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Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells (2016)
Journal Article
(2016). Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells. Oncotarget, 21091 -21113. https://doi.org/10.18632/oncotarget.8520

In triple-negative breast cancer (TNBC), the high recurrence rate, increased invasion and aggressive metastatic formation dictate patient survival. We previously demonstrated a critical role for the Na+/H+ exchanger isoform 1 (NHE1) in controlling me... Read More about Na+/H+ exchanger NHE1 regulation modulates metastatic potential and epithelial-mesenchymal transition of triple-negative breast cancer cells.

Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells (2016)
Journal Article
Abed, M., Abdullah, M., & Richardson, A. (2016). Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. Journal of Ovarian Research, 25 - ?. https://doi.org/10.1186/s13048-016-0234-y

BACKGROUND: BH3 mimetics are a class of drugs that antagonize the Bcl-2 family of apoptosis inhibitors. We have previously shown that these compounds can potentiate the activity of carboplatin against several ovarian cancer cell lines. However, recen... Read More about Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.

Awareness of Risk Factors for Breast, Lung and Cervical Cancer in a UK Student Population (2015)
Journal Article
Sherman, S., & Lane, E. (2015). Awareness of Risk Factors for Breast, Lung and Cervical Cancer in a UK Student Population. Journal of Cancer Education, 660 -663

The objective of this study is to identify levels of risk awareness for breast, lung and cervical cancer, in a UK student population. A sample of male (N=62) and female (N=58) university students, mean age 21.62 years completed a questionnaire identi... Read More about Awareness of Risk Factors for Breast, Lung and Cervical Cancer in a UK Student Population.

The vacuolar ATPase subunit E controls apoptosis and is down-regulated in breast cancer (2015)
Presentation / Conference
Mohammed, S., & Mourtada-Maarabouni, M. (2015, November). The vacuolar ATPase subunit E controls apoptosis and is down-regulated in breast cancer. Poster presented at 11th NCRI Cancer Conference, Liverpool

Background
Vacuolar H+-ATPase (v-ATPase) is a large multisubunit proton pump that mediates the acidification of many intracellular compartments. Previous studies have strongly implicated v-ATPase in carcinogenesis and tumour progression and indicat... Read More about The vacuolar ATPase subunit E controls apoptosis and is down-regulated in breast cancer.

Awareness and knowledge of HPV and cervical cancer in female students: A survey (with a cautionary note) (2015)
Journal Article
Minshall, C., Coombes, R., Cooper, J., Redman, C., Sherman, S., & Nailer, E. (2015). Awareness and knowledge of HPV and cervical cancer in female students: A survey (with a cautionary note). Journal of Obstetrics and Gynaecology, 76 -80. https://doi.org/10.3109/01443615.2015.1041886

We conducted a survey to explore levels of awareness and knowledge of human papillomavirus (HPV) and cervical cancer in 170 female students and whether mode of data collection (online vs. paper) affected the results. 27% of women named HPV as a cause... Read More about Awareness and knowledge of HPV and cervical cancer in female students: A survey (with a cautionary note).

Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis? (2015)
Journal Article
(2015). Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?. International Journal of Developmental Biology, 367 -377. https://doi.org/10.1387/ijdb.140336lf

Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal express... Read More about Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?.

[5.9] Radio 4 -Womens hour interview (2015)
Digital Artefact
Sherman. (2015). [5.9] Radio 4 -Womens hour interview

Impact REF21 - Interview on Cervical Cancer and smear tests in women over 50.

In Situ Measurement of Magnetization Relaxation of Internalized Nanoparticles in Live Cells. (2015)
Journal Article
Soukup, D., Moise, S., Céspedes, E., Dobson, J., & Telling, N. D. (2015). In Situ Measurement of Magnetization Relaxation of Internalized Nanoparticles in Live Cells. ACS nano, 9(1), 231-240. https://doi.org/10.1021/nn503888j

Magnetization relaxation mechanisms strongly influence how magnetic nanoparticles respond to high-frequency fields in applications such as magnetic hyperthermia. The dominant mechanism depends on the mobility of the particles, which will be affected... Read More about In Situ Measurement of Magnetization Relaxation of Internalized Nanoparticles in Live Cells..

The Na?/H? exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells (2014)
Journal Article
(2014). The Na?/H? exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells. Oncotarget, 1262 - 1275. https://doi.org/10.18632/oncotarget.2860

Dysregulation of Na?/H? exchanger isoform one (NHE1) activity is a hallmark of cells undergoing tumorigenesis and metastasis, the leading cause of patient mortality. The acidic tumor microenvironment is thought to facilitate the development of resist... Read More about The Na?/H? exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells.

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas (2014)
Journal Article
Jain, H., Richardson, A., Meyer-Hermann, M., & Byrne, H. (2014). Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas. PloS one, e81582 - ?. https://doi.org/10.1371/journal.pone.0081582

Platinum drug-resistance in ovarian cancers mediated by anti-apoptotic proteins such as Bcl-xL is a major factor contributing to the chemotherapeutic resistance of recurrent disease. Consequently, concurrent inhibition of Bcl-xL in combination with c... Read More about Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas.

On evaluation of a multiscale-based CT image analysis and visualisation algorithm (2013)
Presentation / Conference Contribution
Lam, K., Collins, D., Sule-Suso, J., Bhana, R., & Moloney, A. (2013, December). On evaluation of a multiscale-based CT image analysis and visualisation algorithm. Presented at International Conference on BioMedical Engineering and Informatics (BMEI)

Development of computed tomography (CT) protocols that minimise radiation dose for specific clinical treatments continues to be a major research focus. Building on the success of an earlier collaborative case study concerning prostate cancer diagnosi... Read More about On evaluation of a multiscale-based CT image analysis and visualisation algorithm.

Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials (2012)
Journal Article
(2012). Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials. British journal of cancer, 1257-1267. https://doi.org/10.1038/bjc.2012.370

Background:
The National Epirubicin Adjuvant Trial (NEAT) and BR9601 trials tested the benefit of epirubicin when added to cyclophosphamide, methotrexate and 5-fluorouracil (E-CMF) compared with standard CMF in adjuvant chemotherapy for women with e... Read More about Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials.

The views of patients and the general public about expensive anti-cancer drugs in the NHS: a questionnaire-based study. (2011)
Journal Article
Solis-Trapala. (2011). The views of patients and the general public about expensive anti-cancer drugs in the NHS: a questionnaire-based study. JRSM Short Reports, 69. https://doi.org/10.1258/shorts.2011.011050

OBJECTIVES: To determine the views of patients and members of the public about who should pay for expensive new cancer drugs not recommended by the National Institute for Health and Clinical Excellence (NICE). DESIGN: A study-specific questionnaire w... Read More about The views of patients and the general public about expensive anti-cancer drugs in the NHS: a questionnaire-based study..

Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer (2009)
Journal Article
Pickard, M. R., Green, A. R., Ellis, I. O., Caldas, C., Hedge, V. L., Mourtada-Maarabouni, M., & Williams, G. T. (2009). Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer. Breast Cancer Research, Article R60. https://doi.org/10.1186/bcr2350

INTRODUCTION: Programmed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to... Read More about Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.

A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma (2007)
Journal Article
(2007). A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma. British journal of cancer, 523 -528. https://doi.org/10.1038/sj.bjc.6603576

Ultraviolet radiation exposure increases basal cell carcinoma (BCC) risk, but may be protective against prostate cancer. We attempted to identify exposure patterns that confer reduced prostate cancer risk without increasing that of BCC. We used a que... Read More about A comparison of sunlight exposure in men with prostate cancer and basal cell carcinoma.