Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. (2020)
Journal Article
Guinan, M., Benckendorff, C., Smith, M., & Miller, G. (2020). Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules, 25(9), https://doi.org/10.3390/molecules25092050

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, thes... Read More about Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues..

Calcification Microstructure Reflects Breast Tissue Microenvironment (2019)
Journal Article
Gosling, S., Scott, R., Greenwood, C., Bouzy, P., Nallala, J., D. Lyburn, I., Stone, N., & Rogers, K. (2019). Calcification Microstructure Reflects Breast Tissue Microenvironment. Journal of Mammary Gland Biology and Neoplasia, 333-342. https://doi.org/10.1007/s10911-019-09441-3

Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. Hydroxyapatite microcalcific... Read More about Calcification Microstructure Reflects Breast Tissue Microenvironment.

Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells (2018)
Journal Article
Watkinson. (2018). Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells. Chemical Communications, 9619-9266. https://doi.org/10.1039/c8cc05425h

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We... Read More about Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells.

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain. (2017)
Journal Article
DiCara, D. M., Chirgadze, D. Y., Pope, A. R., Karatt-Vellatt, A., Winter, A., Slavny, P., van den Heuvel, J., Parthiban, K., Holland, J., Packman, L. C., Mavria, G., Hoffmann, J., Birchmeier, W., Gherardi, E., & McCafferty, J. (2017). Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain. Scientific reports, 9000 - ?. https://doi.org/10.1038/s41598-017-09460-2

The growth and motility factor Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its receptor, the product of the MET proto-oncogene, promote invasion and metastasis of tumor cells and have been considered potential targets for cancer therapy. We... Read More about Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain..

Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study (2017)
Journal Article
(2017). Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine, 79-85. https://doi.org/10.1016/j.ebiom.2017.06.005

Background
Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP... Read More about Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study.