Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019 (2023)
Journal Article
Ajabnoor, A. M., Parisi, R., Zghebi, S. S., Ashcroft, D. M., Faivre‐Finn, C., Morris, C., Mamas, M. A., & Kontopantelis, E. (in press). Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019. Cancer, https://doi.org/10.1002/cncr.35152

Background
Anticoagulation of patients with atrial fibrillation (AF) and cancer is challenging because of their high risk for stroke and bleeding. Little is known of the variations of oral anticoagulant (OAC) prescribing in patients with AF with and... Read More about Oral anticoagulant prescribing among patients with cancer and atrial fibrillation in England, 2009–2019.

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article
Dowling, L. M., Roach, P., Magnussen, E. A., Kohler, A., Pillai, S., van Pittius, D. G., Yousef, I., & Sulé-Suso, J. (in press). Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy. PLoS ONE, 18(8), Article e0289824. https://doi.org/10.1371/journal.pone.0289824

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study. (2023)
Journal Article
Oswald, A., Symeonides, S., Wheatley, D., Chan, S., Brunt, A., McAdam, K., Schmid, P., Waters, S., Poole, C., Twelves, C., Perren, T., Bartlett, J., Piper, T., Chisholm, E., Welsh, M., Hill, R., Hopcroft, L., Barrett-Lee, P., & Cameron, D. (2023). Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study. Breast Cancer Research and Treatment, 199, https://doi.org/10.1007/s10549-023-06873-8

PURPOSE: The development of oestrogen resistance is a major challenge in managing hormone-sensitive metastatic breast cancer. Saracatinib (AZD0530), an oral Src kinase inhibitor, prevents oestrogen resistance in animal models and reduces osteoclast a... Read More about Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study..

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article
Kavousi, N., Tonge, D. P., & Mourtada-Maarabouni, M. (2023). New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. International Journal of Biological Macromolecules, 233, Article 123467. https://doi.org/10.1016/j.ijbiomac.2023.123467

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort (2023)
Journal Article
Chufal, K. S., Ahmad, I., Bajpai, R., Miller, A. A., Chowdhary, R. L., Makker, J., Batra, U., Nathany, S., Sharief, M. I., Umesh, P., Sharma, M., Amrith, P., Pahuja, A. K., Sethi, J., Varghese /, A., Antony, V., & Gairola, M. (2023). Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort. British Journal of Radiology, 96(1143), Article ARTN 20220413. https://doi.org/10.1259/bjr.20220413

Objective: To evaluate treatment outcomes in patients from a low-middle income country (LMIC) with esophageal carcinoma who underwent esophagectomy after neoadjuvant chemoradiation (NACRT/S). Methods: Between 2010 and 2020, 254 patients (median follo... Read More about Tri- modality therapy in advanced esophageal carcinoma: long- term results and insights from a developing world, institutional cohort.

Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose. (2023)
Journal Article
Kit Loong Tuan, J., Qi Tan, H., Li Kuan Ong, A., Knight, K., Panettieri, V., Dimmock, M., & Wright, C. (2023). Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose. https://doi.org/10.1016/j.phro.2023.100421

BACKGROUND AND PURPOSE: Significant deviations between bladder dose planned (DP) and dose accumulated (DA) have been reported in patients receiving radiotherapy for prostate cancer. This study aimed to construct multivariate analysis (MVA) models to... Read More about Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose..