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The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry (2014)
Journal Article
Fuller, H. R., Hurtado, M. L., Wishart, T. M., & Gates, M. A. (2014). The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry. Proteome Science, 1-20. https://doi.org/10.1186/1477-5956-12-20

BACKGROUND: Idiopathic Parkinson's disease is marked by degeneration of dopamine neurons projecting from the substantia nigra to the striatum. Although proteins expressed by the target striatum can positively affect the viability and growth of dopami... Read More about The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry.

Development of a behaviour change intervention: a case study on the practical application of theory (2014)
Journal Article
Porcheret, M., Main, C., Croft, P., McKinley, R., Hassell, A., & Dziedzic, K. (2014). Development of a behaviour change intervention: a case study on the practical application of theory. Implementation Science, 9, Article 42. https://doi.org/10.1186/1748-5908-9-42

BACKGROUND: Use of theory in implementation of complex interventions is widely recommended. A complex trial intervention, to enhance self-management support for people with osteoarthritis (OA) in primary care, needed to be implemented in the Managing... Read More about Development of a behaviour change intervention: a case study on the practical application of theory.

Changing policy and practice: making sense of national guidelines for osteoarthritis. (2014)
Journal Article
Dziedzic, & jinks. (2014). Changing policy and practice: making sense of national guidelines for osteoarthritis. Social Science and Medicine, 101 -109. https://doi.org/10.1016/j.socscimed.2014.01.036

Understanding uptake of complex interventions is an increasingly prominent area of research. The interplay of macro (such as changing health policy), meso (re-organisation of professional work) and micro (rationalisation of clinical care) factors upo... Read More about Changing policy and practice: making sense of national guidelines for osteoarthritis..

General practitioners' perspectives on campaigns to promote rapid help-seeking behaviour at the onset of rheumatoid arthritis. (2014)
Journal Article
Mallen. (2014). General practitioners' perspectives on campaigns to promote rapid help-seeking behaviour at the onset of rheumatoid arthritis. Scandinavian Journal of Primary Health Care, 37 - 43. https://doi.org/10.3109/02813432.2014.900239

OBJECTIVE: To explore general practitioners' (GPs') perspectives on public health campaigns to encourage people with the early symptoms of rheumatoid arthritis (RA) to seek medical help rapidly. DESIGN: Nineteen GPs participated in four semi-structur... Read More about General practitioners' perspectives on campaigns to promote rapid help-seeking behaviour at the onset of rheumatoid arthritis..

Defining and mapping the person with osteoarthritis for population studies and public health (2014)
Journal Article
(2014). Defining and mapping the person with osteoarthritis for population studies and public health. Rheumatology, 338 -345. https://doi.org/10.1093/rheumatology/ket346

OBJECTIVE: To determine population-based estimates for the prevalence of the person with OA, predicted to be the single greatest cause of disability in the general population by 2030, in order to inform the planning and commissioning of health, socia... Read More about Defining and mapping the person with osteoarthritis for population studies and public health.

FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators. (2014)
Journal Article
Hunter, S. (2014). FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators. International Journal of Stroke, 240 -245. https://doi.org/10.1111/ijs.12179

RATIONALE: Functional strength training in addition to conventional physical therapy could enhance upper limb recovery early after stroke more than movement performance therapy plus conventional physical therapy. AIMS: To determine (a) the relative c... Read More about FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators..

"Somebody to Say 'Come On We Can Sort This'": A Qualitative Study of Primary Care Consultation Among Older Adults With Symptomatic Foot Osteoarthritis (2013)
Journal Article
Thomas, M., Moore, A., Roddy, E., & Peat, G. (2013). "Somebody to Say 'Come On We Can Sort This'": A Qualitative Study of Primary Care Consultation Among Older Adults With Symptomatic Foot Osteoarthritis. Arthritis Care and Research, 65(12), 2051 - 2055. https://doi.org/10.1002/acr.22073

Objective
To examine the experiences of primary care consultation among older adults with symptomatic foot osteoarthritis (OA).

Methods
Eleven participants (6 women and 5 men) ages 56–80 years who had radiographically confirmed symptomatic foot... Read More about "Somebody to Say 'Come On We Can Sort This'": A Qualitative Study of Primary Care Consultation Among Older Adults With Symptomatic Foot Osteoarthritis.

Designing a placebo device: involving service users in clinical trial design (2013)
Journal Article
Jinks, & Dziedzic. (2013). Designing a placebo device: involving service users in clinical trial design. Health Expectations, e100 - e110. https://doi.org/10.1111/hex.12043

BACKGROUND: Service users are increasingly involved in the design of clinical trials and in product and device development. Service user involvement in placebo development is crucial to a credible and acceptable placebo for clinical trials, but such... Read More about Designing a placebo device: involving service users in clinical trial design.

Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature. (2013)
Journal Article
Mallen. (2013). Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature. Arthritis Care & Research, 1916 - 1926. https://doi.org/10.1002/acr.22097

OBJECTIVE: Understanding the features and patterns of symptoms that characterize the earliest stages of rheumatoid arthritis (RA) is of considerable importance if patients are to be identified and started on treatment early. However, little is known... Read More about Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature..

Effectiveness of musculoskeletal education interventions in people with low literacy levels: a systematic review. (2013)
Journal Article
Protheroe. (2013). Effectiveness of musculoskeletal education interventions in people with low literacy levels: a systematic review. Arthritis Care and Research, 1976 - 1985. https://doi.org/10.1002/acr.22085

OBJECTIVE: To conduct a systematic review to assess the effectiveness of patient education interventions delivered or directed by health professionals for people with musculoskeletal conditions who also have lower levels of literacy. METHODS: Electro... Read More about Effectiveness of musculoskeletal education interventions in people with low literacy levels: a systematic review..

The population prevalence of symptomatic radiographic foot osteoarthritis in community-dwelling older adults: cross-sectional findings from the clinical assessment study of the foot. (2013)
Report
Roddy, E., Thomas, M. J., Marshall, M., Rathod, T., Myers, H., Menz, H. B., Thomas, E., & Peat, G. (2013). The population prevalence of symptomatic radiographic foot osteoarthritis in community-dwelling older adults: cross-sectional findings from the clinical assessment study of the foot. N/A

OBJECTIVES: To estimate the population prevalence of symptomatic radiographic osteoarthritis (OA) affecting the 1st metatarsophalangeal joint (MTPJ), 1st and 2nd cuneometatarsal joints (CMJs), navicular first cuneiform joint (NCJ) and talonavicular j... Read More about The population prevalence of symptomatic radiographic foot osteoarthritis in community-dwelling older adults: cross-sectional findings from the clinical assessment study of the foot..

Improvement in the management of gout is vital and overdue: an audit from a UK primary care medical practice (2013)
Journal Article
Roddy. (2013). Improvement in the management of gout is vital and overdue: an audit from a UK primary care medical practice. BMC Family Practice, 170 - ?. https://doi.org/10.1186/1471-2296-14-170

BACKGROUND: Gout is estimated to affect 1.4% of adults in the UK. Appropriate and timely management is essential to reduce the risk of further flares, complications, and to reduce cardiovascular disease risk. The British Society for Rheumatology and... Read More about Improvement in the management of gout is vital and overdue: an audit from a UK primary care medical practice.

Reliability of Assessing Hand Osteoarthritis on Digital Photographs and Associations With Radiographic and Clinical Findings. (2013)
Journal Article
Marshall, M., Jonsson, H., Helgadottir, G. P., Nicholls, E., Van Der Windt, D., Myers, H., & Dziedzic, K. (2014). Reliability of Assessing Hand Osteoarthritis on Digital Photographs and Associations With Radiographic and Clinical Findings. Arthritis Care & Research, 66(6), 828 - 836. https://doi.org/10.1002/acr.22225

OBJECTIVE: To investigate the reliability and construct validity of an atlas for grading hand osteoarthritis (OA) on photographs in a separate younger community-dwelling population than the development cohort. METHODS: Participants were community-dwe... Read More about Reliability of Assessing Hand Osteoarthritis on Digital Photographs and Associations With Radiographic and Clinical Findings..

Characteristics of acupuncture treatment associated with outcome: an individual patient meta-analysis of 17,922 patients with chronic pain in randomised controlled trials (2013)
Journal Article
(2013). Characteristics of acupuncture treatment associated with outcome: an individual patient meta-analysis of 17,922 patients with chronic pain in randomised controlled trials. PloS one, e77438 -?. https://doi.org/10.1371/journal.pone.0077438

BACKGROUND: Recent evidence shows that acupuncture is effective for chronic pain. However we do not know whether there are characteristics of acupuncture or acupuncturists that are associated with better or worse outcomes. METHODS: An existing datase... Read More about Characteristics of acupuncture treatment associated with outcome: an individual patient meta-analysis of 17,922 patients with chronic pain in randomised controlled trials.

Association of glycation gap with mortality and vascular complications in diabetes (2013)
Journal Article
(2013). Association of glycation gap with mortality and vascular complications in diabetes. Diabetes Care, 3247 -3253. https://doi.org/10.2337/dc12-1040

OBJECTIVE: The "glycation gap" (G-gap), an essentially unproven concept, is an empiric measure of disagreement between HbA1c and fructosamine, the two indirect estimates of glycemic control. Its association with demographic features and key clinical... Read More about Association of glycation gap with mortality and vascular complications in diabetes.

Opioid use among low back pain patients in primary care: Is opioid prescription associated with disability at 6-month follow-up? (2013)
Journal Article
Ashworth, J., Green, D. J., Dunn, K. M., & Jordan, K. P. (2013). Opioid use among low back pain patients in primary care: Is opioid prescription associated with disability at 6-month follow-up?. PAIN, 1038 - 1044. https://doi.org/10.1016/j.pain.2013.03.011

Opioid prescribing for chronic noncancer pain is increasing, but there is limited knowledge about longer-term outcomes of people receiving opioids for conditions such as back pain. This study aimed to explore the relationship between prescribed opioi... Read More about Opioid use among low back pain patients in primary care: Is opioid prescription associated with disability at 6-month follow-up?.

The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months (2013)
Journal Article
Ali, K., Warusevitane, A., Lally, F., Sim, J., Sills, S., Pountain, S., Nevatte, T., Allen, M., & Roffe, C. (2013). The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months. PloS one, 8(6), Article e59274. https://doi.org/10.1371/journal.pone.0059274

INTRODUCTION: Post-stroke hypoxia is common, and may adversely affect outcome. We have recently shown that oxygen supplementation may improve early neurological recovery. Here, we report the six-month outcomes of this pilot study. METHODS: Patients w... Read More about The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months.