Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. (2020)
Journal Article
Brooks, J., Everett, J., Lermyte, F., Tjendana Tjhin, V., Sadler, P. J., Telling, N., & Collingwood, J. F. (2020). Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. Journal of Trace Elements in Medicine and Biology, 62, Article 126555. https://doi.org/10.1016/j.jtemb.2020.126555

BACKGROUND: Neuromelanin-pigmented neurons, which are highly susceptible to neurodegeneration in the Parkinson's disease substantia nigra, harbour elevated iron levels in the diseased state. Whilst it is widely believed that neuronal iron is stored i... Read More about Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy..

Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. (2020)
Journal Article
Telling, & Everett. (2020). Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202000239

A hallmark of Parkinson's disease is the death of neuromelanin-pigmented neurons, but the role of neuromelanin is unclear. The in situ characterization of neuromelanin remains dependent on detectable pigmentation, rather than direct quantification of... Read More about Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy..

Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer’s disease subjects (2018)
Journal Article
Everett, J., Collingwood, J. F., Tjendana-Tjhin, V., Brooks, J., Lermyte, F., Plascencia-Villa, G., …Telling, N. D. (2018). Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer’s disease subjects. Nanoscale, 10(25), 11782-11796. https://doi.org/10.1039/c7nr06794a

Altered metabolism of biometals in the brain is a key feature of Alzheimer's disease, and biometal interactions with amyloid-ß are linked to amyloid plaque formation. Iron-rich aggregates, including evidence for the mixed-valence iron oxide magnetite... Read More about Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer’s disease subjects.

Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease. (2017)
Journal Article
Telling, N., Everett, J., Collingwood, J. F., Dobson, J., van der Laan, G., Gallagher, J. J., …Hitchcock, A. P. (2017). Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease. Cell chemical biology, 24(10), 1205-1215. https://doi.org/10.1016/j.chembiol.2017.07.014

A signature characteristic of Alzheimer's disease (AD) is aggregation of amyloid-beta (Aß) fibrils in the brain. Nevertheless, the links between Aß and AD pathology remain incompletely understood. It has been proposed that neurotoxicity arising from... Read More about Iron Biochemistry is Correlated with Amyloid Plaque Morphology in an Established Mouse Model of Alzheimer's Disease..