gout severity and socioeconomic status (SES) and gout severity and work absence.

Methods
Postal questionnaires were sent to adult patients who were registered with 20 general practices and who had co... Read More about Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care.

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article
Mallen, Roddy, Belcher, Clarson, & Muller. (2018). Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study. Arthritis Research and Therapy, 20, Article 243. https://doi.org/10.1186/s13075-018-1746-1

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice (2018)
Journal Article
Hider, S., Lawton, S., Muller, S., Helliwell, T., Zwierska, I., Mallen, C., & Richardson, J. (2018). Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice. British Journal of General Practice (BJGP), 68(676), E783-E793. https://doi.org/10.3399/bjgp18X699557

BACKGROUND: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older individuals. Most patients with PMR are diagnosed and managed exclusively in general practice, yet primary care-focused research is lack... Read More about Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice.

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., Edwards, J. J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Objectives
The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate two models... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. (2018)
Journal Article
Mallen. (2018). Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. BMJ Open, e022205 - ?. https://doi.org/10.1136/bmjopen-2018-022205

INTRODUCTION: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness of a physiotherapist-deliver... Read More about Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol..

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Mallen. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives
To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination.

Methods
From the Clinical Practice Research Datalink, 32 751 people with auto-i... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.