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Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate (2024)
Thesis
Logan, S. J. Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate. (Thesis). Keele University. https://keele-repository.worktribe.com/output/956315

Background
Methotrexate is recommended as initial disease modifying anti-rheumatic drug (DMARD) therapy to treat Rheumatoid Arthritis (RA). Rheumatology nurses provide information in DMARD counselling consultations to support people to take treatme... Read More about Exploring the expectations, needs and concerns of people with rheumatoid arthritis commencing Methotrexate.

The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope (2024)
Journal Article
Mercer, L., Abhishek, A., Kavirayani, A., Ahmed, A., Davidson, A., Foulkes, A., Jones, C., Nash, C., Rose-Parfitt, E., Dhillon, E., Zabate, G., Twohig, H., De Vere, H., Scott, J., Reynolds, J., Holmes, J., Hartley, K., Warrier, K., Nowak, K., Parsons, K., …Galloway, J. (in press). The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(3), Article rkae077. https://doi.org/10.1093/rap/rkae077

Lay Summary: What does this mean for patients? A revised guideline, produced by the British Society for Rheumatology (BSR), will provide up-to-date information about the safe prescribing and monitoring of the effects of non-biologic (or conventional... Read More about The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope.

Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma (2024)
Thesis
Franklin, L. H. K. Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775420

Background: In 2020, the NHS developed its carbon net zero goals and highlighted metered dose inhalers (MDIs) as a focal point for change. MDIs are commonly prescribed for asthma in primary care and contain potent greenhouse gases, accounting for 3%... Read More about Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma.

The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study (2022)
Journal Article
Simons, G., Ismail, N., Sandhu, K., Mallen, C. D., Stack, R. J., Pontefract, S., Raza, K., & Falahee, M. (in press). The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study. BMC Rheumatology, 6, Article 50. https://doi.org/10.1186/s41927-022-00280-0

<h4>Background: </h4> Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinical outcomes. Howeve... Read More about The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study.

Educational supervision, assessment and feedback for pharmacists (2022)
Journal Article
O'Byrne, R., & Warren, S. (2022). Educational supervision, assessment and feedback for pharmacists. Pharmaceutical Journal, https://doi.org/10.1211/pj.2022.1.148078

Workplace learning has formed part of preregistration training (now foundation training) for many years, and supervision of this is becoming more embedded into pharmacy education and development — both at foundation and advanced level. Effective supe... Read More about Educational supervision, assessment and feedback for pharmacists.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., Forsyth, N. R., Kehoe, O., & Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine (2021)
Journal Article
Harper. (2022). Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine. Cell Calcium, 101, 102522 - 102522. https://doi.org/10.1016/j.ceca.2021.102522

Human platelets regulate agonist-evoked Ca2+ signalling through Ca2+ release from and sequestration into acidic organelles. Previous studies have pharmacologically characterised the presence of a Ca2+-H+ exchanger in these organelles. This exchanger... Read More about Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine.

Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters (2021)
Journal Article
Perera-Solis, D., Zholobenko, V., Whiting, A., & Greenwell, H. (2021). Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters. RSC advances, 11(56), 35575 - 35584. https://doi.org/10.1039/D1RA06871G

Ketonic decarboxylation has gained significant attention in recent years as a pathway to reduce the oxygen content within biomass-derived oils, and to produce sustainable ketones. The reaction is base catalysed, with MgO an economic, accessible and h... Read More about Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. (2021)
Journal Article
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Davies, J. A., Pia Abbracchio, M., Alexander, W., Al-hosaini, K., Bäck, M., Barnes, N. M., Bathgate, R., Beaulieu, J.-M., …Ye, R. D. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. British Journal of Pharmacology, 178(S1), S27 - S156. https://doi.org/10.1111/bph.15538

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select... Read More about THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors..

Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy (2021)
Journal Article
Bowerman. (2021). Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy. JCI insight, 1-24. https://doi.org/10.1172/jci.insight.149446

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. We aimed to identify novel treatments to alleviate muscle pathology... Read More about Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy.

Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. (2021)
Journal Article
Farooq, S. (2021). Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. Chronic Respiratory Disease, -. https://doi.org/10.1177/14799731211003937

We aimed to review the literature on interventions for treating Common Mental Disorders (CMD) in people with Tuberculosis (TB). We followed PRISMA guidelines and the protocol was registered at PROSPERO. The electronic databases (PsycInfo, CINAHL, Med... Read More about Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review..

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Mallen. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, https://doi.org/10.1093/rheumatology/keab254

OBJECTIVES: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study (2021)
Journal Article
Mamas, & Mallen. (2021). ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keab234

OBJECTIVES: To examine the association between ß-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. Participants aged =40?y... Read More about ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.

The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models (2021)
Journal Article
Njoroge, W., Hernández Hernández, A. C., Idris Musa, F., Butler, R., Harper, A. G. S., & Yang, Y. (2021). The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models. Pharmaceutics, 13(3), Article 340. https://doi.org/10.3390/pharmaceutics13030340

Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo... Read More about The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models.

Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles (2020)
Journal Article
Kehoe, O., Hyland, M., Mennan, C., Wilson, E., & Clayton, A. (2020). Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles. Cells, https://doi.org/10.3390/cells9030726

Umbilical cord mesenchymal stromal cells (UCMSCs) have shown an ability to modulate the immune system through the secretion of paracrine mediators, such as extracellular vesicles (EVs). However, the culture conditions that UCMSCs are grown in can alt... Read More about Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles.

Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview (2020)
Journal Article
Farooq. (2020). Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview. Indian Journal of Psychological Medicine, 4-10. https://doi.org/10.4103/IJPSYM.IJPSYM_379_19

Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach the therapeutic range (350 ng/ml). Thus, serum clozapine concentration-to-dos... Read More about Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview.

Development and validation of a multivariable risk prediction model for serious infection in patients with psoriasis receiving systemic therapy (2019)
Journal Article
Yiu, Z., Sorbe, C., Lunt, M., Rustenbach, S., Kühl, L., Augustin, M., Mason, K., Ashcroft, D., Griffiths, C., Warren, R., BADBIR Study Group, T., Ormerod, A. D., Barker, J. N., Evans, I., McElhone, K., Smith, C. H., Reynolds, N. J., Murphy, R., Benham, M., David Burden, A., …Owen, C. M. (2019). Development and validation of a multivariable risk prediction model for serious infection in patients with psoriasis receiving systemic therapy. British Journal of Dermatology, 180(4), 894 -901. https://doi.org/10.1111/bjd.17421

BACKGROUND: Patients with psoriasis are often concerned about the risk of serious infection associated with systemic psoriasis treatments. OBJECTIVES: To develop and externally validate a prediction model for serious infection in patients with psoria... Read More about Development and validation of a multivariable risk prediction model for serious infection in patients with psoriasis receiving systemic therapy.

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..