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Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery
Presentation / Conference
Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery. Presented at BJGP Research Conference

Background In the UK 5.4 million people receive treatment for asthma. Patients diagnosed with asthma should not be prescribed a long-acting muscarinic antagonist (LAMA), or a long-acting beta 2 agonist (LABA) without co-prescription of an inhaled cor... Read More about Identifying and rectifying prescriptions of long-acting antimuscarinic and beta-agonist inhalers without inhaled corticosteroids to asthma patients: an audit from a UK general practice surgery.

Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation
Thesis
(2013). Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting approximately 1% of the population. The life expectancy of those with RA is reduced, mainly due to an increased risk of cardiovascular disease (CVD). This thesis investi... Read More about Screening for cardiovascular disease in Rheumatoid Arthritis: a records-based investigation.

The positive predictive value of postmenopausal bleeding for uterine malignancy
Thesis
(2013). The positive predictive value of postmenopausal bleeding for uterine malignancy

Postmenopausal bleeding (PMB) is vaginal bleeding occurring after the menopause. The differing definitions of PMB used and need for a standard definition, including what this might be, are highlighted in the thesis. Benign and malignant causes of PMB... Read More about The positive predictive value of postmenopausal bleeding for uterine malignancy.

Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis
Thesis
(2013). Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis

Aim: This thesis explores the complex cellular and biological interrelationships involved in Idiopathic Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis. Methods and results: 21 IPF and 19 control lung tissues were... Read More about Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis.

STarTBack Whiteboard
Digital Artefact
(2021). STarTBack Whiteboard

Video evidence support for Impact on REF.

EULAR School of Rheumatology
Digital Artefact
Roddy. EULAR School of Rheumatology

(5.10) European League Against Rheumatism (EULAR) - Online video evidence for REF21

Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes
Thesis
(2017). Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes

Recent study suggested that the anti-platelet effect of nicergoline is caused by inhibiting agonist-evoked Ca2+ signalling by disrupting the normal localization of the dense tubular system in human platelets. This effect is brought about by the disru... Read More about Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes.

An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells
Thesis
(2017). An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells

Type 1 diabetes is a challenging condition to manage effectively. Utilising the mesenchymal stem cell (MSC) secretome is an avenue being researched in regenerative medicine which could potentially ameliorate the condition. Previous studies have ident... Read More about An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells.

Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis
Thesis
(2017). Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis

Distal intestinal obstruction syndrome (DIOS) is a major gastrointestinal complication in cystic fibrosis (CF). It arises when thick mucus and viscid faecal material combine in the bowel, commonly at the terminal ileum or caecum, leading to partial o... Read More about Interventions for the Management of Distal Intestinal Obstruction Syndrome in Cystic Fibrosis.

Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48
Journal Article
(2015). Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48. https://doi.org/10.7243/2050-0866-4-4

Background: IAPP1-37 and ProIAPP1-48 are amyloidogenic peptides implicated in ß-cell death in diabetes. Interactions with metals may be involved in both the cytotoxicity of these peptides and their deposition as amyloids associated with diabetes-rela... Read More about Further insight into the role of metals in amyloid formation by IAPP1-37 and ProIAPP1-48.

An epidemiological study of self-care restriction and joint pain in community-dwelling older people
Thesis
(2013). An epidemiological study of self-care restriction and joint pain in community-dwelling older people

Self-care restriction is proposed in the World Health Organization’s International Classification of Functioning (ICF) as an important functional consequence of health conditions. In contrast to traditional approaches which focus only on an individua... Read More about An epidemiological study of self-care restriction and joint pain in community-dwelling older people.

Clinical validation of near-patient assessment of fluid status in dialysis patients
Thesis
Tan, B. K. (2017). Clinical validation of near-patient assessment of fluid status in dialysis patients

Dialysis patients have an extraordinarily high level of cardiovascular morbidity and mortality. Volume expansion is common among this cohort and this is linked to markers of cardiac dysfunction, inflammation and low plasma albumin, all of which predi... Read More about Clinical validation of near-patient assessment of fluid status in dialysis patients.

Time-dependent markers of comorbidity and prognosis in heart failure patients: transitions across the life course
Thesis
Rushton, C. A. (2016). Time-dependent markers of comorbidity and prognosis in heart failure patients: transitions across the life course

Heart failure (HF) disease carries a poor prognosis despite optimisation of cardiovascular (CVD) treatments. Non-CVD comorbid diseases are common and known to influence the HF clinical course. These comorbidities change in severity over time from new... Read More about Time-dependent markers of comorbidity and prognosis in heart failure patients: transitions across the life course.

Polymyalgia rheumatica in primary care: an exploration of the challenges of diagnosis and management using survey and qualitative methods
Thesis
Helliwell, T. (2016). Polymyalgia rheumatica in primary care: an exploration of the challenges of diagnosis and management using survey and qualitative methods

Background: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older people and is closely related to giant cell arteritis (GCA). Most PMR patients are diagnosed and managed in general practice yet primary... Read More about Polymyalgia rheumatica in primary care: an exploration of the challenges of diagnosis and management using survey and qualitative methods.