Gait rehabilitation for foot and ankle impairments in early rheumatoid arthritis: a feasibility study of a new gait rehabilitation programme (GREAT Strides) (2022)
Journal Article
Hendry, G. J., Bearne, L., Foster, N. E., Godfrey, E., Hider, S., Jolly, L., Mason, H., McConnachie, A., McInnes, I. B., Patience, A., Sackley, C., Sekhon, M., Stanley, B., van der Leeden, M., Williams, A. E., Woodburn, J., & Steultjens, M. P. M. (2022). Gait rehabilitation for foot and ankle impairments in early rheumatoid arthritis: a feasibility study of a new gait rehabilitation programme (GREAT Strides). Pilot and Feasibility Studies, 8(1), Article ARTN 115. https://doi.org/10.1186/s40814-022-01061-9

Background: Foot impairments in early rheumatoid arthritis are common and lead to progressive deterioration of lower limb function. A gait rehabilitation programme underpinned by psychological techniques to improve adherence, may preserve gait and lo... Read More about Gait rehabilitation for foot and ankle impairments in early rheumatoid arthritis: a feasibility study of a new gait rehabilitation programme (GREAT Strides).

Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells (2022)
Journal Article
Dogan, F., Aljumaily, R. M. K., Kitchen, M., & Forsyth, N. R. (2022). Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells. International Journal of Molecular Sciences, 23(10), Article 5854. https://doi.org/10.3390/ijms23105854

Pluripotent stem cells (PSC) possess unlimited proliferation, self-renewal, and a differentiation capacity spanning all germ layers. Appropriate culture conditions are important for the maintenance of self-renewal, pluripotency, proliferation, differ... Read More about Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells.

Perceptual Disorders After Stroke: A Scoping Review of Interventions (2022)
Journal Article
Hunter. (2022). Perceptual Disorders After Stroke: A Scoping Review of Interventions. Stroke, 1772 - 1787. https://doi.org/10.1161/STROKEAHA.121.035671

Perceptual disorders relating to hearing, smell, somatosensation, taste, touch, and vision commonly impair stroke survivors' ability to interpret sensory information, impacting on their ability to interact with the world. We aimed to identify and sum... Read More about Perceptual Disorders After Stroke: A Scoping Review of Interventions.

"Sports and Exercise Medicine Physician?". (2022)
Journal Article
Heron, N., & McLarnon, M. (2022). "Sports and Exercise Medicine Physician?". The Ulster Medical Journal, 111 - 114

In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. (2022)
Journal Article
Kaur Sandhu, A., Yang, Y., & Li, W.-W. (2022). In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis. ACS Biomaterials Science and Engineering, 8(5), 1749-1762. https://doi.org/10.1021/acsbiomaterials.1c01307

Biomaterial-associated infection is difficult to detect and brings consequences that can lead to morbidity and mortality. Bacteria can adhere to the implant surface, grow, and form biofilms. Antimicrobial peptides (AMPs) can target and kill bacterial... Read More about In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants-Systematic Review and Meta-Analysis..

The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial (2022)
Journal Article
Burton, C., Rathod-Mistry, T., Blackburn, S., Blagojevic-Bucknall, M., Bucknall, M., Chesterton, L., Davenport, G., Dziedzic, K., Higginbottom, A., Jowett, S., Myers, H., Oppong, R., van der Windt, D., Hay, E., & Roddy, E. (2023). The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial. Rheumatology, 62(2), 546–554. https://doi.org/10.1093/rheumatology/keac219

Objectives
This follow-up study of the INSTinCTS (INjection vs SplinTing in Carpal Tunnel Syndrome) trial compared the effects of corticosteroid injection (CSI) and night splinting (NS) for the initial management of mild-to-moderate carpal tunnel sy... Read More about The effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome: 24-month follow-up of a randomized trial.

SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS (2022)
Journal Article
Dale. (2022). SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS. Tissue engineering. Part A, S451 - S452

Chronic Obstructive Pulmonary Disease (COPD) presents a significant, incurable, worldwide health burden, identifying it as a prospective regenerative medicine target. Sourcing cells for lung therapies is challenging; progress has been made in culturi... Read More about SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS.

Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture (2022)
Journal Article
Chen, R., Ahmed, M. A., & Forsyth, N. R. (2022). Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture. Biomolecules, 12(4), 541. https://doi.org/10.3390/biom12040541

Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this study is t... Read More about Dimethyloxalylglycine (DMOG), a Hypoxia Mimetic Agent, Does Not Replicate a Rat Pheochromocytoma (PC12) Cell Biological Response to Reduced Oxygen Culture.

A psychological intervention by community pharmacies to prevent depression in adults with subthreshold depression and long-term conditions: the CHEMIST pilot RCT (2022)
Journal Article
Littlewood, E., Chew-Graham, C. A., Coleman, E., Gascoyne, S., Sloan, C., Ali, S., Badenhorst, J., Bailey, D., Crosland, S., Kitchen, C. E., McMillan, D., Pearson, C., Todd, A., Whittlesea, C., Bambra, C., Hewitt, C., Jones, C., Keding, A., Newbronner, E., Paterson, A., …Ekers, D. (2022). A psychological intervention by community pharmacies to prevent depression in adults with subthreshold depression and long-term conditions: the CHEMIST pilot RCT. Public Health Research, 10(5), 1-160. https://doi.org/10.3310/ekze0617

Background Depression is common in people with long-term health conditions, and this combination can lead to worsened health outcomes and increased health-care costs. Subthreshold depression, a risk factor for major depression, is prevalent in this p... Read More about A psychological intervention by community pharmacies to prevent depression in adults with subthreshold depression and long-term conditions: the CHEMIST pilot RCT.

A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy (2022)
Thesis
Hoolachan, J. M. A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/422678

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder (NMD) caused by depleted survival of motor neuron (SMN) levels and characterised by neuronal degeneration and progressive muscle atrophy. Although three approved SMN-depen... Read More about A transcriptomic-based drug repositioning approach for the identification of novel muscle-specific therapies for spinal muscular atrophy.

Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies (2022)
Journal Article
Sim, J., Whelan, G., Smith, B., Moffatt, M., & Littlewood, C. (2022). Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies. Clinical Orthopaedics and Related Research, 480(6), 1061-1074. https://doi.org/10.1097/CORR.0000000000002145

Background
Corticosteroid injection is a very common treatment for individuals experiencing musculoskeletal pain, and it is part of the management of numerous orthopaedic conditions. However, there is concern about offering corticosteroid injections... Read More about Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., Sulé-Suso, J., Forsyth, N., & Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

<jats:p>Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improv... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses (2022)
Journal Article
Bastounis, A., Langley, T., Davis, S., Paskins, Z., Gittoes, N., Leonardi‐Bee, J., & Sahota, O. (2022). Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses. JBMR Plus, 6(5), S270 - S270. https://doi.org/10.1002/jbm4.10620

Bisphosphonates have been found to be effective in preventing fragility fractures. However, their comparative effectiveness in populations at risk has yet to be defined. In light of recent clinical trials, we aimed to compare four bisphosphonates (al... Read More about Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses.

Identification of foods that affect the anti-cancer activity of pitavastatin in cells (2022)
Journal Article
Jawad, M., Ibrahim, S., Kumar, M., Burgert, C., Li, W., & Richardson, A. (2022). Identification of foods that affect the anti-cancer activity of pitavastatin in cells. Oncology Letters, https://doi.org/10.3892/ol.2022.13193

Statins inhibit the synthesis of mevalonate, a precursor isoprenoid molecule to geranylgeraniol that is necessary for the post-translational modification of several small GTPase oncogenes. Despite numerous preclinical studies suggesting that statins... Read More about Identification of foods that affect the anti-cancer activity of pitavastatin in cells.

Comparing medication adherence in patients receiving bisphosphonates for preventing fragility fractures: a comprehensive systematic review and network meta-analysis. (2022)
Journal Article
Paskins. (2022). Comparing medication adherence in patients receiving bisphosphonates for preventing fragility fractures: a comprehensive systematic review and network meta-analysis. Osteoporosis International, https://doi.org/10.1007/s00198-022-06350-w

BACKGROUND: Bisphosphonates are effective in preventing fragility fractures; however, high rates of adherence are needed to preserve clinical benefits. OBJECTIVE: To investigate persistence and compliance to oral and intravenous bisphosphonates (alen... Read More about Comparing medication adherence in patients receiving bisphosphonates for preventing fragility fractures: a comprehensive systematic review and network meta-analysis..

N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties (2022)
Journal Article
Al-Riyahee, A. A. A., Horton, P. N., Coles, S. J., Berry, C., Horrocks, P. D., Pope, S. J. A., & Amoroso, A. J. (2022). N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties. Dalton Transactions, 51(9), 3531-3545. https://doi.org/10.1039/d1dt04091j

The synthesis of six N,N'-substituted thiourea ligands (L1a-L3b) was achieved in two steps. A corresponding extensive series of Cu(I), Cu(II), Ni(II) and Zn(II) complexes (1-24) with varying formulations were synthesised from these ligands by the rea... Read More about N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties.

Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. (2022)
Journal Article
Cosgrove, S. C., & Miller, G. J. (2022). Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. Expert Opinion on Drug Discovery, 17(4), 355-364. https://doi.org/10.1080/17460441.2022.2039620

INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery over the last 60 years. Traditionally accessed using chemical synthesis... Read More about Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues..

Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats (2022)
Journal Article
Okokon, J. E., Davies, K., John, L., Iwara, K., Li, W.-W., & Thomas, P. S. (2022). Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats. Phytomedicine Plus, https://doi.org/10.1016/j.phyplu.2021.100182

Background
Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a grass used ethnomedically by herbalists in Nigeria for the treatment of diabetes was evaluated for antidiabetic, hypolipidemic and pancreas protective potentials in rats.

Methods
So... Read More about Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats.

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile. (2022)
Journal Article
Reynisson. (2022). Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile. Journal of Medicinal Chemistry, 2238 - 2261. https://doi.org/10.1021/acs.jmedchem.1c01740

A series of latonduine and indoloquinoline derivatives HL1-HL8 and their copper(II) complexes (1-8) were synthesized and comprehensively characterized. The structures of five compounds (HL6, [CuCl(L1)(DMF)]·DMF, [CuCl(L2)(CH3OH)], [CuCl(L3)]·0.5H2O,... Read More about Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile..

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. (2022)
Journal Article
Reynisson. (2022). Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. Molecules, 1-14. https://doi.org/10.3390/molecules27030880

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in... Read More about Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action..