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Partial breast radiotherapy after breast conservation: 5 year outcomes from the IMPORT LOW (CRUK/06/003) phase III trial (2017)
Presentation / Conference Contribution
Coles, C., Griffin, C., Kirby, A., Agrawal, R., Alhasso, A., Bhattacharya, I., Brunt, A., Ciurlionis, L., Chan, H., Donovan, E., Emson, M., Harnett, A., Haviland, J., Hopwood, P., Jefford, M., Kaggwa, R., Sawyer, E., Sybdikus, I., Tsang, Y., Wheatley, D., …Bliss, J. (2017, May). Partial breast radiotherapy after breast conservation: 5 year outcomes from the IMPORT LOW (CRUK/06/003) phase III trial. Presented at ESTRO 36, Vienna, Austria

Conference abstract. Part of special issue:
ESTRO 36, May 5-9, 2017, Vienna, Austria.

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. (2017)
Journal Article
Kwong, J. (2017). A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. Oncogene, 3576 - 3587. https://doi.org/10.1038/onc.2016.509

Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts... Read More about A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR..

Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. (2017)
Journal Article
(2017). Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy. International Journal of Breast Cancer, 4971096 - ?. https://doi.org/10.1155/2017/4971096

One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity and specificity for sentinel node assessment. The aim of this study was to assess the impact of OSNA on micrometastases detection rates and use of adjuv... Read More about Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy..

Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study (2017)
Journal Article
(2017). Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine, 79-85. https://doi.org/10.1016/j.ebiom.2017.06.005

Background
Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP... Read More about Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study.

The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT (2017)
Journal Article
Solis-Trapala. (2017). The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT. British journal of cancer, 1111-1117. https://doi.org/10.1038/bjc.2017.72

Background:
To examine the impact of multimodal (MMS) and ultrasound (USS) screening on the sexual activity and functioning of 22?966 women in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) RCT.

Methods:
Fallowfield’s Sexual Ac... Read More about The effect of ovarian cancer screening on sexual activity and functioning: results from the UK collaborative trial of ovarian cancer screening RCT.

Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging. (2017)
Journal Article
Baran, P., Pacile, S., Nesterets, Y., Mayo, S., Dullin, C., Dreossi, D., Arfelli, F., Thompson, D., Lockie, D., McCormack, M., Taba, S., Brun, F., Pinamonti, M., Nickson, C., Hall, C., Dimmock, M., Zanconati, F., Cholewa, M., Quiney, H., Brennan, P., …Gureyev, T. (2017). Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging. Physics in Medicine and Biology, 2315 - 2332. https://doi.org/10.1088/1361-6560/aa5d3d

The aim of this study was to optimise the experimental protocol and data analysis for in-vivo breast cancer x-ray imaging. Results are presented of the experiment at the SYRMEP beamline of Elettra Synchrotron using the propagation-based phase-contras... Read More about Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging..

Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics (2017)
Journal Article
(2017). Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics. Seminars in Cancer Biology, 35-41. https://doi.org/10.1016/j.semcancer.2017.01.004

Breast cancer is the leading cause of cancer-related death in women in Europe and North America, and metastasis is the primary cause of fatality in patients with breast cancer. While some breast cancers are quite treatable, the triple-negative breast... Read More about Na+/H+ exchanger-mediated hydrogen ion extrusion as a carcinogenic signal in triple-negative breast cancer etiopathogenesis and prospects for its inhibition in therapeutics.

Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients (2017)
Journal Article
Mamas. (2017). Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients. American Journal of Cardiology, 284-289. https://doi.org/10.1016/j.amjcard.2016.09.036

Radiotherapy can affect the electronic components of a cardiac implantable electronic device (CIED) resulting in malfunction and/or damage. We sought to assess the incidence, predictors, and clinical impact of CIED dysfunction (CIED-D) after radiothe... Read More about Radiotherapy-induced cardiac implantable electronic device disorders in cancer patients.

Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning (2016)
Journal Article
Siddique, M., Rutter, A., Wehbe, K., Cinque, G., Bellisola, G., & Sule-Suso, J. (2016). Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning. Analyst, 8(142), 1299-1307. https://doi.org/10.1039/c6an01914e

Over the last few years, both synchrotron-based FTIR (S-FTIR) and Raman microspectroscopies have helped to better understand the effects of drugs on cancer cells. However, cancer is a mixture of cells with different sensitivity/resistance to drugs. F... Read More about Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning.

Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia (2016)
Presentation / Conference
Mourtada Maarabouni, M., Hanson, R., Sivanandan, C., & Ladna, A. (2016, November). Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia. Presented at NCRI Cancer Conference, Liverpool

Abstract

Background

The serine/ threonine protein phosphatase 4 (PP4) has been identified to play a role in apoptosis and tumorigenesis. The PP4 holoenzyme consists of PP4 catalytic subunit (PP4c) which interacts with four different regulatory... Read More about Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia.

Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy (2016)
Journal Article
Oluwasanmi, A., Malekigorji, M., Jones, S., Curtis, A., & Hoskins, C. (2016). Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy. RSC advances, https://doi.org/10.1039/c6ra20552f

Theranostics are emerging platforms for rapid cancer diagnosis and therapy. Hybrid iron oxide–gold nanoparticles (HNPs) have shown potential as theranostics due to their ability for imaging using MRI, heating using laser irradiation and carrier abili... Read More about Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy.

Bowel cancer screening and people with intellectual disabilities: working in co-production and establishing principles for good practice initiatives (2016)
Journal Article
(2016). Bowel cancer screening and people with intellectual disabilities: working in co-production and establishing principles for good practice initiatives. Learning Disability Practice, 33-39. https://doi.org/10.7748/ldp.2016.e1766

Bowel cancer is the fourth most common cancer in England, and with one in 20 people developing the condition, it is the second highest cause of cancer deaths. If diagnosed early, treatment can be more effective and bowel cancer screening programmes c... Read More about Bowel cancer screening and people with intellectual disabilities: working in co-production and establishing principles for good practice initiatives.

miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer (2016)
Journal Article
D'Ippolito, E., Plantamura, I., Bongiovanni, L., Casalini, P., Baroni, S., Piovan, C., Orlandi, R., Gualeni, A. V., Gloghini, A., Rossini, A., Cresta, S., Tessari, A., De Braud, F., Di Leva, G., Tripodo, C., & Iorio, M. V. (2016). miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer. Cancer research, 76(18), 5562 - 5572. https://doi.org/10.1158/0008-5472.CAN-16-0140

Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRß has been identified as a ke... Read More about miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer.

KR-33028, a potent inhibitor of the Na(+)/H(+) exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells (2016)
Journal Article
(2016). KR-33028, a potent inhibitor of the Na(+)/H(+) exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells. Biochemical Pharmacology, 31 -39. https://doi.org/10.1016/j.bcp.2016.08.010

Hyper-activation of the Na(+)/H(+) exchanger NHE1 occurs at the onset of oncogenic transformation and plays a critical role in breast cancer carcinogenesis. Dysregulation of NHE1 activity results in intracellular alkalinization and the acidification... Read More about KR-33028, a potent inhibitor of the Na(+)/H(+) exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells.

The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells (2016)
Journal Article
Mohammed, H. N., Pickard, M. R., & Mourtada-Maarabouni, M. (2016). The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. Cellular Signalling, 1389 - 1400. https://doi.org/10.1016/j.cellsig.2016.06.011

Background:
The control of breast cell survival is of critical importance for preventing breast cancer initiation and progression. The activity of many proteins which regulate cell survival is controlled by reversible phosphorylation, so that the re... Read More about The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.