miRNAs in bone metastasis (2017)
Journal Article
Cheung, D. G., Buzzetti, M., & Di Leva, G. (2017). miRNAs in bone metastasis. Expert Review of Endocrinology and Metabolism, 12(6), 451-461. https://doi.org/10.1080/17446651.2017.1383893

INTRODUCTION: Bone metastasis is one of the most common forms of metastasis from a number of different primary carcinomas. MicroRNAs (miRNAs) are short, endogenous RNAs that negatively regulate gene expression to control essential pathways, including... Read More about miRNAs in bone metastasis.

Nanotechnologies in Pancreatic Cancer Therapy. (2017)
Journal Article
Manzur, A., Hoskins, C., Oluwasanmi, A., Moss, D., & Curtis, A. (2017). Nanotechnologies in Pancreatic Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics9040039

Pancreatic cancer has been classified as a cancer of unmet need. After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical re... Read More about Nanotechnologies in Pancreatic Cancer Therapy..

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article
(2017). Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. Journal of Controlled Release, 355-364. https://doi.org/10.1016/j.jconrel.2017.09.027

Abstract Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system wa... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer (2017)
Presentation / Conference Contribution
Butcher, J. B., Rutter, A. V., Wootton, A. J., Day, C. R., & Sulé-Suso, J. (2017, September). Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer. Presented at 17th Annual UK Workshop on Computational Intelligence, Cardiff, Wales, UK

Lung cancer is a widespread disease and it is well understood that systematic, non-invasive and early detection of this progressive and life-threatening disorder is of vital importance for patient outcomes. In this work we present a convergence of fa... Read More about Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer.

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain. (2017)
Journal Article
DiCara, D. M., Chirgadze, D. Y., Pope, A. R., Karatt-Vellatt, A., Winter, A., Slavny, P., van den Heuvel, J., Parthiban, K., Holland, J., Packman, L. C., Mavria, G., Hoffmann, J., Birchmeier, W., Gherardi, E., & McCafferty, J. (2017). Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain. Scientific reports, 9000 - ?. https://doi.org/10.1038/s41598-017-09460-2

The growth and motility factor Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and its receptor, the product of the MET proto-oncogene, promote invasion and metastasis of tumor cells and have been considered potential targets for cancer therapy. We... Read More about Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain..

Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells (2017)
Journal Article
Abed, M., Richardson, A., & Abdullah, M. (2017). Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Scientific reports, 8090 -?. https://doi.org/10.1038/s41598-017-08649-9

Only 40% of patients with advanced ovarian cancer survive more than 5 years. We have previously shown that pitavastatin induces regression of ovarian cancer xenografts in mice. To evaluate whether the response of ovarian cancer cells to pitavastatin... Read More about Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells.

Thermally Triggered Theranostics for Pancreatic Cancer Therapy (2017)
Journal Article
Malekigorji, M., Alfahad, M., Kong Thoo Lin, P., Jones, S., Curtis, A., & Hoskins, C. (2017). Thermally Triggered Theranostics for Pancreatic Cancer Therapy. Nanoscale, https://doi.org/10.1039/C7NR02751F

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation re... Read More about Thermally Triggered Theranostics for Pancreatic Cancer Therapy.

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. (2017)
Journal Article
Kwong, J. (2017). A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. Oncogene, 3576 - 3587. https://doi.org/10.1038/onc.2016.509

Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts... Read More about A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR..

Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. (2017)
Journal Article
(2017). Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer, 4971096 - ?. https://doi.org/10.1155/2017/4971096

One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity and specificity for sentinel node assessment. The aim of this study was to assess the impact of OSNA on micrometastases detection rates and use of adjuv... Read More about Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy..

Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study (2017)
Journal Article
(2017). Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine, 79-85. https://doi.org/10.1016/j.ebiom.2017.06.005

Background
Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP... Read More about Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study.

Partial breast radiotherapy after breast conservation: 5 year outcomes from the IMPORT LOW (CRUK/06/003) phase III trial (2017)
Presentation / Conference Contribution
Coles, C., Griffin, C., Kirby, A., Agrawal, R., Alhasso, A., Bhattacharya, I., Brunt, A., Ciurlionis, L., Chan, H., Donovan, E., Emson, M., Harnett, A., Haviland, J., Hopwood, P., Jefford, M., Kaggwa, R., Sawyer, E., Sybdikus, I., Tsang, Y., Wheatley, D., …Bliss, J. (2017, May). Partial breast radiotherapy after breast conservation: 5 year outcomes from the IMPORT LOW (CRUK/06/003) phase III trial. Paper presented at ESTRO 36, Vienna, Austria

Conference abstract. Part of special issue:
ESTRO 36, May 5-9, 2017, Vienna, Austria.

Evaluating variability of contouring using ESTRO guidelines for elective breast cancer radiotherapy (2017)
Presentation / Conference Contribution
Brunt. Evaluating variability of contouring using ESTRO guidelines for elective breast cancer radiotherapy. Presented at ESTRO 36, May 5-9, 2017, Vienna, Austria

Conference abstract. part of Special Issue ESTRO 36, May 5-9, 2017, Vienna, Austria.

The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT (2017)
Journal Article
Solis-Trapala. (2017). The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT. British journal of cancer, 1111-1117. https://doi.org/10.1038/bjc.2017.72

Background:
To examine the impact of multimodal (MMS) and ultrasound (USS) screening on the sexual activity and functioning of 22?966 women in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) RCT.

Methods:
Fallowfield’s Sexual Ac... Read More about The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT.

Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging. (2017)
Journal Article
Baran, P., Pacile, S., Nesterets, Y., Mayo, S., Dullin, C., Dreossi, D., Arfelli, F., Thompson, D., Lockie, D., McCormack, M., Taba, S., Brun, F., Pinamonti, M., Nickson, C., Hall, C., Dimmock, M., Zanconati, F., Cholewa, M., Quiney, H., Brennan, P., …Gureyev, T. (2017). Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging. Physics in Medicine and Biology, 2315 - 2332. https://doi.org/10.1088/1361-6560/aa5d3d

The aim of this study was to optimise the experimental protocol and data analysis for in-vivo breast cancer x-ray imaging. Results are presented of the experiment at the SYRMEP beamline of Elettra Synchrotron using the propagation-based phase-contras... Read More about Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging..

Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics (2017)
Journal Article
(2017). Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics. Seminars in Cancer Biology, 35-41. https://doi.org/10.1016/j.semcancer.2017.01.004

Breast cancer is the leading cause of cancer-related death in women in Europe and North America, and metastasis is the primary cause of fatality in patients with breast cancer. While some breast cancers are quite treatable, the triple-negative breast... Read More about Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics.

Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients (2017)
Journal Article
Mamas. (2017). Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients. American Journal of Cardiology, 284-289. https://doi.org/10.1016/j.amjcard.2016.09.036

Radiotherapy can affect the electronic components of a cardiac implantable electronic device (CIED) resulting in malfunction and/or damage. We sought to assess the incidence, predictors, and clinical impact of CIED dysfunction (CIED-D) after radiothe... Read More about Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients.