True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study? (2019)
Journal Article
Mamas. (2019). True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study?. BMJ, https://doi.org/10.1136/bmj.l729

OBJECTIVE
To determine the distribution, and specifically the true 99th centile, of high sensitivity cardiac troponin I
(hs-cTnI) for a whole hospital population by applying the hs-cTnI assay currently used routinely at a large
teaching hospital.... Read More about True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study?.

Point-of-care measurements reveal release of purines into venous blood of stroke patients (2019)
Journal Article
Roffe. (2019). Point-of-care measurements reveal release of purines into venous blood of stroke patients. Purinergic Signalling, 237-246. https://doi.org/10.1007/s11302-019-09647-4

Stroke is a leading cause of death and disability. Here, we examine whether point-of-care measurement of the purines, adenosine, inosine and hypoxanthine, which are downstream metabolites of ATP, has potential to assist the diagnosis of stroke. In a... Read More about Point-of-care measurements reveal release of purines into venous blood of stroke patients.

“Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step. (2019)
Journal Article
Philp, F., Leboeuf, F., Pandyan, A., & Stewart, C. (2019). “Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step. Gait and Posture, 70, 298-304. https://doi.org/10.1016/j.gaitpost.2019.03.006

Background
Dynamic “knee valgus” has been identified as a risk factor for significant knee injuries, however, the limits and sources of error associated with existing 3D motion analysis methods have not been well established.

Research question
W... Read More about “Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step..

PCSK9 Inhibitors in Diabetic Dyslipidemia (2019)
Book Chapter
(2019). PCSK9 Inhibitors in Diabetic Dyslipidemia. In RSSDI Diabetes Update 2018 (374-378). https://doi.org/10.5005/jp/books/18092_77

The association between cardiovascular disease (CVD) risk and raised serum total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) has been demonstrated in epidemiology1 and intervention trials showing significant decreases in CVD foll... Read More about PCSK9 Inhibitors in Diabetic Dyslipidemia.

Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death (2019)
Journal Article
Lambie, M., Teece, L., Johnson, D. W., Petrie, M., Mactier, R., Solis-Trapala, I., Belcher, J., Bekker, H. L., Wilkie, M., Tupling, K., Phillips-Darby, L., & Davies, S. J. (2019). Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death. Nephrology Dialysis Transplantation, 1585-1591. https://doi.org/10.1093/ndt/gfz034

Background
Risk of Encapsulating Peritoneal Sclerosis (EPS) is strongly associated with the duration of peritoneal dialysis (PD), such that patients who have been on PD for some time may consider elective transfer to haemodialysis to mitigate risk o... Read More about Estimating risk of encapsulating peritoneal sclerosis accounting for the competing risk of death.

International Variations in Peritoneal Dialysis Utilization and Implications for Practice (2019)
Journal Article
Davies. (2019). International Variations in Peritoneal Dialysis Utilization and Implications for Practice. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2018.12.033

In many countries, the use of peritoneal dialysis (PD) remains low despite arguments that support its greater use, including dialysis treatment away from hospital settings, avoidance of central venous catheters, and potential health economic advantag... Read More about International Variations in Peritoneal Dialysis Utilization and Implications for Practice.

Early readmissions after isolated coronary artery bypass grafting. (2019)
Journal Article
Mamas. (2019). Early readmissions after isolated coronary artery bypass grafting. International Journal of Clinical Practice, e13319 - ?. https://doi.org/10.1111/ijcp.13319

Since its introduction, coronary artery bypass grafting (CABG) has been the revascularisation intervention of choice in patients with complex coronary artery disease [1]. CABG is the most common cardiac surgical procedure [3]. Those reshospitalised w... Read More about Early readmissions after isolated coronary artery bypass grafting..

Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction (2019)
Journal Article
Mamas. (2019). Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction. Heart, 315-321. https://doi.org/10.1136/heartjnl-2018-313671

Background
Discharge against medical advice (AMA) occurs infrequently but is associated with poor outcomes. There are limited descriptions of discharges AMA in national cohorts of patients with acute myocardial infarction (AMI). This study aims to e... Read More about Discharge Against Medical Advice after Hospitalization for Acute Myocardial Infarction.

Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction (2019)
Journal Article
Mamas. (2019). Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction. European Heart Journal: Acute Cardiovascular Care, 68-77. https://doi.org/10.1177/2048872617710790

Background:
High survival rates are commonly reported following primary percutaneous coronary intervention for ST-elevation myocardial infarction, with most contemporary studies reporting overall survival.

Aims:
The aim of this study was to d... Read More about Relative survival and excess mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction.

Local solutions save young lives. (2019)
Journal Article
Davies. (2019). Local solutions save young lives. Nature Reviews Nephrology, 127-128. https://doi.org/10.1038/s41581-018-0109-0

Peritoneal dialysis has many advantages over haemodialysis in the treatment of acute kidney injury (AKI) in low-resource settings. One limitation, however, is the availability of commercial dialysis fluid. Following the International Society of Perit... Read More about Local solutions save young lives..

The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life (2018)
Journal Article
(2019). The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life. Seminars in Arthritis and Rheumatism, 49(1), 20-26. https://doi.org/10.1016/j.semarthrit.2018.12.006

Objective
Treat-to-target in rheumatoid arthritis (RA) recommends targeting remission, with low disease activity (LDA) being an alternative goal. When deciding to target remission or LDA, important considerations are the likelihood of attaining them... Read More about The frequency of remission and low disease activity in patients with rheumatoid arthritis, and their ability to identify people with low disability and normal quality of life.

Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database (2018)
Journal Article
Mamas. (2018). Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database. JACC. Cardiovascular interventions, 2480-2491. https://doi.org/10.1016/j.jcin.2018.09.035

Objectives
Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected left main stem percutaneou... Read More about Access site and outcomes for unprotected left main stem PCI: an analysis of the British Cardiovascular Intervention Society database.

Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation (2018)
Journal Article
Mamas. (2018). Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation. Heart, 2058-2066. https://doi.org/10.1136/heartjnl-2018-313356

OBJECTIVES
To investigate the association of the CharlsonComorbidity Index (CCI) with clinical outcomes after transcatheter aortic valve implantation (TAVI).

BACKGROUND: Patients undergoing TAVI have high comorbid burden; however, there is limite... Read More about Association of comorbid burden with clinical outcomes after transcatheter aortic valve implantation.

Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility? (2018)
Journal Article
Davies. (2018). Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?. Kidney International, 1050 -1052. https://doi.org/10.1016/j.kint.2018.09.012

Peritoneal dialysis technique survival remains challenging due to peritonitis and long-term alterations to peritoneal membrane function and integrity. Up to now, the development of less bio-incompatible dialysis solutions have not had a major impact... Read More about Does alanyl-glutamine supplementation offer potential to improve peritoneal dialysate biocompatibility?.

Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis (2018)
Journal Article
Wong, C., Kwok, C., Narain, A., Gulati, M., Mihalidou, A., Wu, P., Alasnag, M., Myint, P., & Mamas, M. (2018). Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis. Heart, 1937-1948. https://doi.org/10.1136/heartjnl-2018-313005

Background The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD.... Read More about Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis.

Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts (2018)
Journal Article
Shoaib, A., Kinnaird, T., Curzen, N., Kontopantelis, E., Ludman, P., de Belder, M., Rashid, M., Shing Kwok, C., Nolan, J., Zaman, A., & Mamas, M. (2018). Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts. Circulation: Cardiovascular Interventions, 11(11), https://doi.org/10.1161/circinterventions.118.006824

Background: There are limited data on outcomes of patients with previous CABG presenting with NSTEMI undergoing PCI. We compare clinical characteristics and outcomes in NSTEMI patients undergoing PCI with or without prior CABG surgery in a national c... Read More about Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts.

Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review (2018)
Journal Article
Ayyaz Ul Haq, M., Rashid, M., Gilchrist, I. C., Bertrand, O., Shing Kwok, C., Wai Wong, C., Mansour, H. M., Baghdaddy, Y., Nolan, J., van Leeuwen, M. A., & Mamas, M. A. (2018). Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review. Circulation Journal, 82(11), 2736. https://doi.org/10.1253/circj.CJ-18-0389

Background

We sought to systematically review the available literature on limb dysfunction after transradial or transfemoral cardiac catheterization.

Methods & Results
MEDLINE and EMBASE were searched for studies evaluating any transradial or... Read More about Incidence and clinical course of limb dysfunction post cardiac catheterization: a systematic review.

Pre-Procedural Risk Models for Patients Undergoing Transcatheter Aortic Valve Implantation (2018)
Journal Article
Mamas. (2018). Pre-Procedural Risk Models for Patients Undergoing Transcatheter Aortic Valve Implantation. Journal of thoracic disease, https://doi.org/10.21037/jtd.2018.05.67

Transcatheter aortic valve implantation (TAVI) has emerged as the standard treatment option for patients with symptomatic aortic stenosis who are considered intermediate to high surgical risk. Nonetheless, optimal clinical outcomes following the proc... Read More about Pre-Procedural Risk Models for Patients Undergoing Transcatheter Aortic Valve Implantation.

Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy. (2018)
Journal Article
Kadam, U. T., Roberts, I., White, S., Bednall, R., Khunti, K., Nilsson, P. M., & Lawson, C. A. (2019). Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy. Journal of Clinical Epidemiology, 106, 98-107. https://doi.org/10.1016/j.jclinepi.2018.10.014

With older and ageing populations, patients experience multiple chronic diseases at the same time. Individual chronic disease guidelines often recommend pharmacological therapies as a key intervention, resulting in patients being prescribed multiple... Read More about Conceptualising multiple drug use in patients with comorbidity and multimorbidity: proposal for standard definitions beyond the term polypharmacy..

Transradial Approach for Left Ventricular Endomyocardial Biopsy (2018)
Journal Article
Mamas. (2018). Transradial Approach for Left Ventricular Endomyocardial Biopsy. Canadian Journal of Cardiology, 1283-1288. https://doi.org/10.1016/j.cjca.2018.05.007

Background
Left ventricular endomyocardial biopsy (LV-EMB) may offer a superior diagnostic yield compared with right ventricular endomyocardial biopsy (RV-EMB) in conditions predominantly affecting the LV but is underused compared with RV-EMB. Despi... Read More about Transradial Approach for Left Ventricular Endomyocardial Biopsy.