Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary (2022)
Journal Article
Fuller, H., & Storey, E. (2022). Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary. Cells, https://doi.org/10.3390/cells11244065

Mutations in genes encoding proteins associated with the linker of nucleoskel-eton and cytoskeleton (LINC) complex within the nuclear envelope cause dif-ferent diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous... Read More about Genotype-phenotype correlations in human diseases caused by mutations of LINC complex-associated genes: a systematic review and meta-summary.

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. (2022)
Journal Article
Dhillon, K., Aizel, K., Broomhall, T., Secret, E., Goodman, T., Rotherham, M., Telling, N., Siaugue, J., Ménager, C., Fresnais, J., Coppey, M., El Haj, A., & Gates, M. (2022). Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. Journal of the Royal Society. Interface, 19(196), https://doi.org/10.1098/rsif.2022.0576

A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards controlling... Read More about Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients..

Heparin: an established anticoagulant drug with therapeutic potential for COVID-19 (2022)
Thesis
McIntosh, O. G. Heparin: an established anticoagulant drug with therapeutic potential for COVID-19. (Thesis). Keele University. https://keele-repository.worktribe.com/output/424531

The biologically and medically important heparan sulphate and heparin polysaccharides have been previously shown to mediate viral cell entry for enveloped viruses. Furthermore, heparin and its analogues have been shown to have anti-inflammatory and a... Read More about Heparin: an established anticoagulant drug with therapeutic potential for COVID-19.

Phenotypic characterization of regional human meniscus progenitor cells. (2022)
Journal Article
(2022). Phenotypic characterization of regional human meniscus progenitor cells. Frontiers in Bioengineering and Biotechnology, 1003966 - ?. https://doi.org/10.3389/fbioe.2022.1003966

Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues. In... Read More about Phenotypic characterization of regional human meniscus progenitor cells..

Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation (2022)
Journal Article
Mottershead. (2022). Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation. https://doi.org/10.22074/CELLJ.2022.8155

Objective: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is low. This study aimed to improve the quality of in vitro vitrified-warmed maturated oocytes... Read More about Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation.

Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking. (2022)
Journal Article
Reynisson. (2022). Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2022.128909

Tyrosyl-DNA phosphodiesterase 1(TDP1) is a promising target for a new therapy in oncological disease as an adjunct to topoisomerase 1 (TOP1) drugs. In this paper, novel thiazolidin-4-one derivatives with a benzyl and monoterpene substituents were syn... Read More about Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking..

Editorial: C. elegans as an emerging model of pharmacological innovation. (2022)
Journal Article
Turnbull, J. (2022). Editorial: C. elegans as an emerging model of pharmacological innovation. Frontiers in Pharmacology, 1029752 - ?. https://doi.org/10.3389/fphar.2022.1029752

3D in-vitro cultures of human bone marrow and Wharton's jelly derived mesenchymal stromal cells show high chondrogenic potential. (2022)
Journal Article
Dale. (2022). 3D in-vitro cultures of human bone marrow and Wharton's jelly derived mesenchymal stromal cells show high chondrogenic potential. Frontiers in Bioengineering and Biotechnology, -. https://doi.org/10.3389/fbioe.2022.986310

In this study, chondrogenic potentials of 3D high-density cultures of Bone Marrow (BM) and Wharton's Jelly (WJ)-derived mesenchymal stromal cells (MSCs) was investigated by chondrogenesis- and cytokine-related gene expression over a 16-day culture pe... Read More about 3D in-vitro cultures of human bone marrow and Wharton's jelly derived mesenchymal stromal cells show high chondrogenic potential..

Exercise Based Cardiac Rehabilitation: Is a Little Encouragement Enough? (2022)
Journal Article
Moore, C., Tsakirides, C., Swainson, M., Buckley, J., & Ispoglou, T. (2022). Exercise Based Cardiac Rehabilitation: Is a Little Encouragement Enough?. Journal of Cardiopulmonary Rehabilitation and Prevention, 42(6), E97-E98. https://doi.org/10.1097/HCR.0000000000000736

New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model (2022)
Journal Article
Dragomanova, S., Lazarova, M., Munkuev, A., Suslov, E., Volcho, K., Salakhutdinov, N., Bibi, A., Reynisson, J., Tzvetanova, E., Alexandrova, A., Georgieva, A., Uzunova, D., Stefanova, M., Kalfin, R., & Tancheva, L. (2022). New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model. Molecules, 27(17), Article 5456. https://doi.org/10.3390/molecules27175456

Alzheimer’s disease (AD) is a neurodegenerative disease associated with memory impairment and other central nervous system (CNS) symptoms. Two myrtenal–adamantane conjugates (MACs) showed excellent CNS potential against Alzheimer’s models. Adamantane... Read More about New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model.

Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial (2022)
Journal Article
Beard, D. J., Davies, L., Cook, J. A., Stokes, J., Leal, J., Fletcher, H., Abram, S., Chegwin, K., Greshon, A., Jackson, W., Bottomley, N., Dodd, M., Bourke, H., Shirkey, B. A., Paez, A., Lamb, S. E., Barker, K., Phillips, M., Brown, M., Lythe, V., …Mohammed, A. (2022). Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial. The Lancet, 400, 605 - 615. https://doi.org/10.1016/S0140-6736%2822%2901424-6

Background
Anterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients w... Read More about Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial.

Remote magnetic actuation of cell signalling for tissue engineering (2022)
Journal Article
Rotherham, M., Nahar, T., Broomhall, T., Telling, N., & El Haj, A. (2022). Remote magnetic actuation of cell signalling for tissue engineering. Current Opinion in Biomedical Engineering, 24, Article 100410. https://doi.org/10.1016/j.cobme.2022.100410

Magnetic nanoparticles (MNP) are extremely versatile tools in bioengineering and medicine with diverse uses ranging from magnetic resonance contrast agents to drug delivery vehicles. Recently, MNP have been adapted to target and regulate cell signall... Read More about Remote magnetic actuation of cell signalling for tissue engineering.

Describing the impact of community pharmacy organisation type on emergency hormonal contraception services in England (2022)
Journal Article
Thayer, N., White, S., & Frisher, M. (2022). Describing the impact of community pharmacy organisation type on emergency hormonal contraception services in England. International Journal of Pharmacy Practice, 30(6), 514–519. https://doi.org/10.1093/ijpp/riac067

OBJECTIVES: In England, non-dispensing pharmacy services are commissioned either nationally or locally. For the national service Medicines Use Reviews (MURs), large multiple/chain pharmacies provide more consultations than independents. This study ai... Read More about Describing the impact of community pharmacy organisation type on emergency hormonal contraception services in England.

The creation of an online learning resource to support the implementation of the nice shared decision making guideline (2022)
Journal Article
Jacklin, Thompson, & Maddock. (2022). The creation of an online learning resource to support the implementation of the nice shared decision making guideline. Pharmacoepidemiology and Drug Safety, 7 - 7. https://doi.org/10.1002/pds.5499

Background: Shared decision making (SDM) is a joint process in which a healthcare professional works together with a person to reach a decision about care1; this can help ensure care is personalised to each individual. Research shows that SDM is not... Read More about The creation of an online learning resource to support the implementation of the nice shared decision making guideline.

Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine (2022)
Journal Article
Dale. (2022). Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine. Tissue engineering. Part A, 249 - 250. https://doi.org/10.1089/ten.tea.2022.29030.abstracts

*Purpose/Objectives: Prolonged alveolar air leaks as post-surgical complications to routine lung resections and biopsies are a significant cause for patient morbidity. Extended duration of chest tube drainage and emergency revision surgeries are the... Read More about Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine.

Dose-volume analysis of planned versus accumulated dose as a predictor for late gastrointestinal toxicity in men receiving radiotherapy for high-risk prostate cancer. (2022)
Journal Article
Ong, A., Knight, K., Panettieri, V., Dimmock, M., Tuan, J., Tan, H., & Wright, C. (2022). Dose-volume analysis of planned versus accumulated dose as a predictor for late gastrointestinal toxicity in men receiving radiotherapy for high-risk prostate cancer. https://doi.org/10.1016/j.phro.2022.07.001

Background and purpose: Significant dose deviations have been reported between planned (DP) and accumulated (DA) dose in prostate radiotherapy. This study aimed to develop multivariate analysis (MVA) models associating Grade 1 and 2 gastrointestinal... Read More about Dose-volume analysis of planned versus accumulated dose as a predictor for late gastrointestinal toxicity in men receiving radiotherapy for high-risk prostate cancer..

Exploring community pharmacists' use of health literacy interventions in their everyday practice. (2022)
Journal Article
White, S., & Cork, T. (2022). Exploring community pharmacists' use of health literacy interventions in their everyday practice. Research in Social and Administrative Pharmacy, 18(11), 3948-3952. https://doi.org/10.1016/j.sapharm.2022.06.007

BACKGROUND: Limited health literacy often results in people inadequately understanding medicines-related information and subsequently not taking medicines as prescribed. Using health literacy interventions is important for community pharmacists, as t... Read More about Exploring community pharmacists' use of health literacy interventions in their everyday practice..

Educational supervision, assessment and feedback for pharmacists (2022)
Journal Article
O'Byrne, R., & Warren, S. (2022). Educational supervision, assessment and feedback for pharmacists. Pharmaceutical Journal, https://doi.org/10.1211/pj.2022.1.148078

Workplace learning has formed part of preregistration training (now foundation training) for many years, and supervision of this is becoming more embedded into pharmacy education and development — both at foundation and advanced level. Effective supe... Read More about Educational supervision, assessment and feedback for pharmacists.

A pilot study of a single intermittent arm cycling exercise programme on people affected by Facioscapulohumeral dystrophy (FSHD). (2022)
Journal Article
(2022). A pilot study of a single intermittent arm cycling exercise programme on people affected by Facioscapulohumeral dystrophy (FSHD). PloS one, e0268990 - ?. https://doi.org/10.1371/journal.pone.0268990

For patients affected by Facioscapulohumeral dystrophy (FSHD), alternate methods for increasing physical activity engagement that may benefit shoulder function and wider health are needed. Arm cycling has been proposed as a potential method for achie... Read More about A pilot study of a single intermittent arm cycling exercise programme on people affected by Facioscapulohumeral dystrophy (FSHD)..

Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice (2022)
Journal Article
Allinson, M., Black, P., & White, S. (2022). Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice. American journal of pharmaceutical education, 86(5), Article 8643. https://doi.org/10.5688/ajpe8643

Objective. For many UK pharmacy students there are minimal opportunities to learn, or be exposed to, different ways of dealing with ethical and professional dilemmas in real life practice during undergraduate education. This study aimed to explore th... Read More about Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice.