The clinical characteristics, managements, and outcomes of acute myocardial infarction in osteoarthritis patients; a cross-sectional analysis of 6.5 million patients. (2024)
Journal Article
Parmar, S. S., Mohamed, M. O., Mamas, M. A., & Wilkie, R. (in press). The clinical characteristics, managements, and outcomes of acute myocardial infarction in osteoarthritis patients; a cross-sectional analysis of 6.5 million patients. Expert Review of Cardiovascular Therapy, 22(1-3), 1-9. https://doi.org/10.1080/14779072.2024.2311696

The prevalence of osteoarthritis (OA) and cardiovascular disease are increasing and both conditions share similar risk factors. We investigated the association between OA and receipt of invasive managements and clinical outcomes in patients with acut... Read More about The clinical characteristics, managements, and outcomes of acute myocardial infarction in osteoarthritis patients; a cross-sectional analysis of 6.5 million patients..

Persistent inequalities in consultation incidence and prevalence of low back pain and osteoarthritis in England between 2004-2019 (2022)
Journal Article
Yu, D., Jordan, K. P., Wilkie, R., Bailey, J., Fitzpatrick, J., Ali, N., …Peat, G. (2022). Persistent inequalities in consultation incidence and prevalence of low back pain and osteoarthritis in England between 2004-2019. Rheumatology Advances in Practice, 7(1), https://doi.org/10.1093/rap/rkac106

Objective
To determine whether socioeconomic inequalities in primary care consultation rates for two major, disabling musculoskeletal conditions in England narrowed or widened between 2004-2019.

Methods
We analysed data from Clinical Practice Re... Read More about Persistent inequalities in consultation incidence and prevalence of low back pain and osteoarthritis in England between 2004-2019.

Do recommended interventions widen or narrow inequalities in musculoskeletal health? An equity-focussed systematic review of differential effectiveness (2022)
Journal Article
Peat, G., Jordan, K., Wilkie, R., Corp, N., Van Der Windt, D., Yu, D., …Ali, N. (2022). Do recommended interventions widen or narrow inequalities in musculoskeletal health? An equity-focussed systematic review of differential effectiveness. Journal of Public Health, 44(3), e376–e387. https://doi.org/10.1093/pubmed/fdac014

Background It is unclear whether seven interventions recommended by Public Health England for preventing and managing common musculoskeletal conditions reduce or widen health inequalities in adults with musculoskeletal conditions. Methods We used cit... Read More about Do recommended interventions widen or narrow inequalities in musculoskeletal health? An equity-focussed systematic review of differential effectiveness.

Trends in the Annual Consultation Incidence and Prevalence of Low Back Pain and Osteoarthritis in England from 2000 to 2019: Comparative Estimates from Two Clinical Practice Databases (2022)
Journal Article
Yu, D., Missen, M., P Jordan, K., Edwards, J., Bailey, J., Wilkie, R., …Peat, G. (2022). Trends in the Annual Consultation Incidence and Prevalence of Low Back Pain and Osteoarthritis in England from 2000 to 2019: Comparative Estimates from Two Clinical Practice Databases. Clinical Epidemiology, 14, 179-189. https://doi.org/10.2147/CLEP.S337323

Purpose: To compare estimates of annual person-consulting incidence and prevalence of low back pain (LBP) and osteoarthritis for two national English electronic health record databases (Clinical Practice Research Datalink (CPRD) Aurum and CPRD GOLD).... Read More about Trends in the Annual Consultation Incidence and Prevalence of Low Back Pain and Osteoarthritis in England from 2000 to 2019: Comparative Estimates from Two Clinical Practice Databases.

Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations (2022)
Journal Article
Lynch, M., Bucknall, M., Jagger, C., & Wilkie, R. (2022). Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations. Scientific reports, 12(1), Article 2408. https://doi.org/10.1038/s41598-022-06490-3

Retirement ages are rising in many countries to offset the challenges of population ageing, but osteoarthritis is an age-associated disease that is becoming more prevalent and may limit capacity to work until older ages. We aimed to assess the impact... Read More about Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations.

496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis (2021)
Journal Article
Huang, M., Yu, D., Wilkie, R., & Mamas, M. (2021). 496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis. International Journal of Epidemiology, i105 - i105. https://doi.org/10.1093/ije/dyab168.295

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Osteoarthritis (OA) has a major impact on the global burden of disease and is associated with poorer cardiovascular disease (CVD) outcomes. However it’s unclear... Read More about 496Higher predicted 10-year risk for cardiovascular disease in primary care consulters for osteoarthritis.

Estimating the population health burden of musculoskeletal conditions using primary care electronic health records (2021)
Journal Article
Yu, D., Peat, G., Jordan, K., Bailey, J., Prieto-Alhambra, D., Robinson, D., …Wilkie, R. (2021). Estimating the population health burden of musculoskeletal conditions using primary care electronic health records. Rheumatology, 60(10), 4832-4843. https://doi.org/10.1093/rheumatology/keab109

Objectives
Better indicators from affordable, sustainable data sources are needed to monitor population burden of musculoskeletal conditions. We propose five indicators of musculoskeletal health and assessed if routinely available primary care elect... Read More about Estimating the population health burden of musculoskeletal conditions using primary care electronic health records.

The association between osteoarthritis and invasive treatment and clinical outcomes in 6.5 million patients presenting with acute myocardial infarction (2020)
Journal Article
Parmar, S., Mohamed, M., Wilkie, R., & Mamas, M. (2020). The association between osteoarthritis and invasive treatment and clinical outcomes in 6.5 million patients presenting with acute myocardial infarction. European Heart Journal, 41(S2), 1660 - 1660. https://doi.org/10.1093/ehjci/ehaa946.1660

Background
People with osteoarthritis (OA) have an increased risk of cardiovascular disease, including acute myocardial infarction (AMI). Despite OA being the most common joint condition and the fastest increasing major health condition, there is li... Read More about The association between osteoarthritis and invasive treatment and clinical outcomes in 6.5 million patients presenting with acute myocardial infarction.

Reasons why osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model (2019)
Journal Article
Wilkie, R., Singh Parmar, S., Blagojevic-Bucknall, M., Smith, D., Thomas, M. J., Seale, B. J., …Peat, G. (2019). Reasons why osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model. RMD Open, 5(2), Article e001048. https://doi.org/10.1136/rmdopen-2019-001048

Objectives: To identify potentially modifiable factors that mediate the association between symptomatic osteoarthritis (OA) and premature mortality. Methods: A population-based prospective cohort study; primary care medical record data were linked to... Read More about Reasons why osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model.

Why so Fast? A Focus on Reasons for an Increase in Arthritis-Attributable Activity Limitation Trends, 2002-2017 (2019)
Presentation / Conference
Theis, K., Boring, M., & Wilkie, R. (2019, November). Why so Fast? A Focus on Reasons for an Increase in Arthritis-Attributable Activity Limitation Trends, 2002-2017. Poster presented at 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA

Background/Purpose: “Arthritis-attributable activity limitation” (AAAL) is linked to many potentially modifiable characteristics (e.g., work disability, physical inactivity, obesity). By 2015, prevalence of AAAL among adults =18 with arthritis had in... Read More about Why so Fast? A Focus on Reasons for an Increase in Arthritis-Attributable Activity Limitation Trends, 2002-2017.

TARGETS FOR REDUCING PREMATURE MORTALITY IN OLDER ADULTS WITH OSTEOARTHRITIS: RESULTS FROM A NOVEL PATH ANALYSIS WITHIN A COX PROPORTIONAL HAZARDS MODEL (2019)
Journal Article
Wilkie, R., Parmar, S., & Bucknall, M. (2019). TARGETS FOR REDUCING PREMATURE MORTALITY IN OLDER ADULTS WITH OSTEOARTHRITIS: RESULTS FROM A NOVEL PATH ANALYSIS WITHIN A COX PROPORTIONAL HAZARDS MODEL. Annals of the Rheumatic Diseases, 78-S2, 152 - 153. https://doi.org/10.1136/annrheumdis-2019-eular.5862

Objectives The objectives of this study were to identify potential mechanisms of the impact of osteoarthritis on mortality and examine the role of modifiable targets (anxiety, depression, insomnia and walking frequency) for health professionals in rh... Read More about TARGETS FOR REDUCING PREMATURE MORTALITY IN OLDER ADULTS WITH OSTEOARTHRITIS: RESULTS FROM A NOVEL PATH ANALYSIS WITHIN A COX PROPORTIONAL HAZARDS MODEL.

SOCIAL HEALTH PROFILES IN PRIMARY CARE CONSULTERS FOR COMMON MUSCULOSKELETAL CONDITIONS: OPERATIONALISATION OF THE PROMIS SHORT FORM TOOL IN PATIENTS WITH MUSCULOSKELETAL CONDITIONS (2019)
Journal Article
Uraiby, Y., & Wilkie, R. (2019). SOCIAL HEALTH PROFILES IN PRIMARY CARE CONSULTERS FOR COMMON MUSCULOSKELETAL CONDITIONS: OPERATIONALISATION OF THE PROMIS SHORT FORM TOOL IN PATIENTS WITH MUSCULOSKELETAL CONDITIONS. Rheumatology, 58(S3), Article kez107.023. https://doi.org/10.1093/rheumatology/kez107.023

Reasons for retirement in older adults with osteoarthritis (2019)
Journal Article
Walters, B., & Wilkie, R. (2019). Reasons for retirement in older adults with osteoarthritis. Rheumatology, 58(S3), 107 - 107. https://doi.org/10.1093/rheumatology/kez108.068

Background: Osteoarthritis begins to emerge as a major cause of functional limitation, work disability and retirement from age 50 years onwards. With policies encouraging extensions to working life, older workers with osteoarthritis will be expected... Read More about Reasons for retirement in older adults with osteoarthritis.

OSTEOARTHRITIS AND PREMATURE MORTALITY: PATHWAYS FOR HAND, HIP, KNEE AND FOOT OSTEOARTHRITIS (2019)
Journal Article
Seale, B., Thomas, M., Parmar, S., Blagojevic-Bucknall, M., & Wilkie, R. (2019). OSTEOARTHRITIS AND PREMATURE MORTALITY: PATHWAYS FOR HAND, HIP, KNEE AND FOOT OSTEOARTHRITIS. Rheumatology, 58(S3), Article kez108.062. https://doi.org/10.1093/rheumatology/kez108.062

The impact of socioeconomic status on the link between osteoarthritis and the onset of common comorbidities (2019)
Journal Article
Wilkie, R., Kaur, K., & Hayward, R. A. (2019). The impact of socioeconomic status on the link between osteoarthritis and the onset of common comorbidities. Clinical and Experimental Rheumatology, 37(1), 44-48

Objectives The temporal relationship between osteoarthritis and comorbidity is unclear and may vary with socioeconomic status. The aims of this study were to identify if osteoarthritis was associated with onset of common comorbidities, and if the ass... Read More about The impact of socioeconomic status on the link between osteoarthritis and the onset of common comorbidities.

Secular trends in work disability and its relationship to musculoskeletal pain and mental health: a time-trend analysis using five cross-sectional surveys (2002-2010) in the general population. (2018)
Journal Article
Wynne-Jones, G., Chen, Y., Croft, P., Peat, G., Wilkie, R., Jordan, K., & Petersson, I. F. (2018). Secular trends in work disability and its relationship to musculoskeletal pain and mental health: a time-trend analysis using five cross-sectional surveys (2002-2010) in the general population. Occupational and Environmental Medicine, 877-883. https://doi.org/10.1136/oemed-2018-105171

OBJECTIVES: International evidence suggests that rates of inability to work because of illness can change over time. We hypothesised that one reason for this is that the link between inability to work and common illnesses, such as musculoskeletal pai... Read More about Secular trends in work disability and its relationship to musculoskeletal pain and mental health: a time-trend analysis using five cross-sectional surveys (2002-2010) in the general population..

Pain and mortality: mechanisms for a relationship (2018)
Journal Article
Smith, D., Wilkie, R., Croft, P., Parmar, S., & McBeth, J. (2018). Pain and mortality: mechanisms for a relationship. PAIN, 1112 -1118. https://doi.org/10.1097/j.pain.0000000000001193

Moderate to severe chronic pain affects 1 in 5 adults and its impact increases with age. People with chronic pain that interferes with their lives have an increased risk of mortality. Identifying how interfering chronic pain can lead to mortality may... Read More about Pain and mortality: mechanisms for a relationship.

The role of environmental factors for the onset of restricted mobility outside the home among older adults with osteoarthritis: a prospective cohort study (2017)
Journal Article
Rantakokko, M., & Wilkie, R. (2017). The role of environmental factors for the onset of restricted mobility outside the home among older adults with osteoarthritis: a prospective cohort study. BMJ Open, 7(6), e012826 -?. https://doi.org/10.1136/bmjopen-2016-012826

OBJECTIVES: The study examines how environmental factors contribute to the onset of restricted mobility outside the home among older adults with osteoarthritis. METHODS: This is a prospective cohort study of adults aged 50 years and older with osteoa... Read More about The role of environmental factors for the onset of restricted mobility outside the home among older adults with osteoarthritis: a prospective cohort study.

The onset of widespread musculoskeletal pain is associated with a decrease in healthy ageing in older people: a population-based prospective study (2013)
Journal Article
Wilkie, R., Tajar, A., & McBeth, J. (2013). The onset of widespread musculoskeletal pain is associated with a decrease in healthy ageing in older people: a population-based prospective study. PloS one, 8(3), e59858 - ?. https://doi.org/10.1371/journal.pone.0059858

OBJECTIVE: Chronic musculoskeletal pain is common in older adults but the nature of its relationship with ageing is unclear. The objective for this study was to test the hypothesis that the onset of widespread pain would be associated with a decrease... Read More about The onset of widespread musculoskeletal pain is associated with a decrease in healthy ageing in older people: a population-based prospective study.