Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques (2023)
Thesis
Xie, B. (2023). Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674529

Non-degradable and biodegradable implants inevitably generate debris or degradation products in the body, and these induce acute and chronic inflammation. Polyglycolic acid (PGA) is a simple linear aliphatic polyester with a wide set of medical appli... Read More about Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques.

FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice? (2023)
Thesis
Dowling, L. M. M. (2023). FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice?. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674513

Cancer incidence rates are increasing world-wide including in the UK. An increase in cancer cases puts further pressure on pathology departments that are often already struggling to meet targets to diagnose cancers in a timely manner. Delays in diagn... Read More about FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice?.

Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy (2023)
Thesis
Storey, E. C. (2023). Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674333

LMNA-related congenital muscular dystrophy (L-CMD) is a rare disorder predominantly causing muscle weakness and wasting, over time, leading to development of dysphagia and life-threating respiratory insufficiency, and sometimes cardiac arrhythmias. T... Read More about Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy.

The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study (2023)
Thesis
Ballantyne, S. J. (2023). The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study. (Thesis). Keele University

Introduction
Globally, Chronic Obstructive Pulmonary Disease (COPD) is one of the most important non-communicable diseases with a progressive downhill course.1 Guidelines recommend regular review of patients with COPD.2 In the UK traditionally, ann... Read More about The impact on patients of pharmacist-conducted domiciliary COPD annual reviews: a qualitative study.

Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites (2023)
Journal Article
Li, C., Barroeta, A. B., Wong, S. S., Kim, H. J., Pathak, M., Dreveny, I., …Emsley, J. (2023). Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites. Journal of Thrombosis and Haemostasis, 21(9), 2378-2389. https://doi.org/10.1016/j.jtha.2023.03.042

Background
High–molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK). HK is both a substrate and a cofactor for activated plasma kallikrein, and the principal exosite interactions occur between PK N-termi... Read More about Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites.