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Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression (1996)
Journal Article
Sarhanis, P., Redman, C., Perrett, C., Brannigan, K., Clayton, R., Hand, P., Musgrove, C., Suarez, V., Jones, P., Fryer, A., Farrell, W., & Strange, R. (1996). Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression. British journal of cancer, 1757 - 1761. https://doi.org/10.1038/bjc.1996.626

The importance of polymorphism in the glutathione S-transferase GSTM1, GSTT1 and, cytochrome P450, CYP2D6 loci in the pathogenesis of epithelial ovarian cancer has been assessed in two studies; firstly, a case-control study designed to determine the... Read More about Epithelial ovarian cancer: influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression.

Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. (1995)
Journal Article
Duncan, H., Swanx, C., Green, J., Jones, P., Brannigan, K., Alldersea, J., Fryer, A. A., & Strange, R. C. (1995). Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes. Clinica Chimica Acta, 240(1), 53-61. https://doi.org/10.1016/0009-8981%2895%2906127-4

The polymorphic glutathione S-transferase GSTM1 and GSTT1 loci are attractive candidates for susceptibility to ulcerative colitis and Crohn's disease because their enzymes catalyse the detoxification of products of oxidative stress and tobacco-derive... Read More about Susceptibility to ulcerative colitis and Crohn's disease: interactions between glutathione S-transferase GSTM1 and GSTT1 genotypes..

Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery
Presentation / Conference
Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery. Presented at BJGP Research Conference

Background In the UK 5.4 million people receive treatment for asthma. Patients diagnosed with asthma should not be prescribed a long-acting muscarinic antagonist (LAMA), or a long-acting beta 2 agonist (LABA) without co-prescription of an inhaled cor... Read More about Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery.

Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation
Thesis
Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation. https://keele-repository.worktribe.com/output/423983

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting approximately 1% of the population. The life expectancy of those with RA is reduced, mainly due to an increased risk of cardiovascular disease (CVD). This thesis investi... Read More about Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation.

The positive predictive value of postmenopausal bleeding for uterine malignancy
Thesis
The positive predictive value of postmenopausal bleeding for uterine malignancy. https://keele-repository.worktribe.com/output/423984

Postmenopausal bleeding (PMB) is vaginal bleeding occurring after the menopause. The differing definitions of PMB used and need for a standard definition, including what this might be, are highlighted in the thesis. Benign and malignant causes of PMB... Read More about The positive predictive value of postmenopausal bleeding for uterine malignancy.

Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis
Thesis
Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis. https://keele-repository.worktribe.com/output/423987

Aim: This thesis explores the complex cellular and biological interrelationships involved in Idiopathic Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis. Methods and results: 21 IPF and 19 control lung tissues were... Read More about Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis.

STarTBack Whiteboard
Digital Artefact
STarTBack Whiteboard

Video evidence support for Impact on REF.

EULAR School of Rheumatology
Digital Artefact
Roddy. EULAR School of Rheumatology

(5.10) European League Against Rheumatism (EULAR) - Online video evidence for REF21

Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes
Thesis
Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes. https://keele-repository.worktribe.com/output/418484

Recent study suggested that the anti-platelet effect of nicergoline is caused by inhibiting agonist-evoked Ca2+ signalling by disrupting the normal localization of the dense tubular system in human platelets. This effect is brought about by the disru... Read More about Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes.

An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells
Thesis
An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells. https://keele-repository.worktribe.com/output/418482

Type 1 diabetes is a challenging condition to manage effectively. Utilising the mesenchymal stem cell (MSC) secretome is an avenue being researched in regenerative medicine which could potentially ameliorate the condition. Previous studies have ident... Read More about An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells.

Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis
Thesis
Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis. https://keele-repository.worktribe.com/output/418483

Distal intestinal obstruction syndrome (DIOS) is a major gastrointestinal complication in cystic fibrosis (CF). It arises when thick mucus and viscid faecal material combine in the bowel, commonly at the terminal ileum or caecum, leading to partial o... Read More about Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis.

Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48
Journal Article
Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48. https://doi.org/10.7243/2050-0866-4-4

Background: IAPP1-37 and ProIAPP1-48 are amyloidogenic peptides implicated in ß-cell death in diabetes. Interactions with metals may be involved in both the cytotoxicity of these peptides and their deposition as amyloids associated with diabetes-rela... Read More about Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48.

An epidemiological study of self-care restriction and joint pain in community-dwelling older people
Thesis
An epidemiological study of self-care restriction and joint pain in community-dwelling older people. https://keele-repository.worktribe.com/output/409109

Self-care restriction is proposed in the World Health Organization’s International Classification of Functioning (ICF) as an important functional consequence of health conditions. In contrast to traditional approaches which focus only on an individua... Read More about An epidemiological study of self-care restriction and joint pain in community-dwelling older people.

Clinical validation of near-patient assessment of fluid status in dialysis patients
Thesis
Tan, B. K. Clinical validation of near-patient assessment of fluid status in dialysis patients. https://keele-repository.worktribe.com/output/408050

Dialysis patients have an extraordinarily high level of cardiovascular morbidity and mortality. Volume expansion is common among this cohort and this is linked to markers of cardiac dysfunction, inflammation and low plasma albumin, all of which predi... Read More about Clinical validation of near-patient assessment of fluid status in dialysis patients.